Component

Whole-blood manganese concentration

Whole-blood manganese concentration. Experimental scope belongs to each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. After more frequent chelation and added ferrous fumarate, blood manganese, MRI and liver findings improved; later iron dosing was reduced after serum iron rose excessively.

    Manganese chelation with added oral iron → Whole-blood manganese concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    Ferrous fumarate (added_treatment); Calcium disodium edetate (concurrent_treatment); Iron (interacting_nutrient); Manganese (affected_nutrient)
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/stamelou2012.txt", "locator": "Clinical description; age 15–16 treatment changes", "file_sha256": "5d86a26fe564508fb382d1c8df61f531bfbaf06b69e2078b0999e3a3129555f6", "start_char": 9842, "end_char": 10521, "text_sha256": "2da91cbaa297984ac1c90caf8701ce0a3f9a633b806ef4fff178b6ecc46c8aa1", "text_characters": 679}
    experimental_model
    Ten-year longitudinal report of one SLC30A10 patient
    exposure
    Calcium disodium edetate chelation; subsequent increase in chelation frequency and addition of oral ferrous fumarate.
    limitations
    Repeated observations in one previously described patient. Combined treatment changes prevent attribution of later benefit to iron alone; disease-specific treatment is not routine nutrient replacement.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    The combined regimen affected both manganese removal and iron status.
    primary_references
    [mn-clin-stamelou2012] Dystonia with brain manganese accumulation resulting from SLC30A10 mutations: a new treatable disorder. (2012). https://pubmed.ncbi.nlm.nih.gov/22926781/ DOI: 10.1002/mds.25138
    tissue_or_cell_type
    Urine, blood, brain MRI and motor function
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1314–1326

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Ten-year longitudinal report of one SLC30A10 patient · source_derived_draft · unverified_draft

    ### mn-clin-iron-chelation-combination After more frequent chelation and added ferrous fumarate, blood manganese, MRI and liver findings improved; later iron dosing was reduced after serum iron rose excessively. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: The combined regimen affected both manganese removal and iron status. organism: Homo sapiens tissue_or_cell_type: Urine, blood, brain MRI and motor function experimental_model: Ten-year longitudinal report of one SLC30A10 patient limitations: Repeated observations in one previously described patient. Combined treatment changes prevent attribution of later benefit to iron alone; disease-specific treatment is not routine nutrient replacement. exposure: Calcium disodium edetate chelation; subsequent increase in chelation frequency and addition of oral ferrous fumarate. cross_nutrient: Ferrous fumarate (added_treatment); Calcium disodium edetate (concurrent_treatment); Iron (interacting_nutrient); Manganese (affected_nutrient) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/stamelou2012.txt", "locator": "Clinical description; age 15–16 treatment changes", "file_sha256": "5d86a26fe564508fb382d1c8df61f531bfbaf06b69e2078b0999e3a3129555f6", "start_char": 9842, "end_char": 10521, "text_sha256": "2da91cbaa297984ac1c90caf8701ce0a3f9a633b806ef4fff178b6ecc46c8aa1", "text_characters": 679} [mn-clin-stamelou2012] Dystonia with brain manganese accumulation resulting from SLC30A10 mutations: a new treatable disorder. (2012). https://pubmed.ncbi.nlm.nih.gov/22926781/ DOI: 10.1002/mds.25138
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Chelation increased urinary manganese and reduced blood manganese in the followed SLC30A10 patient.

    Calcium disodium edetate → Urinary manganese excretion source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    Whole-blood manganese concentration (reduced_endpoint); Manganese (removed_nutrient)
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/stamelou2012.txt", "locator": "Clinical description; initial calcium disodium edetate treatment", "file_sha256": "5d86a26fe564508fb382d1c8df61f531bfbaf06b69e2078b0999e3a3129555f6", "start_char": 8926, "end_char": 9841, "text_sha256": "0bc6daa528aab341fb9d91dc543811ba24f7f8e904f084c085bafc1d4093113e", "text_characters": 915}
    experimental_model
    Ten-year longitudinal report of one SLC30A10 patient
    exposure
    Calcium disodium edetate chelation; subsequent increase in chelation frequency and addition of oral ferrous fumarate.
    limitations
    Repeated observations in one previously described patient. Combined treatment changes prevent attribution of later benefit to iron alone; disease-specific treatment is not routine nutrient replacement.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    The treatment moved more manganese into urine.
    primary_references
    [mn-clin-stamelou2012] Dystonia with brain manganese accumulation resulting from SLC30A10 mutations: a new treatable disorder. (2012). https://pubmed.ncbi.nlm.nih.gov/22926781/ DOI: 10.1002/mds.25138
    tissue_or_cell_type
    Urine, blood, brain MRI and motor function
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1272–1284

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Ten-year longitudinal report of one SLC30A10 patient · source_derived_draft · unverified_draft

    ### mn-clin-chelation-manganese-removal Chelation increased urinary manganese and reduced blood manganese in the followed SLC30A10 patient. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: The treatment moved more manganese into urine. organism: Homo sapiens tissue_or_cell_type: Urine, blood, brain MRI and motor function experimental_model: Ten-year longitudinal report of one SLC30A10 patient limitations: Repeated observations in one previously described patient. Combined treatment changes prevent attribution of later benefit to iron alone; disease-specific treatment is not routine nutrient replacement. exposure: Calcium disodium edetate chelation; subsequent increase in chelation frequency and addition of oral ferrous fumarate. cross_nutrient: Whole-blood manganese concentration (reduced_endpoint); Manganese (removed_nutrient) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/stamelou2012.txt", "locator": "Clinical description; initial calcium disodium edetate treatment", "file_sha256": "5d86a26fe564508fb382d1c8df61f531bfbaf06b69e2078b0999e3a3129555f6", "start_char": 8926, "end_char": 9841, "text_sha256": "0bc6daa528aab341fb9d91dc543811ba24f7f8e904f084c085bafc1d4093113e", "text_characters": 915} [mn-clin-stamelou2012] Dystonia with brain manganese accumulation resulting from SLC30A10 mutations: a new treatable disorder. (2012). https://pubmed.ncbi.nlm.nih.gov/22926781/ DOI: 10.1002/mds.25138
    Complete structured claim and evidence

  2. Whole-blood manganese and pallidal T1-weighted MRI signal changed with manganese administration and withdrawal; their correlation was r=0.7693.

    Parenteral manganese administration → Globus pallidus T1-weighted MRI signal source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Whole-blood manganese concentration (correlated_marker); Manganese (administered_nutrient)
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/takagi2001.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c", "start_char": 0, "end_char": 1726, "text_sha256": "e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c", "text_characters": 1726}
    experimental_model
    On-off manganese study in 11 adults on home parenteral nutrition
    exposure
    Parenteral nutrition containing 0 or 20 micromoles Mn/day; serial blood and MRI measurements.
    limitations
    Intravenous exposure bypasses intestinal regulation. T1-weighted signal is a deposition-related marker, not by itself proof of neurological disability or a general dietary threshold.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    Blood and brain imaging responded together under this intravenous exposure.
    primary_references
    [mn-clin-takagi2001] On-off study of manganese administration to adult patients undergoing home parenteral nutrition: new indices of in vivo manganese level. (2001). https://pubmed.ncbi.nlm.nih.gov/11284475/ DOI: 10.1177/014860710102500287
    tissue_or_cell_type
    Whole blood and brain MRI

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1328–1340

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · On-off manganese study in 11 adults on home parenteral nutrition · source_derived_draft · unverified_draft

    ### mn-clin-parenteral-marker-response Whole-blood manganese and pallidal T1-weighted MRI signal changed with manganese administration and withdrawal; their correlation was r=0.7693. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Blood and brain imaging responded together under this intravenous exposure. organism: Homo sapiens tissue_or_cell_type: Whole blood and brain MRI experimental_model: On-off manganese study in 11 adults on home parenteral nutrition limitations: Intravenous exposure bypasses intestinal regulation. T1-weighted signal is a deposition-related marker, not by itself proof of neurological disability or a general dietary threshold. exposure: Parenteral nutrition containing 0 or 20 micromoles Mn/day; serial blood and MRI measurements. cross_nutrient: Whole-blood manganese concentration (correlated_marker); Manganese (administered_nutrient) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/takagi2001.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c", "start_char": 0, "end_char": 1726, "text_sha256": "e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c", "text_characters": 1726} [mn-clin-takagi2001] On-off study of manganese administration to adult patients undergoing home parenteral nutrition: new indices of in vivo manganese level. (2001). https://pubmed.ncbi.nlm.nih.gov/11284475/ DOI: 10.1177/014860710102500287
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards