Component

SLC5A11 (human SMIT2)

SLC5A11 (human SMIT2). Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Human SMIT2 expression increased D-chiro-inositol uptake 159-fold in rat L6 cells.

    SLC5A11 (human SMIT2) → D-chiro-inositol source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/19032932.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242", "start_char": 0, "end_char": 1164, "text_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242"}
    experimental_model
    Human SMIT2 overexpression and radiotracer uptake
    exposure
    Overexpression, glucose competition and insulin exposure
    limitations
    Overexpression is not normal transporter abundance. Insulin experiments used untransfected rat cells; changes in human diabetes are proposed, not demonstrated here.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Human transporter in rat L6 myoblasts
    plain_language
    The transporter can carry a second inositol stereoisomer.
    primary_references
    [ino-p19032932] Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19032932/ DOI: 10.1016/j.abb.2008.11.008
    tissue_or_cell_type
    Skeletal-muscle cell model
    transport_effect
    raises Expression increased D-chiro-inositol uptake 159-fold.
    transport_pool
    the expressing cell Expression increased D-chiro-inositol uptake 159-fold.

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 301–312

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human SMIT2 overexpression and radiotracer uptake · source_derived_draft · unverified_draft

    ### ino-smit2-dci Human SMIT2 expression increased D-chiro-inositol uptake 159-fold in rat L6 cells. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: The transporter can carry a second inositol stereoisomer. organism: Human transporter in rat L6 myoblasts tissue_or_cell_type: Skeletal-muscle cell model experimental_model: Human SMIT2 overexpression and radiotracer uptake limitations: Overexpression is not normal transporter abundance. Insulin experiments used untransfected rat cells; changes in human diabetes are proposed, not demonstrated here. exposure: Overexpression, glucose competition and insulin exposure evidence_span: {"source_cache": "artifacts/inositol-research/19032932.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242", "start_char": 0, "end_char": 1164, "text_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242"} [ino-p19032932] Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19032932/ DOI: 10.1016/j.abb.2008.11.008
    Complete structured claim and evidence

  2. Human SMIT2 expression increased myo-inositol uptake 37-fold relative to vector control in rat L6 cells.

    SLC5A11 (human SMIT2) → Myo-inositol source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/19032932.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242", "start_char": 0, "end_char": 1164, "text_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242"}
    experimental_model
    Human SMIT2 overexpression and radiotracer uptake
    exposure
    Overexpression, glucose competition and insulin exposure
    limitations
    Overexpression is not normal transporter abundance. Insulin experiments used untransfected rat cells; changes in human diabetes are proposed, not demonstrated here.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Human transporter in rat L6 myoblasts
    plain_language
    SMIT2 can bring free myo-inositol into cells.
    primary_references
    [ino-p19032932] Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19032932/ DOI: 10.1016/j.abb.2008.11.008
    tissue_or_cell_type
    Skeletal-muscle cell model
    transport_effect
    raises Expression increased myo-inositol uptake 37-fold against vector control.
    transport_pool
    the expressing cell Expression increased myo-inositol uptake 37-fold against vector control.

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 288–299

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human SMIT2 overexpression and radiotracer uptake · source_derived_draft · unverified_draft

    ### ino-smit2-myo Human SMIT2 expression increased myo-inositol uptake 37-fold relative to vector control in rat L6 cells. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: SMIT2 can bring free myo-inositol into cells. organism: Human transporter in rat L6 myoblasts tissue_or_cell_type: Skeletal-muscle cell model experimental_model: Human SMIT2 overexpression and radiotracer uptake limitations: Overexpression is not normal transporter abundance. Insulin experiments used untransfected rat cells; changes in human diabetes are proposed, not demonstrated here. exposure: Overexpression, glucose competition and insulin exposure evidence_span: {"source_cache": "artifacts/inositol-research/19032932.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242", "start_char": 0, "end_char": 1164, "text_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242"} [ino-p19032932] Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19032932/ DOI: 10.1016/j.abb.2008.11.008
    Complete structured claim and evidence

What acts on it

  1. A fitted five-state model of human SMIT2 currents included cooperative Na+ binding and a likely rate-limiting return of empty transporter.

    Sodium ion → SLC5A11 (human SMIT2) source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/24944204.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "12216ce12672706d91e22c9fbc1ebc5dbe77444e9869048f8a0d456f621cb41e", "start_char": 0, "end_char": 1647, "text_sha256": "12216ce12672706d91e22c9fbc1ebc5dbe77444e9869048f8a0d456f621cb41e"}
    experimental_model
    Voltage clamp and kinetic model fitting
    exposure
    Sodium and voltage manipulations
    limitations
    Cooperative sodium binding and turnover were model-derived; this is not a clinical sodium recommendation.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Human SMIT2 in Xenopus oocytes
    plain_language
    The sodium gradient is part of the transport machinery, rather than inositol moving independently of ions.
    primary_references
    [ino-p24944204] The transport mechanism of the human sodium/myo-inositol transporter 2 (SMIT2/SGLT6), a member of the LeuT structural family. (2014). https://pubmed.ncbi.nlm.nih.gov/24944204/ DOI: 10.1152/ajpcell.00054.2014
    tissue_or_cell_type
    Heterologous membrane transport

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 340–351

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Voltage clamp and kinetic model fitting · source_derived_draft · unverified_draft

    ### ino-smit2-sodium A fitted five-state model of human SMIT2 currents included cooperative Na+ binding and a likely rate-limiting return of empty transporter. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: The sodium gradient is part of the transport machinery, rather than inositol moving independently of ions. organism: Human SMIT2 in Xenopus oocytes tissue_or_cell_type: Heterologous membrane transport experimental_model: Voltage clamp and kinetic model fitting limitations: Cooperative sodium binding and turnover were model-derived; this is not a clinical sodium recommendation. exposure: Sodium and voltage manipulations evidence_span: {"source_cache": "artifacts/inositol-research/24944204.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "12216ce12672706d91e22c9fbc1ebc5dbe77444e9869048f8a0d456f621cb41e", "start_char": 0, "end_char": 1647, "text_sha256": "12216ce12672706d91e22c9fbc1ebc5dbe77444e9869048f8a0d456f621cb41e"} [ino-p24944204] The transport mechanism of the human sodium/myo-inositol transporter 2 (SMIT2/SGLT6), a member of the LeuT structural family. (2014). https://pubmed.ncbi.nlm.nih.gov/24944204/ DOI: 10.1152/ajpcell.00054.2014
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Glucose competed for D-chiro-inositol uptake with a reported Ki of 6.1 mM in the SMIT2 expression system, without evidence that SMIT2 transported glucose in those assays.

    D-glucose → D-chiro-inositol uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/19032932.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242", "start_char": 0, "end_char": 1164, "text_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242"}
    experimental_model
    Human SMIT2 overexpression and radiotracer uptake
    exposure
    Overexpression, glucose competition and insulin exposure
    limitations
    Overexpression is not normal transporter abundance. Insulin experiments used untransfected rat cells; changes in human diabetes are proposed, not demonstrated here.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Human transporter in rat L6 myoblasts
    plain_language
    Glucose competed for entry without itself becoming demonstrated cargo of this transporter.
    primary_references
    [ino-p19032932] Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19032932/ DOI: 10.1016/j.abb.2008.11.008
    tissue_or_cell_type
    Skeletal-muscle cell model

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 314–325

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human SMIT2 overexpression and radiotracer uptake · source_derived_draft · unverified_draft

    ### ino-smit2-glucose Glucose competed for D-chiro-inositol uptake with a reported Ki of 6.1 mM in the SMIT2 expression system, without evidence that SMIT2 transported glucose in those assays. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: Glucose competed for entry without itself becoming demonstrated cargo of this transporter. organism: Human transporter in rat L6 myoblasts tissue_or_cell_type: Skeletal-muscle cell model experimental_model: Human SMIT2 overexpression and radiotracer uptake limitations: Overexpression is not normal transporter abundance. Insulin experiments used untransfected rat cells; changes in human diabetes are proposed, not demonstrated here. exposure: Overexpression, glucose competition and insulin exposure evidence_span: {"source_cache": "artifacts/inositol-research/19032932.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242", "start_char": 0, "end_char": 1164, "text_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242"} [ino-p19032932] Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19032932/ DOI: 10.1016/j.abb.2008.11.008
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards