Component

D-chiro-inositol uptake

D-chiro-inositol uptake. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. More than 98% of dietary D-chiro-inositol equivalents from the tested rodent diet, purified pinitol or labeled D-chiro-inositol were absorbed in rat balance experiments.

    D-chiro-inositol → D-chiro-inositol uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/19586572.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7c6e57e631fef5921afd04f75718024d5b14ca525460e2c96275a4fc320c3b26", "start_char": 0, "end_char": 1544, "text_sha256": "7c6e57e631fef5921afd04f75718024d5b14ca525460e2c96275a4fc320c3b26"}
    experimental_model
    Dietary balance, GC-MS and stable-isotope tracing
    exposure
    Defined diets, heavy water and deuterated myo-inositol/DCI
    limitations
    Failure to detect conversion in mice does not exclude all human or isolated-tissue activity. Isotope strategy, chemical identification, species and dietary DCI contamination may contribute to disagreement with earlier radiotracer reports.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Rats and mice; conversion tracing in mice
    plain_language
    Diet itself can supply substantial D-chiro-inositol and confound attempts to measure its synthesis.
    primary_references
    [ino-p19586572] d- chiro-Inositol is absorbed but not synthesised in rodents. (2009). https://pubmed.ncbi.nlm.nih.gov/19586572/ DOI: 10.1017/s0007114509990456
    tissue_or_cell_type
    Gastrointestinal absorption, plasma and excreta

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 1237–1248

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dietary balance, GC-MS and stable-isotope tracing · source_derived_draft · unverified_draft

    ### ino-dci-absorption More than 98% of dietary D-chiro-inositol equivalents from the tested rodent diet, purified pinitol or labeled D-chiro-inositol were absorbed in rat balance experiments. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: Diet itself can supply substantial D-chiro-inositol and confound attempts to measure its synthesis. organism: Rats and mice; conversion tracing in mice tissue_or_cell_type: Gastrointestinal absorption, plasma and excreta experimental_model: Dietary balance, GC-MS and stable-isotope tracing limitations: Failure to detect conversion in mice does not exclude all human or isolated-tissue activity. Isotope strategy, chemical identification, species and dietary DCI contamination may contribute to disagreement with earlier radiotracer reports. exposure: Defined diets, heavy water and deuterated myo-inositol/DCI evidence_span: {"source_cache": "artifacts/inositol-research/19586572.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7c6e57e631fef5921afd04f75718024d5b14ca525460e2c96275a4fc320c3b26", "start_char": 0, "end_char": 1544, "text_sha256": "7c6e57e631fef5921afd04f75718024d5b14ca525460e2c96275a4fc320c3b26"} [ino-p19586572] d- chiro-Inositol is absorbed but not synthesised in rodents. (2009). https://pubmed.ncbi.nlm.nih.gov/19586572/ DOI: 10.1017/s0007114509990456
    Complete structured claim and evidence

  2. Insulin exposure at 2 micromolar for 24 hours increased specific D-chiro-inositol uptake 18-fold in untransfected rat L6 cells.

    Insulin → D-chiro-inositol uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/19032932.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242", "start_char": 0, "end_char": 1164, "text_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242"}
    experimental_model
    Human SMIT2 overexpression and radiotracer uptake
    exposure
    Overexpression, glucose competition and insulin exposure
    limitations
    Overexpression is not normal transporter abundance. Insulin experiments used untransfected rat cells; changes in human diabetes are proposed, not demonstrated here.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Human transporter in rat L6 myoblasts
    plain_language
    The muscle-cell model adjusted its inositol uptake after insulin exposure.
    primary_references
    [ino-p19032932] Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19032932/ DOI: 10.1016/j.abb.2008.11.008
    tissue_or_cell_type
    Skeletal-muscle cell model

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 327–338

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human SMIT2 overexpression and radiotracer uptake · source_derived_draft · unverified_draft

    ### ino-insulin-dci-uptake Insulin exposure at 2 micromolar for 24 hours increased specific D-chiro-inositol uptake 18-fold in untransfected rat L6 cells. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: The muscle-cell model adjusted its inositol uptake after insulin exposure. organism: Human transporter in rat L6 myoblasts tissue_or_cell_type: Skeletal-muscle cell model experimental_model: Human SMIT2 overexpression and radiotracer uptake limitations: Overexpression is not normal transporter abundance. Insulin experiments used untransfected rat cells; changes in human diabetes are proposed, not demonstrated here. exposure: Overexpression, glucose competition and insulin exposure evidence_span: {"source_cache": "artifacts/inositol-research/19032932.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242", "start_char": 0, "end_char": 1164, "text_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242"} [ino-p19032932] Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19032932/ DOI: 10.1016/j.abb.2008.11.008
    Complete structured claim and evidence

  3. Glucose competed for D-chiro-inositol uptake with a reported Ki of 6.1 mM in the SMIT2 expression system, without evidence that SMIT2 transported glucose in those assays.

    D-glucose → D-chiro-inositol uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/19032932.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242", "start_char": 0, "end_char": 1164, "text_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242"}
    experimental_model
    Human SMIT2 overexpression and radiotracer uptake
    exposure
    Overexpression, glucose competition and insulin exposure
    limitations
    Overexpression is not normal transporter abundance. Insulin experiments used untransfected rat cells; changes in human diabetes are proposed, not demonstrated here.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Human transporter in rat L6 myoblasts
    plain_language
    Glucose competed for entry without itself becoming demonstrated cargo of this transporter.
    primary_references
    [ino-p19032932] Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19032932/ DOI: 10.1016/j.abb.2008.11.008
    tissue_or_cell_type
    Skeletal-muscle cell model

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 314–325

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human SMIT2 overexpression and radiotracer uptake · source_derived_draft · unverified_draft

    ### ino-smit2-glucose Glucose competed for D-chiro-inositol uptake with a reported Ki of 6.1 mM in the SMIT2 expression system, without evidence that SMIT2 transported glucose in those assays. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: Glucose competed for entry without itself becoming demonstrated cargo of this transporter. organism: Human transporter in rat L6 myoblasts tissue_or_cell_type: Skeletal-muscle cell model experimental_model: Human SMIT2 overexpression and radiotracer uptake limitations: Overexpression is not normal transporter abundance. Insulin experiments used untransfected rat cells; changes in human diabetes are proposed, not demonstrated here. exposure: Overexpression, glucose competition and insulin exposure evidence_span: {"source_cache": "artifacts/inositol-research/19032932.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242", "start_char": 0, "end_char": 1164, "text_sha256": "4fdc565b9aa26ef5f2d083c539a1b0367403b39f0c75d3ea1b194bf6fa525242"} [ino-p19032932] Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19032932/ DOI: 10.1016/j.abb.2008.11.008
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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