Globus pallidus T1-weighted MRI signal: molecular mechanisms & dependencies

How nutrients influence it

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Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

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What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

Whole-blood manganese and pallidal T1-weighted MRI signal changed with manganese administration and withdrawal; their correlation was r=0.7693.
Parenteral manganese administration → Globus pallidus T1-weighted MRI signal source_derived_draftungraded
Experimental context and source evidence
cross_nutrient
Whole-blood manganese concentration (correlated_marker); Manganese (administered_nutrient)
evidence_span
{"source_cache": "artifacts/manganese-clinical-sources/takagi2001.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c", "start_char": 0, "end_char": 1726, "text_sha256": "e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c", "text_characters": 1726}
experimental_model
On-off manganese study in 11 adults on home parenteral nutrition
exposure
Parenteral nutrition containing 0 or 20 micromoles Mn/day; serial blood and MRI measurements.
limitations
Intravenous exposure bypasses intestinal regulation. T1-weighted signal is a deposition-related marker, not by itself proof of neurological disability or a general dietary threshold.
nutrient_topic
Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
organism
Homo sapiens
plain_language
Blood and brain imaging responded together under this intravenous exposure.
primary_references
[mn-clin-takagi2001] On-off study of manganese administration to adult patients undergoing home parenteral nutrition: new indices of in vivo manganese level. (2001). https://pubmed.ncbi.nlm.nih.gov/11284475/ DOI: 10.1177/014860710102500287
tissue_or_cell_type
Whole blood and brain MRI
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1328–1340
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · On-off manganese study in 11 adults on home parenteral nutrition · source_derived_draft · unverified_draft
### mn-clin-parenteral-marker-response Whole-blood manganese and pallidal T1-weighted MRI signal changed with manganese administration and withdrawal; their correlation was r=0.7693. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Blood and brain imaging responded together under this intravenous exposure. organism: Homo sapiens tissue_or_cell_type: Whole blood and brain MRI experimental_model: On-off manganese study in 11 adults on home parenteral nutrition limitations: Intravenous exposure bypasses intestinal regulation. T1-weighted signal is a deposition-related marker, not by itself proof of neurological disability or a general dietary threshold. exposure: Parenteral nutrition containing 0 or 20 micromoles Mn/day; serial blood and MRI measurements. cross_nutrient: Whole-blood manganese concentration (correlated_marker); Manganese (administered_nutrient) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/takagi2001.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c", "start_char": 0, "end_char": 1726, "text_sha256": "e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c", "text_characters": 1726} [mn-clin-takagi2001] On-off study of manganese administration to adult patients undergoing home parenteral nutrition: new indices of in vivo manganese level. (2001). https://pubmed.ncbi.nlm.nih.gov/11284475/ DOI: 10.1177/014860710102500287
Complete structured claim and evidence
The increased T1-weighted signal took at least five months to disappear after manganese withdrawal.
Parenteral manganese administration → Globus pallidus T1-weighted MRI signal source_derived_draftungraded
Experimental context and source evidence
cross_nutrient
Manganese (withdrawn_nutrient)
evidence_span
{"source_cache": "artifacts/manganese-clinical-sources/takagi2001.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c", "start_char": 0, "end_char": 1726, "text_sha256": "e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c", "text_characters": 1726}
experimental_model
On-off manganese study in 11 adults on home parenteral nutrition
exposure
Parenteral nutrition containing 0 or 20 micromoles Mn/day; serial blood and MRI measurements.
limitations
Intravenous exposure bypasses intestinal regulation. T1-weighted signal is a deposition-related marker, not by itself proof of neurological disability or a general dietary threshold.
nutrient_topic
Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
organism
Homo sapiens
plain_language
A brain exposure marker could take months to return toward normal.
primary_references
[mn-clin-takagi2001] On-off study of manganese administration to adult patients undergoing home parenteral nutrition: new indices of in vivo manganese level. (2001). https://pubmed.ncbi.nlm.nih.gov/11284475/ DOI: 10.1177/014860710102500287
tissue_or_cell_type
Whole blood and brain MRI
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1342–1354
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · On-off manganese study in 11 adults on home parenteral nutrition · source_derived_draft · unverified_draft
### mn-clin-parenteral-mri-recovery The increased T1-weighted signal took at least five months to disappear after manganese withdrawal. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: A brain exposure marker could take months to return toward normal. organism: Homo sapiens tissue_or_cell_type: Whole blood and brain MRI experimental_model: On-off manganese study in 11 adults on home parenteral nutrition limitations: Intravenous exposure bypasses intestinal regulation. T1-weighted signal is a deposition-related marker, not by itself proof of neurological disability or a general dietary threshold. exposure: Parenteral nutrition containing 0 or 20 micromoles Mn/day; serial blood and MRI measurements. cross_nutrient: Manganese (withdrawn_nutrient) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/takagi2001.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c", "start_char": 0, "end_char": 1726, "text_sha256": "e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c", "text_characters": 1726} [mn-clin-takagi2001] On-off study of manganese administration to adult patients undergoing home parenteral nutrition: new indices of in vivo manganese level. (2001). https://pubmed.ncbi.nlm.nih.gov/11284475/ DOI: 10.1177/014860710102500287
Complete structured claim and evidence

Where it participates (unsigned role)

Dystonia and brain MRI abnormalities improved during the longitudinal chelation treatment.
Calcium disodium edetate → Dystonia severity source_derived_draftungraded
Experimental context and source evidence
availability_state
machinery_impairment Imported condition classification; unverified.
cross_nutrient
Globus pallidus T1-weighted MRI signal (associated_endpoint)
evidence_span
{"source_cache": "artifacts/manganese-clinical-sources/stamelou2012.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "78edd20dcd2eaffac255ea725a64825ca18850475d25c7c29599b04351a52d12", "start_char": 0, "end_char": 1183, "text_sha256": "78edd20dcd2eaffac255ea725a64825ca18850475d25c7c29599b04351a52d12", "text_characters": 1183}
experimental_model
Ten-year longitudinal report of one SLC30A10 patient
exposure
Calcium disodium edetate chelation; subsequent increase in chelation frequency and addition of oral ferrous fumarate.
limitations
Repeated observations in one previously described patient. Combined treatment changes prevent attribution of later benefit to iron alone; disease-specific treatment is not routine nutrient replacement.
nutrient_topic
Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
organism
Homo sapiens
plain_language
Removing accumulated manganese was accompanied by improved movement and imaging.
primary_references
[mn-clin-stamelou2012] Dystonia with brain manganese accumulation resulting from SLC30A10 mutations: a new treatable disorder. (2012). https://pubmed.ncbi.nlm.nih.gov/22926781/ DOI: 10.1002/mds.25138
tissue_or_cell_type
Urine, blood, brain MRI and motor function
trigger_kind
machinery_impairment Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1286–1298
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Ten-year longitudinal report of one SLC30A10 patient · source_derived_draft · unverified_draft
### mn-clin-chelation-clinical Dystonia and brain MRI abnormalities improved during the longitudinal chelation treatment. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Removing accumulated manganese was accompanied by improved movement and imaging. organism: Homo sapiens tissue_or_cell_type: Urine, blood, brain MRI and motor function experimental_model: Ten-year longitudinal report of one SLC30A10 patient limitations: Repeated observations in one previously described patient. Combined treatment changes prevent attribution of later benefit to iron alone; disease-specific treatment is not routine nutrient replacement. exposure: Calcium disodium edetate chelation; subsequent increase in chelation frequency and addition of oral ferrous fumarate. cross_nutrient: Globus pallidus T1-weighted MRI signal (associated_endpoint) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/stamelou2012.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "78edd20dcd2eaffac255ea725a64825ca18850475d25c7c29599b04351a52d12", "start_char": 0, "end_char": 1183, "text_sha256": "78edd20dcd2eaffac255ea725a64825ca18850475d25c7c29599b04351a52d12", "text_characters": 1183} [mn-clin-stamelou2012] Dystonia with brain manganese accumulation resulting from SLC30A10 mutations: a new treatable disorder. (2012). https://pubmed.ncbi.nlm.nih.gov/22926781/ DOI: 10.1002/mds.25138
Complete structured claim and evidence

The events it takes part in

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Situations it appears in

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In the sources

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Open hypotheses

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This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Globus pallidus T1-weighted MRI signal

How nutrients influence it

Other things that act on it