Component
Anticoagulant response to warfarin
Anticoagulant response to warfarin. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The case report described reduced warfarin responsiveness during CoQ use and recovery after withdrawal.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coq10-research/9621803.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "510d412753fc2f3ff7e974beda97125c6112e530d6379145495e56fa01adb498", "start_char": 0, "end_char": 752, "text_sha256": "510d412753fc2f3ff7e974beda97125c6112e530d6379145495e56fa01adb498"}
- experimental_model
- Case report with supplement withdrawal
- exposure
- CoQ10 exposure then discontinuation
- limitations
- Single case; temporal association is not proof of mechanism or interaction frequency. Chemical similarity does not establish vitamin K activity.
- nutrient_topic
- Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
- organism
- 72-year-old woman taking warfarin
- plain_language
- A possible drug interaction was reported, but one case cannot determine how often it occurs.
- primary_references
- [coq10-p9621803] [Interaction between warfarin and coenzyme Q10]. (1998). https://pubmed.ncbi.nlm.nih.gov/9621803/
- tissue_or_cell_type
- Anticoagulant response
Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 1256–1267
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Case report with supplement withdrawal · source_derived_draft · unverified_draft
### coq10-warfarin-case The case report described reduced warfarin responsiveness during CoQ use and recovery after withdrawal. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A possible drug interaction was reported, but one case cannot determine how often it occurs. organism: 72-year-old woman taking warfarin tissue_or_cell_type: Anticoagulant response experimental_model: Case report with supplement withdrawal limitations: Single case; temporal association is not proof of mechanism or interaction frequency. Chemical similarity does not establish vitamin K activity. exposure: CoQ10 exposure then discontinuation evidence_span: {"source_cache": "artifacts/coq10-research/9621803.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "510d412753fc2f3ff7e974beda97125c6112e530d6379145495e56fa01adb498", "start_char": 0, "end_char": 752, "text_sha256": "510d412753fc2f3ff7e974beda97125c6112e530d6379145495e56fa01adb498"} [coq10-p9621803] [Interaction between warfarin and coenzyme Q10]. (1998). https://pubmed.ncbi.nlm.nih.gov/9621803/
Complete structured claim and evidenceCo-administered ginger product did not significantly change the INR response to a single warfarin dose in healthy men.
Experimental context and source evidence
- dose
- Warfarin 25 mg once; ginger product at recommended study dose, exact herbal amount not in accessed abstract
- duration
- Ginger for 7 days before and 7 days after warfarin
- evidence_access
- Primary PubMed abstract.
- evidence_scope
- literature_reviewed; model-specific source-derived curation, not universally established human effects
- experimental_model
- 12 healthy men in an open randomized three-way crossover study
- limitations
- Whole ginger rather than purified gingerols; a small healthy-volunteer null result cannot exclude interactions during chronic anticoagulation.
- nutrient_topic
- Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
- organism
- 12 healthy men in an open randomized three-way crossover study
- plain_language
- Co-administered ginger product did not significantly change the INR response to a single warfarin dose in healthy men.
- primary_references
- Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. (2005). https://pubmed.ncbi.nlm.nih.gov/15801937/ DOI: 10.1111/j.1365-2125.2005.02322.x
- route
- Oral co-exposure
- tissue
- Plasma and coagulation measurements
Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 558–567
Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · 12 healthy men in an open randomized three-way crossover study · source_derived_draft · unverified_draft
## gingerols-ginger-warfarin-inr-null Co-administered ginger product did not significantly change the INR response to a single warfarin dose in healthy men. Model/species: 12 healthy men in an open randomized three-way crossover study Tissue: Plasma and coagulation measurements Exposure: Warfarin 25 mg once; ginger product at recommended study dose, exact herbal amount not in accessed abstract Route: Oral co-exposure Duration: Ginger for 7 days before and 7 days after warfarin Limits: Whole ginger rather than purified gingerols; a small healthy-volunteer null result cannot exclude interactions during chronic anticoagulation. Primary reference: Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. (2005). https://pubmed.ncbi.nlm.nih.gov/15801937/ DOI: 10.1111/j.1365-2125.2005.02322.x Access: Primary PubMed abstract.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.