Component
Human SLC37A4 loss-of-function variants
Human SLC37A4 loss-of-function variants. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Loss-of-function SLC37A4 variants impair the transport machinery associated with glycogen storage disease Ib.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/chlorogenic_acid-research/42520004.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6", "start_char": 0, "end_char": 2009, "text_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6"}
- experimental_model
- Cryo-EM with biochemical transport and thermostability assays
- exposure
- Apo, glucose-6-phosphate-bound and chlorogenic-acid-bound structures
- limitations
- Direct structural target evidence does not establish inhibition after ordinary food intake. Variant disease and compound exposure are different mechanisms; coffee does not thereby cause glycogen storage disease.
- nutrient_topic
- Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
- organism
- Human recombinant SLC37A4
- plain_language
- The same protein has a normal role and a distinct genetic failure state.
- primary_references
- [chlorogenic_acid-p42520004] Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4. (2026). https://pubmed.ncbi.nlm.nih.gov/42520004/ DOI: 10.1371/journal.pbio.3003833
- tissue_or_cell_type
- HEK293-expressed transporter; purified membrane-protein preparation
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 373–384
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cryo-EM with biochemical transport and thermostability assays · source_derived_draft · unverified_draft
### chlorogenic_acid-slc37a4-loss Loss-of-function SLC37A4 variants impair the transport machinery associated with glycogen storage disease Ib. Condition category: machinery_impairment nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same protein has a normal role and a distinct genetic failure state. organism: Human recombinant SLC37A4 tissue_or_cell_type: HEK293-expressed transporter; purified membrane-protein preparation experimental_model: Cryo-EM with biochemical transport and thermostability assays limitations: Direct structural target evidence does not establish inhibition after ordinary food intake. Variant disease and compound exposure are different mechanisms; coffee does not thereby cause glycogen storage disease. exposure: Apo, glucose-6-phosphate-bound and chlorogenic-acid-bound structures evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/42520004.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6", "start_char": 0, "end_char": 2009, "text_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6"} [chlorogenic_acid-p42520004] Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4. (2026). https://pubmed.ncbi.nlm.nih.gov/42520004/ DOI: 10.1371/journal.pbio.3003833
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.