Component

Shivering thermogenesis

Shivering thermogenesis. Species, exposure and limitations are retained in each linked claim.

7 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Cold exposure increased circulating irisin and FGF21, with irisin secretion induced in proportion to shivering intensity and of similar magnitude to exercise-stimulated secretion.

    Shivering thermogenesis → Circulating irisin concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/cold-research/24506871.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "980c2630ed13bf2a55f813a6df483edb68a1d6370c0f1afdfcbc7df7817eb610", "start_char": 0, "end_char": 1149, "text_sha256": "980c2630ed13bf2a55f813a6df483edb68a1d6370c0f1afdfcbc7df7817eb610"}
    experimental_model
    Human cold exposure with circulating myokine measurement and human adipocyte treatment
    exposure
    Cold exposure sufficient to induce shivering; FNDC5 and FGF21 treatment of human adipocytes
    limitations
    The proportionality to shivering intensity is the mechanistic link. Depot-specific adipocyte responses mean this is not a uniform browning effect.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Human
    plain_language
    Shivering muscle releases the same messenger exercising muscle does, in proportion to how hard it shivers.
    primary_references
    [cold-p24506871] Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. (2014). https://pubmed.ncbi.nlm.nih.gov/24506871/ DOI: 10.1016/j.cmet.2013.12.017
    tissue_or_cell_type
    Skeletal muscle and adipose tissue

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 481–492

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human cold exposure with circulating myokine measurement and human adipocyte treatment · source_derived_draft · unverified_draft

    ### cold-irisin-shivering Cold exposure increased circulating irisin and FGF21, with irisin secretion induced in proportion to shivering intensity and of similar magnitude to exercise-stimulated secretion. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Shivering muscle releases the same messenger exercising muscle does, in proportion to how hard it shivers. organism: Human tissue_or_cell_type: Skeletal muscle and adipose tissue experimental_model: Human cold exposure with circulating myokine measurement and human adipocyte treatment limitations: The proportionality to shivering intensity is the mechanistic link. Depot-specific adipocyte responses mean this is not a uniform browning effect. exposure: Cold exposure sufficient to induce shivering; FNDC5 and FGF21 treatment of human adipocytes evidence_span: {"source_cache": "artifacts/cold-research/24506871.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "980c2630ed13bf2a55f813a6df483edb68a1d6370c0f1afdfcbc7df7817eb610", "start_char": 0, "end_char": 1149, "text_sha256": "980c2630ed13bf2a55f813a6df483edb68a1d6370c0f1afdfcbc7df7817eb610"} [cold-p24506871] Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. (2014). https://pubmed.ncbi.nlm.nih.gov/24506871/ DOI: 10.1016/j.cmet.2013.12.017
    Complete structured claim and evidence

What acts on it

  1. An inverse relationship was found between brown adipose tissue activity and shivering, and brown adipose tissue radio density increased upon cold exposure, indicating reduced triglyceride content.

    Brown adipose tissue oxidative metabolism → Shivering thermogenesis source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/cold-research/22269323.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "74713401a7fdc40f7921b595ecc554999d10e2406589f231fc68bf0ae460812f", "start_char": 0, "end_char": 1306, "text_sha256": "74713401a7fdc40f7921b595ecc554999d10e2406589f231fc68bf0ae460812f"}
    experimental_model
    Six healthy men studied with 11C-acetate, 18FDG and a fatty acid tracer under controlled cold
    exposure
    Controlled cold exposure with quantified oxidative metabolism and substrate turnover
    limitations
    The acetate tracer measures oxidative metabolism rather than glucose uptake alone, which is what makes the thermogenic claim interpretable. Six subjects is a small sample.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Human
    plain_language
    The more this tissue works, the less you shiver, and it visibly uses up its own fat.
    primary_references
    [cold-p22269323] Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. (2012). https://pubmed.ncbi.nlm.nih.gov/22269323/ DOI: 10.1172/jci60433
    tissue_or_cell_type
    Brown adipose tissue, skeletal muscle and subcutaneous fat

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 286–297

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Six healthy men studied with 11C-acetate, 18FDG and a fatty acid tracer under controlled cold · source_derived_draft · unverified_draft

    ### cold-bat-shivering-inverse An inverse relationship was found between brown adipose tissue activity and shivering, and brown adipose tissue radio density increased upon cold exposure, indicating reduced triglyceride content. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The more this tissue works, the less you shiver, and it visibly uses up its own fat. organism: Human tissue_or_cell_type: Brown adipose tissue, skeletal muscle and subcutaneous fat experimental_model: Six healthy men studied with 11C-acetate, 18FDG and a fatty acid tracer under controlled cold limitations: The acetate tracer measures oxidative metabolism rather than glucose uptake alone, which is what makes the thermogenic claim interpretable. Six subjects is a small sample. exposure: Controlled cold exposure with quantified oxidative metabolism and substrate turnover evidence_span: {"source_cache": "artifacts/cold-research/22269323.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "74713401a7fdc40f7921b595ecc554999d10e2406589f231fc68bf0ae460812f", "start_char": 0, "end_char": 1306, "text_sha256": "74713401a7fdc40f7921b595ecc554999d10e2406589f231fc68bf0ae460812f"} [cold-p22269323] Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. (2012). https://pubmed.ncbi.nlm.nih.gov/22269323/ DOI: 10.1172/jci60433
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Brown adipose volume correlated with the change in metabolic heat production during the mild cold phase, and positively correlated with rectal temperature at the end of that phase, which in turn correlated with shivering onset time.

    Detectable brown adipose tissue volume → Non-shivering thermogenesis source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/cold-research/32948898.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "699fc07665c5f8800951348b6948dba539ed6aed5d1d354d4793be8f9f731b6a", "start_char": 0, "end_char": 1697, "text_sha256": "699fc07665c5f8800951348b6948dba539ed6aed5d1d354d4793be8f9f731b6a"}
    experimental_model
    Eighteen men with measured brown adipose volume during gradual cold exposure
    exposure
    Gradual cooling to 18.6 degrees C for non-shivering thermogenesis and 11.6 degrees C for shivering onset
    limitations
    Correlational human physiology. It tests whether muscle compensates for low brown fat, and finds an earlier shivering onset instead.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Human
    plain_language
    People with more of the tissue made more heat without shivering and started shivering later.
    primary_references
    [cold-p32948898] Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans. (2020). https://pubmed.ncbi.nlm.nih.gov/32948898/ DOI: 10.1007/s00421-020-04496-1
    tissue_or_cell_type
    Brown adipose tissue and skeletal muscle

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 507–518

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Eighteen men with measured brown adipose volume during gradual cold exposure · source_derived_draft · unverified_draft

    ### cold-bat-volume-nst Brown adipose volume correlated with the change in metabolic heat production during the mild cold phase, and positively correlated with rectal temperature at the end of that phase, which in turn correlated with shivering onset time. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: People with more of the tissue made more heat without shivering and started shivering later. organism: Human tissue_or_cell_type: Brown adipose tissue and skeletal muscle experimental_model: Eighteen men with measured brown adipose volume during gradual cold exposure limitations: Correlational human physiology. It tests whether muscle compensates for low brown fat, and finds an earlier shivering onset instead. exposure: Gradual cooling to 18.6 degrees C for non-shivering thermogenesis and 11.6 degrees C for shivering onset evidence_span: {"source_cache": "artifacts/cold-research/32948898.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "699fc07665c5f8800951348b6948dba539ed6aed5d1d354d4793be8f9f731b6a", "start_char": 0, "end_char": 1697, "text_sha256": "699fc07665c5f8800951348b6948dba539ed6aed5d1d354d4793be8f9f731b6a"} [cold-p32948898] Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans. (2020). https://pubmed.ncbi.nlm.nih.gov/32948898/ DOI: 10.1007/s00421-020-04496-1
    Complete structured claim and evidence

  2. Heat produced by the thermogenic action of adrenaline may represent more than a quarter of total cold thermogenesis, and in winter swimmers shivering was induced later during cooling, after 40 minutes, suggesting an important contribution of non-shivering thermogenesis to the early thermogenic response.

    Epinephrine → Catecholamine-driven cold thermogenesis source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/cold-research/10825419.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "df5b07f571e51ae21572ac56aa97d1a9dffcd44fe8f5ead4c929086cbbd37e62", "start_char": 0, "end_char": 2308, "text_sha256": "df5b07f571e51ae21572ac56aa97d1a9dffcd44fe8f5ead4c929086cbbd37e62"}
    experimental_model
    Cold-adapted winter swimmers and controls during one hour of immersion at 13 degrees C
    exposure
    One hour of cold water immersion at 13 degrees C
    limitations
    A comparison of adapted and unadapted people. The adrenaline contribution to thermogenesis is the authors’ estimate from their thermoregulation data, not a direct measurement of a hormone-driven heat fraction.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Human
    plain_language
    A quarter of the heat may come from a hormone rather than from muscle shaking.
    primary_references
    [cold-p10825419] Thermoregulation in winter swimmers and physiological significance of human catecholamine thermogenesis. (2000). https://pubmed.ncbi.nlm.nih.gov/10825419/ DOI: 10.1111/j.1469-445x.2000.01909.x
    tissue_or_cell_type
    Whole body thermoregulation

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 624–635

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cold-adapted winter swimmers and controls during one hour of immersion at 13 degrees C · source_derived_draft · unverified_draft

    ### cold-catecholamine-thermogenesis-share Heat produced by the thermogenic action of adrenaline may represent more than a quarter of total cold thermogenesis, and in winter swimmers shivering was induced later during cooling, after 40 minutes, suggesting an important contribution of non-shivering thermogenesis to the early thermogenic response. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: A quarter of the heat may come from a hormone rather than from muscle shaking. organism: Human tissue_or_cell_type: Whole body thermoregulation experimental_model: Cold-adapted winter swimmers and controls during one hour of immersion at 13 degrees C limitations: A comparison of adapted and unadapted people. The adrenaline contribution to thermogenesis is the authors’ estimate from their thermoregulation data, not a direct measurement of a hormone-driven heat fraction. exposure: One hour of cold water immersion at 13 degrees C evidence_span: {"source_cache": "artifacts/cold-research/10825419.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "df5b07f571e51ae21572ac56aa97d1a9dffcd44fe8f5ead4c929086cbbd37e62", "start_char": 0, "end_char": 2308, "text_sha256": "df5b07f571e51ae21572ac56aa97d1a9dffcd44fe8f5ead4c929086cbbd37e62"} [cold-p10825419] Thermoregulation in winter swimmers and physiological significance of human catecholamine thermogenesis. (2000). https://pubmed.ncbi.nlm.nih.gov/10825419/ DOI: 10.1111/j.1469-445x.2000.01909.x
    Complete structured claim and evidence

  3. Cold-exposed Dio2-disrupted mice became hypothermic due to impaired brown adipose thermogenesis despite normal plasma T3 and normal basal UCP1, and survived by compensatory shivering with acute weight loss.

    Experimental Dio2-disrupted mouse genotype → Brown adipose tissue thermogenesis source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/cold-research/11696583.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "adbd82ff8c43d8a2718cfa752c9a0607c367648d6573b968eb885c883376dc68", "start_char": 0, "end_char": 1332, "text_sha256": "adbd82ff8c43d8a2718cfa752c9a0607c367648d6573b968eb885c883376dc68"}
    experimental_model
    Mice with targeted disruption of the Dio2 gene, with brown adipocyte assays and T3 rescue
    exposure
    Cold stress, with norepinephrine, CL316,243 or forskolin stimulation, and a single T3 injection
    limitations
    The selenoenzyme is the link between thyroid hormone and sympathetic signalling. Plasma T3 was normal in the knockouts, so the defect is local hormone generation, not circulating hormone.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Mouse
    plain_language
    Normal hormone in the blood was not enough; the tissue had to make its own.
    primary_references
    [cold-p11696583] The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. (2001). https://pubmed.ncbi.nlm.nih.gov/11696583/ DOI: 10.1172/jci13803
    tissue_or_cell_type
    Brown adipose tissue
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 390–401

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mice with targeted disruption of the Dio2 gene, with brown adipocyte assays and T3 rescue · source_derived_draft · unverified_draft

    ### cold-dio2-null-hypothermia Cold-exposed Dio2-disrupted mice became hypothermic due to impaired brown adipose thermogenesis despite normal plasma T3 and normal basal UCP1, and survived by compensatory shivering with acute weight loss. Condition category: nutrient_deficiency nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Normal hormone in the blood was not enough; the tissue had to make its own. organism: Mouse tissue_or_cell_type: Brown adipose tissue experimental_model: Mice with targeted disruption of the Dio2 gene, with brown adipocyte assays and T3 rescue limitations: The selenoenzyme is the link between thyroid hormone and sympathetic signalling. Plasma T3 was normal in the knockouts, so the defect is local hormone generation, not circulating hormone. exposure: Cold stress, with norepinephrine, CL316,243 or forskolin stimulation, and a single T3 injection evidence_span: {"source_cache": "artifacts/cold-research/11696583.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "adbd82ff8c43d8a2718cfa752c9a0607c367648d6573b968eb885c883376dc68", "start_char": 0, "end_char": 1332, "text_sha256": "adbd82ff8c43d8a2718cfa752c9a0607c367648d6573b968eb885c883376dc68"} [cold-p11696583] The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. (2001). https://pubmed.ncbi.nlm.nih.gov/11696583/ DOI: 10.1172/jci13803
    Complete structured claim and evidence

  4. UCP1-ablated mice acclimated to 4 degrees C sustained heat production at four times resting levels entirely by shivering, with no substitution by any adaptive non-shivering thermogenic process in muscle or any other organ, and neither UCP2 nor UCP3 could substitute.

    Human mitochondrial uncoupling protein 1 / UCP1 → Non-shivering thermogenesis source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/cold-research/11511509.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6e49074478632e22aff36d236fa55e5afb956a4b335f7d95d2cae6f02c4f3d05", "start_char": 0, "end_char": 1527, "text_sha256": "6e49074478632e22aff36d236fa55e5afb956a4b335f7d95d2cae6f02c4f3d05"}
    experimental_model
    UCP1-ablated mice acclimated successively to 4 degrees C
    exposure
    Successive cold acclimation with heat production at four times resting level
    limitations
    A demanding negative result: no substitute for the protein was recruited even under extreme thermogenic demand. It is a mouse result about adaptive non-shivering thermogenesis specifically.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Mouse
    plain_language
    Only one protein can produce adaptive heat without shivering; nothing else stands in for it.
    primary_references
    [cold-p11511509] Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. (2001). https://pubmed.ncbi.nlm.nih.gov/11511509/ DOI: 10.1096/fj.00-0536fje
    tissue_or_cell_type
    Brown adipose tissue, muscle and whole body
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 312–323

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · UCP1-ablated mice acclimated successively to 4 degrees C · source_derived_draft · unverified_draft

    ### cold-ucp1-only-mediator UCP1-ablated mice acclimated to 4 degrees C sustained heat production at four times resting levels entirely by shivering, with no substitution by any adaptive non-shivering thermogenic process in muscle or any other organ, and neither UCP2 nor UCP3 could substitute. Condition category: machinery_impairment nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Only one protein can produce adaptive heat without shivering; nothing else stands in for it. organism: Mouse tissue_or_cell_type: Brown adipose tissue, muscle and whole body experimental_model: UCP1-ablated mice acclimated successively to 4 degrees C limitations: A demanding negative result: no substitute for the protein was recruited even under extreme thermogenic demand. It is a mouse result about adaptive non-shivering thermogenesis specifically. exposure: Successive cold acclimation with heat production at four times resting level evidence_span: {"source_cache": "artifacts/cold-research/11511509.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6e49074478632e22aff36d236fa55e5afb956a4b335f7d95d2cae6f02c4f3d05", "start_char": 0, "end_char": 1527, "text_sha256": "6e49074478632e22aff36d236fa55e5afb956a4b335f7d95d2cae6f02c4f3d05"} [cold-p11511509] Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. (2001). https://pubmed.ncbi.nlm.nih.gov/11511509/ DOI: 10.1096/fj.00-0536fje
    Complete structured claim and evidence

  5. In conscious mice exposed to cooling at 10 degrees, TRPV1 activation by dihydrocapsaicin substantially suppressed total electromyographic muscle activity from 25.6 to 5.1 volt-seconds per minute, abolished the tachycardic response with heart rate change falling from 204 to 3 beats per minute, and produced a profound drop in core temperature from -2.2 to -8.9 degrees.

    Dihydrocapsaicin → The cold-defence response that opposes induced cooling source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/dihydrocapsaicin-research/24005250.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e9d99ac4cc7a031474975ac4d7f3bcff0df922dc01047fe94bd51817ef5b3fea", "start_char": 0, "end_char": 1963, "text_sha256": "e9d99ac4cc7a031474975ac4d7f3bcff0df922dc01047fe94bd51817ef5b3fea"}
    experimental_model
    Conscious mice exposed to 10 degree cooling with implanted electromyography electrodes, electrocardiography and abdominal temperature transmitters
    exposure
    TRPV1 agonist dihydrocapsaicin or TRPM8 inhibitor compound 5, with TRPM8 knockout mice as a control
    limitations
    This is the record that explains why the drug is clinically interesting rather than merely cooling: it removes the defence that makes physical cooling intolerable in a conscious patient.
    nutrient_topic
    Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
    organism
    Mouse
    plain_language
    It switches off the shivering and racing heart that normally fight off cooling, so the temperature falls much further.
    primary_references
    [dhc-p24005250] Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition. (2013). https://pubmed.ncbi.nlm.nih.gov/24005250/ DOI: 10.1152/ajpregu.00296.2013
    tissue_or_cell_type
    Back muscle, heart and core

    Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 244–255

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Conscious mice exposed to 10 degree cooling with implanted electromyography electrodes, electrocardiography and abdominal temperature transmitters · source_derived_draft · unverified_draft

    ### dhc-suppresses-cold-defence In conscious mice exposed to cooling at 10 degrees, TRPV1 activation by dihydrocapsaicin substantially suppressed total electromyographic muscle activity from 25.6 to 5.1 volt-seconds per minute, abolished the tachycardic response with heart rate change falling from 204 to 3 beats per minute, and produced a profound drop in core temperature from -2.2 to -8.9 degrees. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: It switches off the shivering and racing heart that normally fight off cooling, so the temperature falls much further. organism: Mouse tissue_or_cell_type: Back muscle, heart and core experimental_model: Conscious mice exposed to 10 degree cooling with implanted electromyography electrodes, electrocardiography and abdominal temperature transmitters limitations: This is the record that explains why the drug is clinically interesting rather than merely cooling: it removes the defence that makes physical cooling intolerable in a conscious patient. exposure: TRPV1 agonist dihydrocapsaicin or TRPM8 inhibitor compound 5, with TRPM8 knockout mice as a control evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/24005250.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e9d99ac4cc7a031474975ac4d7f3bcff0df922dc01047fe94bd51817ef5b3fea", "start_char": 0, "end_char": 1963, "text_sha256": "e9d99ac4cc7a031474975ac4d7f3bcff0df922dc01047fe94bd51817ef5b3fea"} [dhc-p24005250] Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition. (2013). https://pubmed.ncbi.nlm.nih.gov/24005250/ DOI: 10.1152/ajpregu.00296.2013
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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