{"id":"c6a9fe2d-aac0-5905-9248-d23142432cda","stable_key":"488ea171-36b8-5ef6-b5d3-98563980fdbf:hbot-review-oxidative-stress-central","predicate":"mediates","statement":"The review argues that reactive species of oxygen and nitrogen play a major role in the cell signal transduction cascades through which hyperbaric oxygen mediates wound healing and ameliorates post-ischaemic and inflammatory injuries.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"a3949efa-6af0-579d-b7c3-0ea52044a186","mechanism_event_label":"The same reactive molecules that can damage tissue are the ones carrying the healing signal.","subject":{"id":"b51f3150-efc0-5413-a47a-01d094d248b7","slug":"reactive-oxygen-species","display_name":"Reactive oxygen species","entity_type_key":"chemical_species"},"object":{"id":"cfa217ea-8fe4-5c5a-97ff-469e2ece88c7","slug":"wound-healing","display_name":"Wound healing","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a3949efa-6af0-579d-b7c3-0ea52044a186","stable_key":"488ea171-36b8-5ef6-b5d3-98563980fdbf:hbot-review-oxidative-stress-central-event","event_type":"observed_intervention","label":"The same reactive molecules that can damage tissue are the ones carrying the healing signal.","description":"The review argues that reactive species of oxygen and nitrogen play a major role in the cell signal transduction cascades through which hyperbaric oxygen mediates wound healing and ameliorates post-ischaemic and inflammatory injuries.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b51f3150-efc0-5413-a47a-01d094d248b7","slug":"reactive-oxygen-species","display_name":"Reactive oxygen species","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cfa217ea-8fe4-5c5a-97ff-469e2ece88c7","slug":"wound-healing","display_name":"Wound healing","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/hbot-research/18845776.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"eb24faa214730ea0aa0cdd25baa8a6ae6481e6b98bd174f0131c0d117b5d828c\", \"start_char\": 0, \"end_char\": 600, \"text_sha256\": \"eb24faa214730ea0aa0cdd25baa8a6ae6481e6b98bd174f0131c0d117b5d828c\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Narrative review of reactive species in hyperbaric oxygen mechanisms","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Clinical hyperbaric oxygen protocols","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A second narrative review by the same group. Recorded for its framing claim only; it is not primary evidence for any individual mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human and animal","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The same reactive molecules that can damage tissue are the ones carrying the healing signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[hbot-p18845776] Oxidative stress is fundamental to hyperbaric oxygen therapy. (2009). https://pubmed.ncbi.nlm.nih.gov/18845776/ DOI: 10.1152/japplphysiol.91004.2008","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Multiple tissues","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"74b8b233-23b8-54e1-afd5-fd04e38890fb","evidence_kind":"source_excerpt","locator":"Lines 88-99","start_line":88,"end_line":99,"excerpt":"### hbot-review-oxidative-stress-central\nThe review argues that reactive species of oxygen and nitrogen play a major role in the cell signal transduction cascades through which hyperbaric oxygen mediates wound healing and ameliorates post-ischaemic and inflammatory injuries.\nCondition category: normal\nnutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.\nplain_language: The same reactive molecules that can damage tissue are the ones carrying the healing signal.\norganism: Human and animal\ntissue_or_cell_type: Multiple tissues\nexperimental_model: Narrative review of reactive species in hyperbaric oxygen mechanisms\nlimitations: A second narrative review by the same group. Recorded for its framing claim only; it is not primary evidence for any individual mechanism.\nexposure: Clinical hyperbaric oxygen protocols\nevidence_span: {\"source_cache\": \"artifacts/hbot-research/18845776.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"eb24faa214730ea0aa0cdd25baa8a6ae6481e6b98bd174f0131c0d117b5d828c\", \"start_char\": 0, \"end_char\": 600, \"text_sha256\": \"eb24faa214730ea0aa0cdd25baa8a6ae6481e6b98bd174f0131c0d117b5d828c\"}\n[hbot-p18845776] Oxidative stress is fundamental to hyperbaric oxygen therapy. (2009). https://pubmed.ncbi.nlm.nih.gov/18845776/ DOI: 10.1152/japplphysiol.91004.2008","model_system":"Narrative review of reactive species in hyperbaric oxygen mechanisms","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [hbot-p18845776] Oxidative stress is fundamental to hyperbaric oxygen therapy. (2009). https://pubmed.ncbi.nlm.nih.gov/18845776/ DOI: 10.1152/japplphysiol.91004.2008","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dbf39b48-c95e-5291-b404-349ffbc4488f","stable_key":"import-488ea171-36b8-5ef6-b5d3-98563980fdbf","title":"Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"fb2443321804010d82c6b96ab61cc51b4b6628ddbb15751cb0e90b491606e79c","revision_id":"bb699ea5-b492-5728-b22c-48f0842a8ac9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}