Component
Intestinal epithelial lycopene uptake
Intestinal epithelial lycopene uptake. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Caco-2 uptake of cis lycopene exceeded all-trans uptake after simulated gac-meal digestion.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/lycopene-research/18287353.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "55379407d287c9a3c0057c1b7be3834f11e0349aed2821085aa0ef0e1a587ac1", "start_char": 0, "end_char": 1542, "text_sha256": "55379407d287c9a3c0057c1b7be3834f11e0349aed2821085aa0ef0e1a587ac1"}
- experimental_model
- Simulated digestion followed by Caco-2 uptake
- exposure
- Gac aril or oil cooked with rice; isomer-specific measurements
- limitations
- Food matrix and cell model; not a human fractional-absorption comparison.
- nutrient_topic
- Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
- organism
- Cell-free digestion and human Caco-2 cells
- plain_language
- Better delivery to cultured intestinal cells is not automatically better whole-body absorption.
- primary_references
- [lycopene-p18287353] In vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all-trans lycopene. (2008). https://pubmed.ncbi.nlm.nih.gov/18287353/ DOI: 10.1093/jn/138.3.482
- tissue_or_cell_type
- Cooked gac meals; mixed micelles and enterocyte model
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 156–167
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Simulated digestion followed by Caco-2 uptake · source_derived_draft · unverified_draft
### lycopene-cis-caco Caco-2 uptake of cis lycopene exceeded all-trans uptake after simulated gac-meal digestion. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: Better delivery to cultured intestinal cells is not automatically better whole-body absorption. organism: Cell-free digestion and human Caco-2 cells tissue_or_cell_type: Cooked gac meals; mixed micelles and enterocyte model experimental_model: Simulated digestion followed by Caco-2 uptake limitations: Food matrix and cell model; not a human fractional-absorption comparison. exposure: Gac aril or oil cooked with rice; isomer-specific measurements evidence_span: {"source_cache": "artifacts/lycopene-research/18287353.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "55379407d287c9a3c0057c1b7be3834f11e0349aed2821085aa0ef0e1a587ac1", "start_char": 0, "end_char": 1542, "text_sha256": "55379407d287c9a3c0057c1b7be3834f11e0349aed2821085aa0ef0e1a587ac1"} [lycopene-p18287353] In vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all-trans lycopene. (2008). https://pubmed.ncbi.nlm.nih.gov/18287353/ DOI: 10.1093/jn/138.3.482
Complete structured claim and evidenceNPC1L1 antibody and ezetimibe did not significantly reduce all-E or 5Z lycopene uptake in Caco-2 cells.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/lycopene-research/18641187.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7c71fd4fd3be9d14176bceb3c2104143269a788587feec232350a6f1c5913e3d", "start_char": 0, "end_char": 1557, "text_sha256": "7c71fd4fd3be9d14176bceb3c2104143269a788587feec232350a6f1c5913e3d"}
- experimental_model
- Transporter inhibition in Caco-2 cells; intestinal SR-BI transgenic mice
- exposure
- All-E and 5Z lycopene; mice received 0.25 g/kg diet for one month
- limitations
- Partial uptake inhibition is not proof of a sole transporter. Ezetimibe result is a cell assay, not a clinical drug-interaction trial.
- nutrient_topic
- Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
- organism
- Human Caco-2 cells
- plain_language
- A transporter used by other lipids was not necessary in this particular assay.
- primary_references
- [lycopene-p18641187] Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1. (2008). https://pubmed.ncbi.nlm.nih.gov/18641187/ DOI: 10.1093/jn/138.8.1432
- tissue_or_cell_type
- Intestinal epithelium and plasma
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 117–128
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter inhibition in Caco-2 cells; intestinal SR-BI transgenic mice · source_derived_draft · unverified_draft
### lycopene-npc1l1-null NPC1L1 antibody and ezetimibe did not significantly reduce all-E or 5Z lycopene uptake in Caco-2 cells. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: A transporter used by other lipids was not necessary in this particular assay. organism: Human Caco-2 cells tissue_or_cell_type: Intestinal epithelium and plasma experimental_model: Transporter inhibition in Caco-2 cells; intestinal SR-BI transgenic mice limitations: Partial uptake inhibition is not proof of a sole transporter. Ezetimibe result is a cell assay, not a clinical drug-interaction trial. exposure: All-E and 5Z lycopene; mice received 0.25 g/kg diet for one month evidence_span: {"source_cache": "artifacts/lycopene-research/18641187.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7c71fd4fd3be9d14176bceb3c2104143269a788587feec232350a6f1c5913e3d", "start_char": 0, "end_char": 1557, "text_sha256": "7c71fd4fd3be9d14176bceb3c2104143269a788587feec232350a6f1c5913e3d"} [lycopene-p18641187] Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1. (2008). https://pubmed.ncbi.nlm.nih.gov/18641187/ DOI: 10.1093/jn/138.8.1432
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.