Component

Human glucose-6-phosphate transporter / SLC37A4

Human glucose-6-phosphate transporter / SLC37A4. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. SLC37A4 exchanges cytosolic glucose-6-phosphate for luminal inorganic phosphate.

    Human glucose-6-phosphate transporter / SLC37A4 → Glucose-6-phosphate import into the endoplasmic reticulum source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chlorogenic_acid-research/42520004.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6", "start_char": 0, "end_char": 2009, "text_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6"}
    experimental_model
    Cryo-EM with biochemical transport and thermostability assays
    exposure
    Apo, glucose-6-phosphate-bound and chlorogenic-acid-bound structures
    limitations
    Direct structural target evidence does not establish inhibition after ordinary food intake. Variant disease and compound exposure are different mechanisms; coffee does not thereby cause glycogen storage disease.
    nutrient_topic
    Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
    organism
    Human recombinant SLC37A4
    plain_language
    The transporter delivers substrate into the endoplasmic reticulum.
    primary_references
    [chlorogenic_acid-p42520004] Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4. (2026). https://pubmed.ncbi.nlm.nih.gov/42520004/ DOI: 10.1371/journal.pbio.3003833
    tissue_or_cell_type
    HEK293-expressed transporter; purified membrane-protein preparation

    Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 334–345

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cryo-EM with biochemical transport and thermostability assays · source_derived_draft · unverified_draft

    ### chlorogenic_acid-g6p-import SLC37A4 exchanges cytosolic glucose-6-phosphate for luminal inorganic phosphate. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The transporter delivers substrate into the endoplasmic reticulum. organism: Human recombinant SLC37A4 tissue_or_cell_type: HEK293-expressed transporter; purified membrane-protein preparation experimental_model: Cryo-EM with biochemical transport and thermostability assays limitations: Direct structural target evidence does not establish inhibition after ordinary food intake. Variant disease and compound exposure are different mechanisms; coffee does not thereby cause glycogen storage disease. exposure: Apo, glucose-6-phosphate-bound and chlorogenic-acid-bound structures evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/42520004.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6", "start_char": 0, "end_char": 2009, "text_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6"} [chlorogenic_acid-p42520004] Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4. (2026). https://pubmed.ncbi.nlm.nih.gov/42520004/ DOI: 10.1371/journal.pbio.3003833
    Complete structured claim and evidence

What acts on it

  1. Cryo-EM resolved chlorogenic acid at a cytosolic site in inward-facing human SLC37A4.

    Chlorogenic acid / 5-O-caffeoylquinic acid → Human glucose-6-phosphate transporter / SLC37A4 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chlorogenic_acid-research/42520004.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6", "start_char": 0, "end_char": 2009, "text_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6"}
    experimental_model
    Cryo-EM with biochemical transport and thermostability assays
    exposure
    Apo, glucose-6-phosphate-bound and chlorogenic-acid-bound structures
    limitations
    Direct structural target evidence does not establish inhibition after ordinary food intake. Variant disease and compound exposure are different mechanisms; coffee does not thereby cause glycogen storage disease.
    nutrient_topic
    Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
    organism
    Human recombinant SLC37A4
    plain_language
    This is a measured protein complex, not only a docking prediction.
    primary_references
    [chlorogenic_acid-p42520004] Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4. (2026). https://pubmed.ncbi.nlm.nih.gov/42520004/ DOI: 10.1371/journal.pbio.3003833
    tissue_or_cell_type
    HEK293-expressed transporter; purified membrane-protein preparation

    Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 347–358

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cryo-EM with biochemical transport and thermostability assays · source_derived_draft · unverified_draft

    ### chlorogenic_acid-slc37a4-binding Cryo-EM resolved chlorogenic acid at a cytosolic site in inward-facing human SLC37A4. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: This is a measured protein complex, not only a docking prediction. organism: Human recombinant SLC37A4 tissue_or_cell_type: HEK293-expressed transporter; purified membrane-protein preparation experimental_model: Cryo-EM with biochemical transport and thermostability assays limitations: Direct structural target evidence does not establish inhibition after ordinary food intake. Variant disease and compound exposure are different mechanisms; coffee does not thereby cause glycogen storage disease. exposure: Apo, glucose-6-phosphate-bound and chlorogenic-acid-bound structures evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/42520004.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6", "start_char": 0, "end_char": 2009, "text_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6"} [chlorogenic_acid-p42520004] Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4. (2026). https://pubmed.ncbi.nlm.nih.gov/42520004/ DOI: 10.1371/journal.pbio.3003833
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Loss-of-function SLC37A4 variants impair the transport machinery associated with glycogen storage disease Ib.

    Human SLC37A4 loss-of-function variants → Glucose-6-phosphate import into the endoplasmic reticulum source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/chlorogenic_acid-research/42520004.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6", "start_char": 0, "end_char": 2009, "text_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6"}
    experimental_model
    Cryo-EM with biochemical transport and thermostability assays
    exposure
    Apo, glucose-6-phosphate-bound and chlorogenic-acid-bound structures
    limitations
    Direct structural target evidence does not establish inhibition after ordinary food intake. Variant disease and compound exposure are different mechanisms; coffee does not thereby cause glycogen storage disease.
    nutrient_topic
    Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
    organism
    Human recombinant SLC37A4
    plain_language
    The same protein has a normal role and a distinct genetic failure state.
    primary_references
    [chlorogenic_acid-p42520004] Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4. (2026). https://pubmed.ncbi.nlm.nih.gov/42520004/ DOI: 10.1371/journal.pbio.3003833
    tissue_or_cell_type
    HEK293-expressed transporter; purified membrane-protein preparation
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 373–384

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cryo-EM with biochemical transport and thermostability assays · source_derived_draft · unverified_draft

    ### chlorogenic_acid-slc37a4-loss Loss-of-function SLC37A4 variants impair the transport machinery associated with glycogen storage disease Ib. Condition category: machinery_impairment nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same protein has a normal role and a distinct genetic failure state. organism: Human recombinant SLC37A4 tissue_or_cell_type: HEK293-expressed transporter; purified membrane-protein preparation experimental_model: Cryo-EM with biochemical transport and thermostability assays limitations: Direct structural target evidence does not establish inhibition after ordinary food intake. Variant disease and compound exposure are different mechanisms; coffee does not thereby cause glycogen storage disease. exposure: Apo, glucose-6-phosphate-bound and chlorogenic-acid-bound structures evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/42520004.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6", "start_char": 0, "end_char": 2009, "text_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6"} [chlorogenic_acid-p42520004] Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4. (2026). https://pubmed.ncbi.nlm.nih.gov/42520004/ DOI: 10.1371/journal.pbio.3003833
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards