Component

Serum dihydrotestosterone concentration

Serum dihydrotestosterone concentration. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. DHT rose 56% after loading and remained 40% above baseline after maintenance in the creatine condition; serum testosterone did not change.

    Creatine → Serum dihydrotestosterone concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/creatine-research/19741313.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1a90f951d101c58728a098b31f98db2fe8c509d5811d7a08e5b2052cd930f1d3", "start_char": 0, "end_char": 1975, "text_sha256": "1a90f951d101c58728a098b31f98db2fe8c509d5811d7a08e5b2052cd930f1d3"}
    experimental_model
    Double-blind placebo-controlled crossover study
    exposure
    25 g/day creatine with glucose for seven days then 5 g/day for 14 days
    limitations
    DHT was measured, not hair loss; the proposed increased testosterone-to-DHT conversion was an interpretation, not an enzyme assay.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    20 college-aged male rugby players
    plain_language
    This small study reported a hormone change but did not measure hair loss.
    primary_references
    [creatine-p19741313] Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. (2009). https://pubmed.ncbi.nlm.nih.gov/19741313/ DOI: 10.1097/jsm.0b013e3181b8b52f
    tissue_or_cell_type
    Serum hormones

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 1153–1164

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind placebo-controlled crossover study · source_derived_draft · unverified_draft

    ### creatine-dht-loading-study DHT rose 56% after loading and remained 40% above baseline after maintenance in the creatine condition; serum testosterone did not change. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: This small study reported a hormone change but did not measure hair loss. organism: 20 college-aged male rugby players tissue_or_cell_type: Serum hormones experimental_model: Double-blind placebo-controlled crossover study limitations: DHT was measured, not hair loss; the proposed increased testosterone-to-DHT conversion was an interpretation, not an enzyme assay. exposure: 25 g/day creatine with glucose for seven days then 5 g/day for 14 days evidence_span: {"source_cache": "artifacts/creatine-research/19741313.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1a90f951d101c58728a098b31f98db2fe8c509d5811d7a08e5b2052cd930f1d3", "start_char": 0, "end_char": 1975, "text_sha256": "1a90f951d101c58728a098b31f98db2fe8c509d5811d7a08e5b2052cd930f1d3"} [creatine-p19741313] Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. (2009). https://pubmed.ncbi.nlm.nih.gov/19741313/ DOI: 10.1097/jsm.0b013e3181b8b52f
    Complete structured claim and evidence

  2. There were no significant group-by-time differences in DHT or DHT-to-testosterone ratio after 12 weeks.

    Creatine monohydrate → Serum dihydrotestosterone concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/creatine-research/40265319.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dede40817f51a6dbe3d53dc09cefa031cee507182056cb23c068678563dfb2bf", "start_char": 0, "end_char": 2039, "text_sha256": "dede40817f51a6dbe3d53dc09cefa031cee507182056cb23c068678563dfb2bf"}
    experimental_model
    Twelve-week randomized placebo-controlled trial
    exposure
    Creatine monohydrate 5 g/day versus maltodextrin placebo
    limitations
    Different dose and duration from the 2009 loading study; short follow-up cannot establish every long-term or genetically susceptible outcome.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    38 completing resistance-trained men out of 45 recruited
    plain_language
    A later maintenance-dose trial did not reproduce the earlier hormone signal.
    primary_references
    [creatine-p40265319] Does creatine cause hair loss? A 12-week randomized controlled trial. (2025). https://pubmed.ncbi.nlm.nih.gov/40265319/ DOI: 10.1080/15502783.2025.2495229
    tissue_or_cell_type
    Serum hormones and objective hair measurements

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 1166–1177

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Twelve-week randomized placebo-controlled trial · source_derived_draft · unverified_draft

    ### creatine-dht-maintenance-study There were no significant group-by-time differences in DHT or DHT-to-testosterone ratio after 12 weeks. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A later maintenance-dose trial did not reproduce the earlier hormone signal. organism: 38 completing resistance-trained men out of 45 recruited tissue_or_cell_type: Serum hormones and objective hair measurements experimental_model: Twelve-week randomized placebo-controlled trial limitations: Different dose and duration from the 2009 loading study; short follow-up cannot establish every long-term or genetically susceptible outcome. exposure: Creatine monohydrate 5 g/day versus maltodextrin placebo evidence_span: {"source_cache": "artifacts/creatine-research/40265319.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dede40817f51a6dbe3d53dc09cefa031cee507182056cb23c068678563dfb2bf", "start_char": 0, "end_char": 2039, "text_sha256": "dede40817f51a6dbe3d53dc09cefa031cee507182056cb23c068678563dfb2bf"} [creatine-p40265319] Does creatine cause hair loss? A 12-week randomized controlled trial. (2025). https://pubmed.ncbi.nlm.nih.gov/40265319/ DOI: 10.1080/15502783.2025.2495229
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards