{"id":"923be856-9c49-579c-9479-687521b75830","stable_key":"488ea171-36b8-5ef6-b5d3-98563980fdbf:hbot-wound-recruitment","predicate":"increases","statement":"Expression of CD133, CD34, hypoxia inducible factor-1 and thioredoxin-1 in wound margins increased with treatment, and was higher in 2-day-old abdominal wounds than in refractory lower-extremity wounds.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"7600e100-1ebc-5f7c-843f-946f22d0a7b8","mechanism_event_label":"More of these cells and proteins turn up at the wound itself, and a fresh wound starts from a better position than a chronic one.","subject":{"id":"581fa746-cb84-571b-87a0-4d461263f660","slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"},"object":{"id":"cfa217ea-8fe4-5c5a-97ff-469e2ece88c7","slug":"wound-healing","display_name":"Wound healing","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7600e100-1ebc-5f7c-843f-946f22d0a7b8","stable_key":"488ea171-36b8-5ef6-b5d3-98563980fdbf:hbot-wound-recruitment-event","event_type":"observed_intervention","label":"More of these cells and proteins turn up at the wound itself, and a fresh wound starts from a better position than a chronic one.","description":"Expression of CD133, CD34, hypoxia inducible factor-1 and thioredoxin-1 in wound margins increased with treatment, and was higher in 2-day-old abdominal wounds than in refractory lower-extremity wounds.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"581fa746-cb84-571b-87a0-4d461263f660","slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cfa217ea-8fe4-5c5a-97ff-469e2ece88c7","slug":"wound-healing","display_name":"Wound healing","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/hbot-research/21362081.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a830ae6900d884b73f4e5eac335263db6f9d981a0f95aa45ad3e266c44800e0b\", \"start_char\": 0, \"end_char\": 1077, \"text_sha256\": \"a830ae6900d884b73f4e5eac335263db6f9d981a0f95aa45ad3e266c44800e0b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Diabetic patients undergoing hyperbaric oxygen for refractory neuropathic ulcers, with wound margin biopsies","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Clinical hyperbaric oxygen therapy courses for refractory lower-extremity ulcers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Human observational measurements within a treatment course, without a randomised comparison. Protein content is measured in the mobilised cells, not in healed tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"More of these cells and proteins turn up at the wound itself, and a fresh wound starts from a better position than a chronic one.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[hbot-p21362081] Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy. 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Protein content is measured in the mobilised cells, not in healed tissue.\nexposure: Clinical hyperbaric oxygen therapy courses for refractory lower-extremity ulcers\nevidence_span: {\"source_cache\": \"artifacts/hbot-research/21362081.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a830ae6900d884b73f4e5eac335263db6f9d981a0f95aa45ad3e266c44800e0b\", \"start_char\": 0, \"end_char\": 1077, \"text_sha256\": \"a830ae6900d884b73f4e5eac335263db6f9d981a0f95aa45ad3e266c44800e0b\"}\n[hbot-p21362081] Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy. (2011). https://pubmed.ncbi.nlm.nih.gov/21362081/ DOI: 10.1111/j.1524-475x.2010.00660.x","model_system":"Diabetic patients undergoing hyperbaric oxygen for refractory neuropathic ulcers, with wound margin biopsies","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [hbot-p21362081] Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy. 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