Component

Human sodium/hydrogen exchanger 3 / SLC9A3

Human sodium/hydrogen exchanger 3 / SLC9A3. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Butyrate increased apical NHE3 protein and sodium/hydrogen exchange activity in human C2/bbe monolayers, while NHE2 did not increase.

    Butyrate → Human sodium/hydrogen exchanger 3 / SLC9A3 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human colonic-cell exposure experiments.
    limitations
    The separate pectin-fed rat arm is not an isolated human butyrate intervention or proof of net whole-body sodium retention.
    nutrient_topic
    Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
    plain_language
    It changed machinery that supports intestinal sodium absorption.
    primary_references
    SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11254495/ · DOI 10.1152/ajpgi.2001.280.4.G687

    Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 150–156

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human colonic-cell exposure experiments. · source_derived_draft · unverified_draft

    ## butyrate-nhe3-sodium It changed machinery that supports intestinal sodium absorption. Butyrate increased apical NHE3 protein and sodium/hydrogen exchange activity in human C2/bbe monolayers, while NHE2 did not increase. Model: Human colonic-cell exposure experiments. Limitations: The separate pectin-fed rat arm is not an isolated human butyrate intervention or proof of net whole-body sodium retention. Evidence access: Primary abstract SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11254495/ · DOI 10.1152/ajpgi.2001.280.4.G687
    Complete structured claim and evidence

  2. Tenapanor inhibits intestinal NHE3, the sodium/hydrogen exchanger targeted in the phosphate-absorption study.

    Tenapanor → Human sodium/hydrogen exchanger 3 / SLC9A3 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/30158152.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e", "start_char": 0, "end_char": 1701, "text_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e"}
    experimental_model
    Rodent physiology, human enteroid transport and healthy-volunteer intervention
    exposure
    Enteroid NHE3 perturbation; healthy volunteers 15 mg tenapanor twice daily for four days
    limitations
    Tenapanor inhibits NHE3 rather than binding phosphate. TEER is an epithelial assay measure, not a direct clinical permeability score.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Human-derived intestinal epithelial system
    plain_language
    A sodium-handling protein can change how phosphate crosses the gut wall.
    primary_references
    [phosphorus-p30158152] Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. (2018). https://pubmed.ncbi.nlm.nih.gov/30158152/ DOI: 10.1126/scitranslmed.aam6474
    tissue_or_cell_type
    Intestinal epithelium; stool and urinary balance

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 321–332

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rodent physiology, human enteroid transport and healthy-volunteer intervention · source_derived_draft · unverified_draft

    ### phosphorus-tenapanor-nhe3 Tenapanor inhibits intestinal NHE3, the sodium/hydrogen exchanger targeted in the phosphate-absorption study. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: A sodium-handling protein can change how phosphate crosses the gut wall. organism: Human-derived intestinal epithelial system tissue_or_cell_type: Intestinal epithelium; stool and urinary balance experimental_model: Rodent physiology, human enteroid transport and healthy-volunteer intervention limitations: Tenapanor inhibits NHE3 rather than binding phosphate. TEER is an epithelial assay measure, not a direct clinical permeability score. exposure: Enteroid NHE3 perturbation; healthy volunteers 15 mg tenapanor twice daily for four days evidence_span: {"source_cache": "artifacts/phosphorus-research/30158152.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e", "start_char": 0, "end_char": 1701, "text_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e"} [phosphorus-p30158152] Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. (2018). https://pubmed.ncbi.nlm.nih.gov/30158152/ DOI: 10.1126/scitranslmed.aam6474
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Tenapanor reduced paracellular phosphate permeability in the human intestinal enteroid model.

    Tenapanor → Human intestinal enteroid paracellular phosphate flux source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/30158152.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e", "start_char": 0, "end_char": 1701, "text_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e"}
    experimental_model
    Rodent physiology, human enteroid transport and healthy-volunteer intervention
    exposure
    Enteroid NHE3 perturbation; healthy volunteers 15 mg tenapanor twice daily for four days
    limitations
    Tenapanor inhibits NHE3 rather than binding phosphate. TEER is an epithelial assay measure, not a direct clinical permeability score.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Human-derived enteroids
    plain_language
    Less phosphate crossed between the cells.
    primary_references
    [phosphorus-p30158152] Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. (2018). https://pubmed.ncbi.nlm.nih.gov/30158152/ DOI: 10.1126/scitranslmed.aam6474
    tissue_or_cell_type
    Intestinal epithelium; stool and urinary balance

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 347–358

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rodent physiology, human enteroid transport and healthy-volunteer intervention · source_derived_draft · unverified_draft

    ### phosphorus-tenapanor-pi Tenapanor reduced paracellular phosphate permeability in the human intestinal enteroid model. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: Less phosphate crossed between the cells. organism: Human-derived enteroids tissue_or_cell_type: Intestinal epithelium; stool and urinary balance experimental_model: Rodent physiology, human enteroid transport and healthy-volunteer intervention limitations: Tenapanor inhibits NHE3 rather than binding phosphate. TEER is an epithelial assay measure, not a direct clinical permeability score. exposure: Enteroid NHE3 perturbation; healthy volunteers 15 mg tenapanor twice daily for four days evidence_span: {"source_cache": "artifacts/phosphorus-research/30158152.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e", "start_char": 0, "end_char": 1701, "text_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e"} [phosphorus-p30158152] Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. (2018). https://pubmed.ncbi.nlm.nih.gov/30158152/ DOI: 10.1126/scitranslmed.aam6474
    Complete structured claim and evidence

  2. Tenapanor increased transepithelial electrical resistance in the human intestinal enteroid model.

    Tenapanor → Human intestinal enteroid transepithelial electrical resistance source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/30158152.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e", "start_char": 0, "end_char": 1701, "text_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e"}
    experimental_model
    Rodent physiology, human enteroid transport and healthy-volunteer intervention
    exposure
    Enteroid NHE3 perturbation; healthy volunteers 15 mg tenapanor twice daily for four days
    limitations
    Tenapanor inhibits NHE3 rather than binding phosphate. TEER is an epithelial assay measure, not a direct clinical permeability score.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Human-derived enteroids
    plain_language
    The epithelial barrier became less electrically conductive in this assay.
    primary_references
    [phosphorus-p30158152] Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. (2018). https://pubmed.ncbi.nlm.nih.gov/30158152/ DOI: 10.1126/scitranslmed.aam6474
    tissue_or_cell_type
    Intestinal epithelium; stool and urinary balance

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 334–345

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rodent physiology, human enteroid transport and healthy-volunteer intervention · source_derived_draft · unverified_draft

    ### phosphorus-tenapanor-teer Tenapanor increased transepithelial electrical resistance in the human intestinal enteroid model. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The epithelial barrier became less electrically conductive in this assay. organism: Human-derived enteroids tissue_or_cell_type: Intestinal epithelium; stool and urinary balance experimental_model: Rodent physiology, human enteroid transport and healthy-volunteer intervention limitations: Tenapanor inhibits NHE3 rather than binding phosphate. TEER is an epithelial assay measure, not a direct clinical permeability score. exposure: Enteroid NHE3 perturbation; healthy volunteers 15 mg tenapanor twice daily for four days evidence_span: {"source_cache": "artifacts/phosphorus-research/30158152.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e", "start_char": 0, "end_char": 1701, "text_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e"} [phosphorus-p30158152] Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. (2018). https://pubmed.ncbi.nlm.nih.gov/30158152/ DOI: 10.1126/scitranslmed.aam6474
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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