{"id":"48b05904-7682-51c9-8db4-f6b7ea3ec676","stable_key":"e69ef6a0-0e23-5eac-aca1-cf333781b962:ino-dci-absorption","predicate":"undergoes","statement":"More than 98% of dietary D-chiro-inositol equivalents from the tested rodent diet, purified pinitol or labeled D-chiro-inositol were absorbed in rat balance experiments.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"8e707c3c-ef85-5582-a044-8050968dee71","mechanism_event_label":"Diet itself can supply substantial D-chiro-inositol and confound attempts to measure its synthesis.","subject":{"id":"b687b65c-726f-551a-846b-fc488629669c","slug":"d-chiro-inositol","display_name":"D-chiro-inositol","entity_type_key":"small_molecule"},"object":{"id":"80a5a753-57c3-5394-b464-e67f1347af53","slug":"dci-uptake","display_name":"D-chiro-inositol uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8e707c3c-ef85-5582-a044-8050968dee71","stable_key":"e69ef6a0-0e23-5eac-aca1-cf333781b962:ino-dci-absorption-event","event_type":"observed_intervention","label":"Diet itself can supply substantial D-chiro-inositol and confound attempts to measure its synthesis.","description":"More than 98% of dietary D-chiro-inositol equivalents from the tested rodent diet, purified pinitol or labeled D-chiro-inositol were absorbed in rat balance experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"07337bf8-145e-5780-97b6-09591b18f294","slug":"pinitol","display_name":"D-pinitol","entity_type_key":"small_molecule"},"role":"tested_dietary_form","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b687b65c-726f-551a-846b-fc488629669c","slug":"d-chiro-inositol","display_name":"D-chiro-inositol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"80a5a753-57c3-5394-b464-e67f1347af53","slug":"dci-uptake","display_name":"D-chiro-inositol uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/inositol-research/19586572.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7c6e57e631fef5921afd04f75718024d5b14ca525460e2c96275a4fc320c3b26\", \"start_char\": 0, \"end_char\": 1544, \"text_sha256\": \"7c6e57e631fef5921afd04f75718024d5b14ca525460e2c96275a4fc320c3b26\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dietary balance, GC-MS and stable-isotope tracing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Defined diets, heavy water and deuterated myo-inositol/DCI","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Failure to detect conversion in mice does not exclude all human or isolated-tissue activity. Isotope strategy, chemical identification, species and dietary DCI contamination may contribute to disagreement with earlier radiotracer reports.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Inositol research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"inositol","display_name":"Inositol (stereoisomer family)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Rats and mice; conversion tracing in mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Diet itself can supply substantial D-chiro-inositol and confound attempts to measure its synthesis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ino-p19586572] d- chiro-Inositol is absorbed but not synthesised in rodents. (2009). https://pubmed.ncbi.nlm.nih.gov/19586572/ DOI: 10.1017/s0007114509990456","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Gastrointestinal absorption, plasma and excreta","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"88388dcc-0088-5770-898f-41d73b2513e9","evidence_kind":"source_excerpt","locator":"Lines 1237-1248","start_line":1237,"end_line":1248,"excerpt":"### ino-dci-absorption\nMore than 98% of dietary D-chiro-inositol equivalents from the tested rodent diet, purified pinitol or labeled D-chiro-inositol were absorbed in rat balance experiments.\nCondition category: normal\nnutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Diet itself can supply substantial D-chiro-inositol and confound attempts to measure its synthesis.\norganism: Rats and mice; conversion tracing in mice\ntissue_or_cell_type: Gastrointestinal absorption, plasma and excreta\nexperimental_model: Dietary balance, GC-MS and stable-isotope tracing\nlimitations: Failure to detect conversion in mice does not exclude all human or isolated-tissue activity. Isotope strategy, chemical identification, species and dietary DCI contamination may contribute to disagreement with earlier radiotracer reports.\nexposure: Defined diets, heavy water and deuterated myo-inositol/DCI\nevidence_span: {\"source_cache\": \"artifacts/inositol-research/19586572.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7c6e57e631fef5921afd04f75718024d5b14ca525460e2c96275a4fc320c3b26\", \"start_char\": 0, \"end_char\": 1544, \"text_sha256\": \"7c6e57e631fef5921afd04f75718024d5b14ca525460e2c96275a4fc320c3b26\"}\n[ino-p19586572] d- chiro-Inositol is absorbed but not synthesised in rodents. (2009). https://pubmed.ncbi.nlm.nih.gov/19586572/ DOI: 10.1017/s0007114509990456","model_system":"Dietary balance, GC-MS and stable-isotope tracing","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ino-p19586572] d- chiro-Inositol is absorbed but not synthesised in rodents. (2009). https://pubmed.ncbi.nlm.nih.gov/19586572/ DOI: 10.1017/s0007114509990456","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d590c659-b774-50e6-9f1d-aff61d5f7c9c","stable_key":"import-e69ef6a0-0e23-5eac-aca1-cf333781b962","title":"Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f7adbcedad647d5f8a3cc9e46bfa515e83c508be9c2a4e9d59c5f5dfb0667d53","revision_id":"a82d187c-60fb-52d1-8482-eadb92860f33","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}