Component
Human intestinal enteroid paracellular phosphate flux
Human intestinal enteroid paracellular phosphate flux. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
NHE3-deficient monolayers mimicked the phosphate phenotype and showed no further tenapanor effect on phosphate flux or TEER.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/phosphorus-research/30158152.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e", "start_char": 0, "end_char": 1701, "text_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e"}
- experimental_model
- Rodent physiology, human enteroid transport and healthy-volunteer intervention
- exposure
- Enteroid NHE3 perturbation; healthy volunteers 15 mg tenapanor twice daily for four days
- limitations
- Tenapanor inhibits NHE3 rather than binding phosphate. TEER is an epithelial assay measure, not a direct clinical permeability score.
- nutrient_topic
- Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
- organism
- Human-derived enteroids
- plain_language
- When the drug’s target was missing, adding the drug no longer changed these measurements.
- primary_references
- [phosphorus-p30158152] Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. (2018). https://pubmed.ncbi.nlm.nih.gov/30158152/ DOI: 10.1126/scitranslmed.aam6474
- tissue_or_cell_type
- Intestinal epithelium; stool and urinary balance
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 360–371
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rodent physiology, human enteroid transport and healthy-volunteer intervention · source_derived_draft · unverified_draft
### phosphorus-nhe3-null NHE3-deficient monolayers mimicked the phosphate phenotype and showed no further tenapanor effect on phosphate flux or TEER. Condition category: machinery_impairment nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: When the drug’s target was missing, adding the drug no longer changed these measurements. organism: Human-derived enteroids tissue_or_cell_type: Intestinal epithelium; stool and urinary balance experimental_model: Rodent physiology, human enteroid transport and healthy-volunteer intervention limitations: Tenapanor inhibits NHE3 rather than binding phosphate. TEER is an epithelial assay measure, not a direct clinical permeability score. exposure: Enteroid NHE3 perturbation; healthy volunteers 15 mg tenapanor twice daily for four days evidence_span: {"source_cache": "artifacts/phosphorus-research/30158152.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e", "start_char": 0, "end_char": 1701, "text_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e"} [phosphorus-p30158152] Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. (2018). https://pubmed.ncbi.nlm.nih.gov/30158152/ DOI: 10.1126/scitranslmed.aam6474
Complete structured claim and evidenceTenapanor reduced paracellular phosphate permeability in the human intestinal enteroid model.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/phosphorus-research/30158152.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e", "start_char": 0, "end_char": 1701, "text_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e"}
- experimental_model
- Rodent physiology, human enteroid transport and healthy-volunteer intervention
- exposure
- Enteroid NHE3 perturbation; healthy volunteers 15 mg tenapanor twice daily for four days
- limitations
- Tenapanor inhibits NHE3 rather than binding phosphate. TEER is an epithelial assay measure, not a direct clinical permeability score.
- nutrient_topic
- Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
- organism
- Human-derived enteroids
- plain_language
- Less phosphate crossed between the cells.
- primary_references
- [phosphorus-p30158152] Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. (2018). https://pubmed.ncbi.nlm.nih.gov/30158152/ DOI: 10.1126/scitranslmed.aam6474
- tissue_or_cell_type
- Intestinal epithelium; stool and urinary balance
Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 347–358
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rodent physiology, human enteroid transport and healthy-volunteer intervention · source_derived_draft · unverified_draft
### phosphorus-tenapanor-pi Tenapanor reduced paracellular phosphate permeability in the human intestinal enteroid model. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: Less phosphate crossed between the cells. organism: Human-derived enteroids tissue_or_cell_type: Intestinal epithelium; stool and urinary balance experimental_model: Rodent physiology, human enteroid transport and healthy-volunteer intervention limitations: Tenapanor inhibits NHE3 rather than binding phosphate. TEER is an epithelial assay measure, not a direct clinical permeability score. exposure: Enteroid NHE3 perturbation; healthy volunteers 15 mg tenapanor twice daily for four days evidence_span: {"source_cache": "artifacts/phosphorus-research/30158152.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e", "start_char": 0, "end_char": 1701, "text_sha256": "6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e"} [phosphorus-p30158152] Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. (2018). https://pubmed.ncbi.nlm.nih.gov/30158152/ DOI: 10.1126/scitranslmed.aam6474
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.