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TEER is an epithelial assay measure, not a direct clinical permeability score.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human-derived enteroids","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Less phosphate crossed between the cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p30158152] Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. (2018). https://pubmed.ncbi.nlm.nih.gov/30158152/ DOI: 10.1126/scitranslmed.aam6474","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal epithelium; stool and urinary balance","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b1310d39-efe0-5cc6-a7e4-654b0c595884","evidence_kind":"source_excerpt","locator":"Lines 347-358","start_line":347,"end_line":358,"excerpt":"### phosphorus-tenapanor-pi\nTenapanor reduced paracellular phosphate permeability in the human intestinal enteroid model.\nCondition category: normal\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Less phosphate crossed between the cells.\norganism: Human-derived enteroids\ntissue_or_cell_type: Intestinal epithelium; stool and urinary balance\nexperimental_model: Rodent physiology, human enteroid transport and healthy-volunteer intervention\nlimitations: Tenapanor inhibits NHE3 rather than binding phosphate. TEER is an epithelial assay measure, not a direct clinical permeability score.\nexposure: Enteroid NHE3 perturbation; healthy volunteers 15 mg tenapanor twice daily for four days\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/30158152.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e\", \"start_char\": 0, \"end_char\": 1701, \"text_sha256\": \"6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e\"}\n[phosphorus-p30158152] Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. 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