{"id":"c0067612-6488-5633-b39f-608ac2cf7f69","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-bat-shivering-inverse","predicate":"reduces","statement":"An inverse relationship was found between brown adipose tissue activity and shivering, and brown adipose tissue radio density increased upon cold exposure, indicating reduced triglyceride content.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"5556502c-9b33-5781-8238-50703196ba75","mechanism_event_label":"The more this tissue works, the less you shiver, and it visibly uses up its own fat.","subject":{"id":"2c86dbab-dc28-5eb5-80f1-62757171d308","slug":"bat-oxidative-metabolism","display_name":"Brown adipose tissue oxidative metabolism","entity_type_key":"cellular_process"},"object":{"id":"4d0ab5e4-8743-5a7c-8692-57e6d096c4e9","slug":"shivering","display_name":"Shivering thermogenesis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5556502c-9b33-5781-8238-50703196ba75","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-bat-shivering-inverse-event","event_type":"observed_intervention","label":"The more this tissue works, the less you shiver, and it visibly uses up its own fat.","description":"An inverse relationship was found between brown adipose tissue activity and shivering, and brown adipose tissue radio density increased upon cold exposure, indicating reduced triglyceride content.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b2ae68c3-9707-58f4-8f67-8b0179831f6f","slug":"bat-triglyceride-content","display_name":"Brown adipose tissue triglyceride content","entity_type_key":"cellular_process"},"role":"depleted_store","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2c86dbab-dc28-5eb5-80f1-62757171d308","slug":"bat-oxidative-metabolism","display_name":"Brown adipose tissue oxidative metabolism","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4d0ab5e4-8743-5a7c-8692-57e6d096c4e9","slug":"shivering","display_name":"Shivering thermogenesis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/cold-research/22269323.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"74713401a7fdc40f7921b595ecc554999d10e2406589f231fc68bf0ae460812f\", \"start_char\": 0, \"end_char\": 1306, \"text_sha256\": \"74713401a7fdc40f7921b595ecc554999d10e2406589f231fc68bf0ae460812f\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six healthy men studied with 11C-acetate, 18FDG and a fatty acid tracer under controlled cold","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Controlled cold exposure with quantified oxidative metabolism and substrate turnover","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The acetate tracer measures oxidative metabolism rather than glucose uptake alone, which is what makes the thermogenic claim interpretable. Six subjects is a small sample.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The more this tissue works, the less you shiver, and it visibly uses up its own fat.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p22269323] Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. (2012). https://pubmed.ncbi.nlm.nih.gov/22269323/ DOI: 10.1172/jci60433","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brown adipose tissue, skeletal muscle and subcutaneous fat","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8f945a79-dbaf-53f8-9d63-2a4a77accac0","evidence_kind":"source_excerpt","locator":"Lines 286-297","start_line":286,"end_line":297,"excerpt":"### cold-bat-shivering-inverse\nAn inverse relationship was found between brown adipose tissue activity and shivering, and brown adipose tissue radio density increased upon cold exposure, indicating reduced triglyceride content.\nCondition category: normal\nnutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.\nplain_language: The more this tissue works, the less you shiver, and it visibly uses up its own fat.\norganism: Human\ntissue_or_cell_type: Brown adipose tissue, skeletal muscle and subcutaneous fat\nexperimental_model: Six healthy men studied with 11C-acetate, 18FDG and a fatty acid tracer under controlled cold\nlimitations: The acetate tracer measures oxidative metabolism rather than glucose uptake alone, which is what makes the thermogenic claim interpretable. Six subjects is a small sample.\nexposure: Controlled cold exposure with quantified oxidative metabolism and substrate turnover\nevidence_span: {\"source_cache\": \"artifacts/cold-research/22269323.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"74713401a7fdc40f7921b595ecc554999d10e2406589f231fc68bf0ae460812f\", \"start_char\": 0, \"end_char\": 1306, \"text_sha256\": \"74713401a7fdc40f7921b595ecc554999d10e2406589f231fc68bf0ae460812f\"}\n[cold-p22269323] Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. (2012). https://pubmed.ncbi.nlm.nih.gov/22269323/ DOI: 10.1172/jci60433","model_system":"Six healthy men studied with 11C-acetate, 18FDG and a fatty acid tracer under controlled cold","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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