{"id":"8e52a4e8-2c03-5cf2-8307-67bf4291081c","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-warfarin-case","predicate":"temporally_associated_with_reduced","statement":"The case report described reduced warfarin responsiveness during CoQ use and recovery after withdrawal.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ae040a7f-e7e5-5bac-96f1-213f2f13bf71","mechanism_event_label":"A possible drug interaction was reported, but one case cannot determine how often it occurs.","subject":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"object":{"id":"73dec95c-aa04-567b-b50e-e0ddfe5f0fa6","slug":"warfarin-anticoagulant-response","display_name":"Anticoagulant response to warfarin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ae040a7f-e7e5-5bac-96f1-213f2f13bf71","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-warfarin-case-event","event_type":"observed_intervention","label":"A possible drug interaction was reported, but one case cannot determine how often it occurs.","description":"The case report described reduced warfarin responsiveness during CoQ use and recovery after withdrawal.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ee94b256-deeb-5795-8b6e-6e388576d464","slug":"warfarin","display_name":"Warfarin","entity_type_key":"small_molecule"},"role":"concurrent_drug","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"73dec95c-aa04-567b-b50e-e0ddfe5f0fa6","slug":"warfarin-anticoagulant-response","display_name":"Anticoagulant response to warfarin","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/9621803.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"510d412753fc2f3ff7e974beda97125c6112e530d6379145495e56fa01adb498\", \"start_char\": 0, \"end_char\": 752, \"text_sha256\": \"510d412753fc2f3ff7e974beda97125c6112e530d6379145495e56fa01adb498\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Case report with supplement withdrawal","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"CoQ10 exposure then discontinuation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Single case; temporal association is not proof of mechanism or interaction frequency. Chemical similarity does not establish vitamin K activity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"72-year-old woman taking warfarin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A possible drug interaction was reported, but one case cannot determine how often it occurs.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p9621803] [Interaction between warfarin and coenzyme Q10]. (1998). https://pubmed.ncbi.nlm.nih.gov/9621803/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Anticoagulant response","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a61a6163-4c84-533e-ad74-7484514b3824","evidence_kind":"source_excerpt","locator":"Lines 1256-1267","start_line":1256,"end_line":1267,"excerpt":"### coq10-warfarin-case\nThe case report described reduced warfarin responsiveness during CoQ use and recovery after withdrawal.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A possible drug interaction was reported, but one case cannot determine how often it occurs.\norganism: 72-year-old woman taking warfarin\ntissue_or_cell_type: Anticoagulant response\nexperimental_model: Case report with supplement withdrawal\nlimitations: Single case; temporal association is not proof of mechanism or interaction frequency. Chemical similarity does not establish vitamin K activity.\nexposure: CoQ10 exposure then discontinuation\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/9621803.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"510d412753fc2f3ff7e974beda97125c6112e530d6379145495e56fa01adb498\", \"start_char\": 0, \"end_char\": 752, \"text_sha256\": \"510d412753fc2f3ff7e974beda97125c6112e530d6379145495e56fa01adb498\"}\n[coq10-p9621803] [Interaction between warfarin and coenzyme Q10]. (1998). https://pubmed.ncbi.nlm.nih.gov/9621803/","model_system":"Case report with supplement withdrawal","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [coq10-p9621803] [Interaction between warfarin and coenzyme Q10]. (1998). https://pubmed.ncbi.nlm.nih.gov/9621803/","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fc6c2f3b-14a3-59de-848e-ca1c02fee1df","stable_key":"import-3b5aff9b-4086-5574-bfb4-3ea49ba520d7","title":"Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"053f9a6f6c17321fa9fd271486d7f20a86a49b237424108de7dc8663372e73bf","revision_id":"028900ce-8ca4-5d13-8c86-6e327c071e64","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}