{"id":"2d03ece2-ffe8-5889-be5a-5f73def90bbe","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-dht-maintenance-study","predicate":"did_not_significantly_change","statement":"There were no significant group-by-time differences in DHT or DHT-to-testosterone ratio after 12 weeks.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b5e4375f-5b70-5ebb-b599-232b45839819","mechanism_event_label":"A later maintenance-dose trial did not reproduce the earlier hormone signal.","subject":{"id":"399b373f-0034-5f2b-83b7-637eb2678c83","slug":"creatine-monohydrate","display_name":"Creatine monohydrate","entity_type_key":"small_molecule"},"object":{"id":"98b3f62d-1e63-5c5f-b91c-64e407678644","slug":"serum-dht-concentration","display_name":"Serum dihydrotestosterone concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b5e4375f-5b70-5ebb-b599-232b45839819","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-dht-maintenance-study-event","event_type":"observed_intervention","label":"A later maintenance-dose trial did not reproduce the earlier hormone signal.","description":"There were no significant group-by-time differences in DHT or DHT-to-testosterone ratio after 12 weeks.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"399b373f-0034-5f2b-83b7-637eb2678c83","slug":"creatine-monohydrate","display_name":"Creatine monohydrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"98b3f62d-1e63-5c5f-b91c-64e407678644","slug":"serum-dht-concentration","display_name":"Serum dihydrotestosterone concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/40265319.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"dede40817f51a6dbe3d53dc09cefa031cee507182056cb23c068678563dfb2bf\", \"start_char\": 0, \"end_char\": 2039, \"text_sha256\": \"dede40817f51a6dbe3d53dc09cefa031cee507182056cb23c068678563dfb2bf\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twelve-week randomized placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Creatine monohydrate 5 g/day versus maltodextrin placebo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different dose and duration from the 2009 loading study; short follow-up cannot establish every long-term or genetically susceptible outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Creatine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"38 completing resistance-trained men out of 45 recruited","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A later maintenance-dose trial did not reproduce the earlier hormone signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[creatine-p40265319] Does creatine cause hair loss? A 12-week randomized controlled trial. (2025). https://pubmed.ncbi.nlm.nih.gov/40265319/ DOI: 10.1080/15502783.2025.2495229","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum hormones and objective hair measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f25ae735-9525-5b91-b826-5cb3f3aeb44a","evidence_kind":"source_excerpt","locator":"Lines 1166-1177","start_line":1166,"end_line":1177,"excerpt":"### creatine-dht-maintenance-study\nThere were no significant group-by-time differences in DHT or DHT-to-testosterone ratio after 12 weeks.\nCondition category: normal\nnutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A later maintenance-dose trial did not reproduce the earlier hormone signal.\norganism: 38 completing resistance-trained men out of 45 recruited\ntissue_or_cell_type: Serum hormones and objective hair measurements\nexperimental_model: Twelve-week randomized placebo-controlled trial\nlimitations: Different dose and duration from the 2009 loading study; short follow-up cannot establish every long-term or genetically susceptible outcome.\nexposure: Creatine monohydrate 5 g/day versus maltodextrin placebo\nevidence_span: {\"source_cache\": \"artifacts/creatine-research/40265319.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"dede40817f51a6dbe3d53dc09cefa031cee507182056cb23c068678563dfb2bf\", \"start_char\": 0, \"end_char\": 2039, \"text_sha256\": \"dede40817f51a6dbe3d53dc09cefa031cee507182056cb23c068678563dfb2bf\"}\n[creatine-p40265319] Does creatine cause hair loss? 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