Component
Human UDP-glucuronosyltransferase 1A3 / UGT1A3
Human UDP-glucuronosyltransferase 1A3 / UGT1A3. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
UGT1A3 contributed alongside UGT2B7 to steviol glucuronidation at high substrate concentration.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Recombinant human enzyme screening and microsomal kinetics.
- limitations
- High versus low assay concentration must not be converted into an unmeasured dietary threshold.
- nutrient_topic
- Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
- plain_language
- The participating enzyme mix changes with substrate concentration.
- primary_references
- Steviol glucuronidation and its potential interaction with UDP-glucuronosyltransferase 2B7 substrates. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24296138/ · DOI 10.1016/j.fct.2013.11.028
Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 58–64
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Recombinant human enzyme screening and microsomal kinetics. · source_derived_draft · unverified_draft
## stevia-ugt1a3 The participating enzyme mix changes with substrate concentration. UGT1A3 contributed alongside UGT2B7 to steviol glucuronidation at high substrate concentration. Model: Recombinant human enzyme screening and microsomal kinetics. Limitations: High versus low assay concentration must not be converted into an unmeasured dietary threshold. Evidence access: Primary abstract Steviol glucuronidation and its potential interaction with UDP-glucuronosyltransferase 2B7 substrates. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24296138/ · DOI 10.1016/j.fct.2013.11.028
Complete structured claim and evidence
What acts on it
Norathyriol competitively inhibited UGT1A3; IC50 8.2 and Ki 1.6 micromolar.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mangiferin-research/28621744.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e2741f9036a84104809f4d9813afeb1603b3e93e1d247ea0e4b5ff31be0e1ae5", "start_char": 0, "end_char": 1562, "text_sha256": "e2741f9036a84104809f4d9813afeb1603b3e93e1d247ea0e4b5ff31be0e1ae5"}
- experimental_model
- Recombinant UGT inhibition kinetics
- exposure
- Micromolar norathyriol; initial comparison at 100 micromolar
- limitations
- Probe-dependent biochemical inhibition; no established human interaction threshold. Docking is not additional proof of binding in vivo.
- nutrient_topic
- Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
- organism
- Recombinant enzyme assay
- plain_language
- The aglycone has its own conjugation-enzyme interaction profile.
- primary_references
- [mangiferin-p28621744] In Vitro Comparative Study of the Inhibitory Effects of Mangiferin and Its Aglycone Norathyriol towards UDP-Glucuronosyl Transferase (UGT) Isoforms. (2017). https://pubmed.ncbi.nlm.nih.gov/28621744/ DOI: 10.3390/molecules22061008
- tissue_or_cell_type
- 4-methylumbelliferone glucuronidation
Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 874–885
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant UGT inhibition kinetics · source_derived_draft · unverified_draft
### mangiferin-norathyriol-ugt1a3 Norathyriol competitively inhibited UGT1A3; IC50 8.2 and Ki 1.6 micromolar. Condition category: normal nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The aglycone has its own conjugation-enzyme interaction profile. organism: Recombinant enzyme assay tissue_or_cell_type: 4-methylumbelliferone glucuronidation experimental_model: Recombinant UGT inhibition kinetics limitations: Probe-dependent biochemical inhibition; no established human interaction threshold. Docking is not additional proof of binding in vivo. exposure: Micromolar norathyriol; initial comparison at 100 micromolar evidence_span: {"source_cache": "artifacts/mangiferin-research/28621744.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e2741f9036a84104809f4d9813afeb1603b3e93e1d247ea0e4b5ff31be0e1ae5", "start_char": 0, "end_char": 1562, "text_sha256": "e2741f9036a84104809f4d9813afeb1603b3e93e1d247ea0e4b5ff31be0e1ae5"} [mangiferin-p28621744] In Vitro Comparative Study of the Inhibitory Effects of Mangiferin and Its Aglycone Norathyriol towards UDP-Glucuronosyl Transferase (UGT) Isoforms. (2017). https://pubmed.ncbi.nlm.nih.gov/28621744/ DOI: 10.3390/molecules22061008
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.