{"id":"f538e088-7a37-571b-936e-62b39beb49ae","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-parenteral-mri-recovery","predicate":"withdrawal_reversed","statement":"The increased T1-weighted signal took at least five months to disappear after manganese withdrawal.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"375995de-7f59-5e86-bd31-4ad82546a2c0","mechanism_event_label":"A brain exposure marker could take months to return toward normal.","subject":{"id":"e62c76f5-81f6-5deb-bae0-3443455957a8","slug":"parenteral-manganese-administration","display_name":"Parenteral manganese administration","entity_type_key":"cellular_process"},"object":{"id":"0e99df84-33e7-5228-972c-a4fab8514ac9","slug":"pallidal-t1-mri-signal","display_name":"Globus pallidus T1-weighted MRI signal","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"375995de-7f59-5e86-bd31-4ad82546a2c0","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-parenteral-mri-recovery-event","event_type":"observed_intervention","label":"A brain exposure marker could take months to return toward normal.","description":"The increased T1-weighted signal took at least five months to disappear after manganese withdrawal.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f0459455-8231-513b-8214-7ea5b3259b4b","slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"},"role":"withdrawn_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e62c76f5-81f6-5deb-bae0-3443455957a8","slug":"parenteral-manganese-administration","display_name":"Parenteral manganese administration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0e99df84-33e7-5228-972c-a4fab8514ac9","slug":"pallidal-t1-mri-signal","display_name":"Globus pallidus T1-weighted MRI signal","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Manganese (withdrawn_nutrient)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/manganese-clinical-sources/takagi2001.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c\", \"start_char\": 0, \"end_char\": 1726, \"text_sha256\": \"e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c\", \"text_characters\": 1726}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"On-off manganese study in 11 adults on home parenteral nutrition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Parenteral nutrition containing 0 or 20 micromoles Mn/day; serial blood and MRI measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Intravenous exposure bypasses intestinal regulation. T1-weighted signal is a deposition-related marker, not by itself proof of neurological disability or a general dietary threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A brain exposure marker could take months to return toward normal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-clin-takagi2001] On-off study of manganese administration to adult patients undergoing home parenteral nutrition: new indices of in vivo manganese level. (2001). https://pubmed.ncbi.nlm.nih.gov/11284475/ DOI: 10.1177/014860710102500287","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole blood and brain MRI","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b8b5475f-771d-5120-95d3-dd221da11c8f","evidence_kind":"source_excerpt","locator":"Lines 1342-1354","start_line":1342,"end_line":1354,"excerpt":"### mn-clin-parenteral-mri-recovery\nThe increased T1-weighted signal took at least five months to disappear after manganese withdrawal.\nCondition category: normal\nnutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A brain exposure marker could take months to return toward normal.\norganism: Homo sapiens\ntissue_or_cell_type: Whole blood and brain MRI\nexperimental_model: On-off manganese study in 11 adults on home parenteral nutrition\nlimitations: Intravenous exposure bypasses intestinal regulation. T1-weighted signal is a deposition-related marker, not by itself proof of neurological disability or a general dietary threshold.\nexposure: Parenteral nutrition containing 0 or 20 micromoles Mn/day; serial blood and MRI measurements.\ncross_nutrient: Manganese (withdrawn_nutrient)\nevidence_span: {\"source_cache\": \"artifacts/manganese-clinical-sources/takagi2001.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c\", \"start_char\": 0, \"end_char\": 1726, \"text_sha256\": \"e5336a20271762ff7375cfe777c71c9b721c68bc47ae09e9a36b8eaac2953b8c\", \"text_characters\": 1726}\n[mn-clin-takagi2001] On-off study of manganese administration to adult patients undergoing home parenteral nutrition: new indices of in vivo manganese level. 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