Glucose-6-phosphate import into the endoplasmic reticulum: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

SLC37A4 exchanges cytosolic glucose-6-phosphate for luminal inorganic phosphate.
Human glucose-6-phosphate transporter / SLC37A4 → Glucose-6-phosphate import into the endoplasmic reticulum source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/chlorogenic_acid-research/42520004.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6", "start_char": 0, "end_char": 2009, "text_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6"}
experimental_model
Cryo-EM with biochemical transport and thermostability assays
exposure
Apo, glucose-6-phosphate-bound and chlorogenic-acid-bound structures
limitations
Direct structural target evidence does not establish inhibition after ordinary food intake. Variant disease and compound exposure are different mechanisms; coffee does not thereby cause glycogen storage disease.
nutrient_topic
Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
organism
Human recombinant SLC37A4
plain_language
The transporter delivers substrate into the endoplasmic reticulum.
primary_references
[chlorogenic_acid-p42520004] Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4. (2026). https://pubmed.ncbi.nlm.nih.gov/42520004/ DOI: 10.1371/journal.pbio.3003833
tissue_or_cell_type
HEK293-expressed transporter; purified membrane-protein preparation
Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 334–345
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cryo-EM with biochemical transport and thermostability assays · source_derived_draft · unverified_draft
### chlorogenic_acid-g6p-import SLC37A4 exchanges cytosolic glucose-6-phosphate for luminal inorganic phosphate. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The transporter delivers substrate into the endoplasmic reticulum. organism: Human recombinant SLC37A4 tissue_or_cell_type: HEK293-expressed transporter; purified membrane-protein preparation experimental_model: Cryo-EM with biochemical transport and thermostability assays limitations: Direct structural target evidence does not establish inhibition after ordinary food intake. Variant disease and compound exposure are different mechanisms; coffee does not thereby cause glycogen storage disease. exposure: Apo, glucose-6-phosphate-bound and chlorogenic-acid-bound structures evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/42520004.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6", "start_char": 0, "end_char": 2009, "text_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6"} [chlorogenic_acid-p42520004] Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4. (2026). https://pubmed.ncbi.nlm.nih.gov/42520004/ DOI: 10.1371/journal.pbio.3003833
Complete structured claim and evidence
Loss-of-function SLC37A4 variants impair the transport machinery associated with glycogen storage disease Ib.
Human SLC37A4 loss-of-function variants → Glucose-6-phosphate import into the endoplasmic reticulum source_derived_draftungraded
Experimental context and source evidence
availability_state
machinery_impairment Imported condition classification; unverified.
evidence_span
{"source_cache": "artifacts/chlorogenic_acid-research/42520004.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6", "start_char": 0, "end_char": 2009, "text_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6"}
experimental_model
Cryo-EM with biochemical transport and thermostability assays
exposure
Apo, glucose-6-phosphate-bound and chlorogenic-acid-bound structures
limitations
Direct structural target evidence does not establish inhibition after ordinary food intake. Variant disease and compound exposure are different mechanisms; coffee does not thereby cause glycogen storage disease.
nutrient_topic
Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
organism
Human recombinant SLC37A4
plain_language
The same protein has a normal role and a distinct genetic failure state.
primary_references
[chlorogenic_acid-p42520004] Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4. (2026). https://pubmed.ncbi.nlm.nih.gov/42520004/ DOI: 10.1371/journal.pbio.3003833
tissue_or_cell_type
HEK293-expressed transporter; purified membrane-protein preparation
trigger_kind
machinery_impairment Imported condition classification; unverified.
Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 373–384
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cryo-EM with biochemical transport and thermostability assays · source_derived_draft · unverified_draft
### chlorogenic_acid-slc37a4-loss Loss-of-function SLC37A4 variants impair the transport machinery associated with glycogen storage disease Ib. Condition category: machinery_impairment nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same protein has a normal role and a distinct genetic failure state. organism: Human recombinant SLC37A4 tissue_or_cell_type: HEK293-expressed transporter; purified membrane-protein preparation experimental_model: Cryo-EM with biochemical transport and thermostability assays limitations: Direct structural target evidence does not establish inhibition after ordinary food intake. Variant disease and compound exposure are different mechanisms; coffee does not thereby cause glycogen storage disease. exposure: Apo, glucose-6-phosphate-bound and chlorogenic-acid-bound structures evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/42520004.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6", "start_char": 0, "end_char": 2009, "text_sha256": "c05de010432b8bfaee87bdbba5f9fe93e7a262d41a17d19ec6e0b7b480e35ee6"} [chlorogenic_acid-p42520004] Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4. (2026). https://pubmed.ncbi.nlm.nih.gov/42520004/ DOI: 10.1371/journal.pbio.3003833
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Glucose-6-phosphate import into the endoplasmic reticulum