{"id":"62b24231-e042-5294-9ca3-75e44fe4f212","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-dht-loading-study","predicate":"associated_with_increase_in","statement":"DHT rose 56% after loading and remained 40% above baseline after maintenance in the creatine condition; serum testosterone did not change.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ba6d4175-1fc8-5082-a21a-d2d412b15aca","mechanism_event_label":"This small study reported a hormone change but did not measure hair loss.","subject":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"object":{"id":"98b3f62d-1e63-5c5f-b91c-64e407678644","slug":"serum-dht-concentration","display_name":"Serum dihydrotestosterone concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ba6d4175-1fc8-5082-a21a-d2d412b15aca","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-dht-loading-study-event","event_type":"observed_intervention","label":"This small study reported a hormone change but did not measure hair loss.","description":"DHT rose 56% after loading and remained 40% above baseline after maintenance in the creatine condition; serum testosterone did not change.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"98b3f62d-1e63-5c5f-b91c-64e407678644","slug":"serum-dht-concentration","display_name":"Serum dihydrotestosterone concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/19741313.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1a90f951d101c58728a098b31f98db2fe8c509d5811d7a08e5b2052cd930f1d3\", \"start_char\": 0, \"end_char\": 1975, \"text_sha256\": \"1a90f951d101c58728a098b31f98db2fe8c509d5811d7a08e5b2052cd930f1d3\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind placebo-controlled crossover study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"25 g/day creatine with glucose for seven days then 5 g/day for 14 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"DHT was measured, not hair loss; the proposed increased testosterone-to-DHT conversion was an interpretation, not an enzyme assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Creatine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"20 college-aged male rugby players","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This small study reported a hormone change but did not measure hair loss.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[creatine-p19741313] Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. (2009). https://pubmed.ncbi.nlm.nih.gov/19741313/ DOI: 10.1097/jsm.0b013e3181b8b52f","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum hormones","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6195aacc-2223-5784-8ea8-1817f47e43fb","evidence_kind":"source_excerpt","locator":"Lines 1153-1164","start_line":1153,"end_line":1164,"excerpt":"### creatine-dht-loading-study\nDHT rose 56% after loading and remained 40% above baseline after maintenance in the creatine condition; serum testosterone did not change.\nCondition category: normal\nnutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This small study reported a hormone change but did not measure hair loss.\norganism: 20 college-aged male rugby players\ntissue_or_cell_type: Serum hormones\nexperimental_model: Double-blind placebo-controlled crossover study\nlimitations: DHT was measured, not hair loss; the proposed increased testosterone-to-DHT conversion was an interpretation, not an enzyme assay.\nexposure: 25 g/day creatine with glucose for seven days then 5 g/day for 14 days\nevidence_span: {\"source_cache\": \"artifacts/creatine-research/19741313.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1a90f951d101c58728a098b31f98db2fe8c509d5811d7a08e5b2052cd930f1d3\", \"start_char\": 0, \"end_char\": 1975, \"text_sha256\": \"1a90f951d101c58728a098b31f98db2fe8c509d5811d7a08e5b2052cd930f1d3\"}\n[creatine-p19741313] Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. (2009). https://pubmed.ncbi.nlm.nih.gov/19741313/ DOI: 10.1097/jsm.0b013e3181b8b52f","model_system":"Double-blind placebo-controlled crossover study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [creatine-p19741313] Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. (2009). https://pubmed.ncbi.nlm.nih.gov/19741313/ DOI: 10.1097/jsm.0b013e3181b8b52f","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"70358046-c5c3-5e9a-9fc9-eb01c3fff88b","stable_key":"import-44737fa3-b335-53f4-a644-b9878d4416ac","title":"Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"548237d3e98a73a7dc02181807921fdd8b902adcee46248792258a761593eda9","revision_id":"88738255-8028-52fb-9c12-0fe92d8ce367","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}