Component

Wound healing

Wound healing. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Local transfer of stable HIF-1alpha-expressing adenovirus into experimental wounds in db/db mice had an additive effect on the improvements produced by hyperbaric oxygen.

    HIF-1 alpha → Wound healing source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/hbot-research/25532619.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bb139ca47291f581e4d45523657f9f244734ce42a3e44c5e460671e58946a3ac", "start_char": 0, "end_char": 1943, "text_sha256": "bb139ca47291f581e4d45523657f9f244734ce42a3e44c5e460671e58946a3ac"}
    experimental_model
    Human dermal fibroblasts, SKRC7 cells, HIF-1alpha knockout mouse embryonic fibroblasts, and db/db mice
    exposure
    Hyperbaric oxygen in vitro and in vivo, with adenoviral stable HIF-1alpha delivery
    limitations
    The knockout arm carries the causal claim. The authors describe the stabilisation as non-canonical, so the route from oxygen to HIF stability here is not the classical hydroxylase route.
    nutrient_topic
    Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
    organism
    Mouse
    plain_language
    Adding more of the sensor on top of the treatment helped further.
    primary_references
    [hbot-p25532619] Hyperbaric oxygen therapy activates hypoxia-inducible factor 1 (HIF-1), which contributes to improved wound healing in diabetic mice. (2015). https://pubmed.ncbi.nlm.nih.gov/25532619/ DOI: 10.1111/wrr.12253
    tissue_or_cell_type
    Dermal fibroblasts and diabetic wounds

    Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 647–658

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human dermal fibroblasts, SKRC7 cells, HIF-1alpha knockout mouse embryonic fibroblasts, and db/db mice · source_derived_draft · unverified_draft

    ### hbot-hif-additive Local transfer of stable HIF-1alpha-expressing adenovirus into experimental wounds in db/db mice had an additive effect on the improvements produced by hyperbaric oxygen. Condition category: normal nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Adding more of the sensor on top of the treatment helped further. organism: Mouse tissue_or_cell_type: Dermal fibroblasts and diabetic wounds experimental_model: Human dermal fibroblasts, SKRC7 cells, HIF-1alpha knockout mouse embryonic fibroblasts, and db/db mice limitations: The knockout arm carries the causal claim. The authors describe the stabilisation as non-canonical, so the route from oxygen to HIF stability here is not the classical hydroxylase route. exposure: Hyperbaric oxygen in vitro and in vivo, with adenoviral stable HIF-1alpha delivery evidence_span: {"source_cache": "artifacts/hbot-research/25532619.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bb139ca47291f581e4d45523657f9f244734ce42a3e44c5e460671e58946a3ac", "start_char": 0, "end_char": 1943, "text_sha256": "bb139ca47291f581e4d45523657f9f244734ce42a3e44c5e460671e58946a3ac"} [hbot-p25532619] Hyperbaric oxygen therapy activates hypoxia-inducible factor 1 (HIF-1), which contributes to improved wound healing in diabetic mice. (2015). https://pubmed.ncbi.nlm.nih.gov/25532619/ DOI: 10.1111/wrr.12253
    Complete structured claim and evidence

  2. The review reports that systematic reviews and randomised clinical trials support clinical use of hyperbaric oxygen for refractory diabetic wound healing and radiation injuries, while compromised flaps, grafts and ischaemia-reperfusion disorders are supported by animal studies and a small number of clinical trials.

    Hyperbaric oxygen therapy → Wound healing source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/hbot-research/21200283.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "541f2eb700a843e35093e589069b7839f1a3577c2de8cd1edb444698c1379380", "start_char": 0, "end_char": 1120, "text_sha256": "541f2eb700a843e35093e589069b7839f1a3577c2de8cd1edb444698c1379380"}
    experimental_model
    Narrative review of therapeutic mechanisms and clinical trial evidence
    exposure
    Hyperbaric oxygen as used clinically, typically 2.0 to 2.5 atmospheres absolute
    limitations
    A narrative review, not a primary experiment. It is recorded as the framing source the reader was given; every mechanism it names is also recorded here from its own primary paper.
    nutrient_topic
    Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
    organism
    Human, with supporting animal work
    plain_language
    The evidence is strongest for stubborn diabetic wounds and radiation damage, and thinner elsewhere.
    primary_references
    [hbot-p21200283] Hyperbaric oxygen: its mechanisms and efficacy. (2011). https://pubmed.ncbi.nlm.nih.gov/21200283/ DOI: 10.1097/prs.0b013e3181fbe2bf
    tissue_or_cell_type
    Multiple tissues

    Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 75–86

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Narrative review of therapeutic mechanisms and clinical trial evidence · source_derived_draft · unverified_draft

    ### hbot-review-efficacy-scope The review reports that systematic reviews and randomised clinical trials support clinical use of hyperbaric oxygen for refractory diabetic wound healing and radiation injuries, while compromised flaps, grafts and ischaemia-reperfusion disorders are supported by animal studies and a small number of clinical trials. Condition category: normal nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The evidence is strongest for stubborn diabetic wounds and radiation damage, and thinner elsewhere. organism: Human, with supporting animal work tissue_or_cell_type: Multiple tissues experimental_model: Narrative review of therapeutic mechanisms and clinical trial evidence limitations: A narrative review, not a primary experiment. It is recorded as the framing source the reader was given; every mechanism it names is also recorded here from its own primary paper. exposure: Hyperbaric oxygen as used clinically, typically 2.0 to 2.5 atmospheres absolute evidence_span: {"source_cache": "artifacts/hbot-research/21200283.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "541f2eb700a843e35093e589069b7839f1a3577c2de8cd1edb444698c1379380", "start_char": 0, "end_char": 1120, "text_sha256": "541f2eb700a843e35093e589069b7839f1a3577c2de8cd1edb444698c1379380"} [hbot-p21200283] Hyperbaric oxygen: its mechanisms and efficacy. (2011). https://pubmed.ncbi.nlm.nih.gov/21200283/ DOI: 10.1097/prs.0b013e3181fbe2bf
    Complete structured claim and evidence

  3. The review argues that reactive species of oxygen and nitrogen play a major role in the cell signal transduction cascades through which hyperbaric oxygen mediates wound healing and ameliorates post-ischaemic and inflammatory injuries.

    Reactive oxygen species → Wound healing source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/hbot-research/18845776.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "eb24faa214730ea0aa0cdd25baa8a6ae6481e6b98bd174f0131c0d117b5d828c", "start_char": 0, "end_char": 600, "text_sha256": "eb24faa214730ea0aa0cdd25baa8a6ae6481e6b98bd174f0131c0d117b5d828c"}
    experimental_model
    Narrative review of reactive species in hyperbaric oxygen mechanisms
    exposure
    Clinical hyperbaric oxygen protocols
    limitations
    A second narrative review by the same group. Recorded for its framing claim only; it is not primary evidence for any individual mechanism.
    nutrient_topic
    Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
    organism
    Human and animal
    plain_language
    The same reactive molecules that can damage tissue are the ones carrying the healing signal.
    primary_references
    [hbot-p18845776] Oxidative stress is fundamental to hyperbaric oxygen therapy. (2009). https://pubmed.ncbi.nlm.nih.gov/18845776/ DOI: 10.1152/japplphysiol.91004.2008
    tissue_or_cell_type
    Multiple tissues

    Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 88–99

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Narrative review of reactive species in hyperbaric oxygen mechanisms · source_derived_draft · unverified_draft

    ### hbot-review-oxidative-stress-central The review argues that reactive species of oxygen and nitrogen play a major role in the cell signal transduction cascades through which hyperbaric oxygen mediates wound healing and ameliorates post-ischaemic and inflammatory injuries. Condition category: normal nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The same reactive molecules that can damage tissue are the ones carrying the healing signal. organism: Human and animal tissue_or_cell_type: Multiple tissues experimental_model: Narrative review of reactive species in hyperbaric oxygen mechanisms limitations: A second narrative review by the same group. Recorded for its framing claim only; it is not primary evidence for any individual mechanism. exposure: Clinical hyperbaric oxygen protocols evidence_span: {"source_cache": "artifacts/hbot-research/18845776.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "eb24faa214730ea0aa0cdd25baa8a6ae6481e6b98bd174f0131c0d117b5d828c", "start_char": 0, "end_char": 600, "text_sha256": "eb24faa214730ea0aa0cdd25baa8a6ae6481e6b98bd174f0131c0d117b5d828c"} [hbot-p18845776] Oxidative stress is fundamental to hyperbaric oxygen therapy. (2009). https://pubmed.ncbi.nlm.nih.gov/18845776/ DOI: 10.1152/japplphysiol.91004.2008
    Complete structured claim and evidence

  4. Expression of CD133, CD34, hypoxia inducible factor-1 and thioredoxin-1 in wound margins increased with treatment, and was higher in 2-day-old abdominal wounds than in refractory lower-extremity wounds.

    Hyperbaric oxygen therapy → Wound healing source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/hbot-research/21362081.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a830ae6900d884b73f4e5eac335263db6f9d981a0f95aa45ad3e266c44800e0b", "start_char": 0, "end_char": 1077, "text_sha256": "a830ae6900d884b73f4e5eac335263db6f9d981a0f95aa45ad3e266c44800e0b"}
    experimental_model
    Diabetic patients undergoing hyperbaric oxygen for refractory neuropathic ulcers, with wound margin biopsies
    exposure
    Clinical hyperbaric oxygen therapy courses for refractory lower-extremity ulcers
    limitations
    Human observational measurements within a treatment course, without a randomised comparison. Protein content is measured in the mobilised cells, not in healed tissue.
    nutrient_topic
    Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
    organism
    Human
    plain_language
    More of these cells and proteins turn up at the wound itself, and a fresh wound starts from a better position than a chronic one.
    primary_references
    [hbot-p21362081] Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy. (2011). https://pubmed.ncbi.nlm.nih.gov/21362081/ DOI: 10.1111/j.1524-475x.2010.00660.x
    tissue_or_cell_type
    Peripheral blood, platelets and skin wound margins

    Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 595–606

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Diabetic patients undergoing hyperbaric oxygen for refractory neuropathic ulcers, with wound margin biopsies · source_derived_draft · unverified_draft

    ### hbot-wound-recruitment Expression of CD133, CD34, hypoxia inducible factor-1 and thioredoxin-1 in wound margins increased with treatment, and was higher in 2-day-old abdominal wounds than in refractory lower-extremity wounds. Condition category: normal nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: More of these cells and proteins turn up at the wound itself, and a fresh wound starts from a better position than a chronic one. organism: Human tissue_or_cell_type: Peripheral blood, platelets and skin wound margins experimental_model: Diabetic patients undergoing hyperbaric oxygen for refractory neuropathic ulcers, with wound margin biopsies limitations: Human observational measurements within a treatment course, without a randomised comparison. Protein content is measured in the mobilised cells, not in healed tissue. exposure: Clinical hyperbaric oxygen therapy courses for refractory lower-extremity ulcers evidence_span: {"source_cache": "artifacts/hbot-research/21362081.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a830ae6900d884b73f4e5eac335263db6f9d981a0f95aa45ad3e266c44800e0b", "start_char": 0, "end_char": 1077, "text_sha256": "a830ae6900d884b73f4e5eac335263db6f9d981a0f95aa45ad3e266c44800e0b"} [hbot-p21362081] Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy. (2011). https://pubmed.ncbi.nlm.nih.gov/21362081/ DOI: 10.1111/j.1524-475x.2010.00660.x
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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