Component
2026 comparator salicylic-acid acne patch
Preparation-specific actor; do not transfer all outcomes to a constituent.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Skin sebum decreased over 48 hours with the salicylic-acid-patch-2026 intervention.
Experimental context and source evidence
- evidence_access
- Primary full-text methods/results reviewed. Published January 2026 despite 2025 in DOI.
- experimental_contrast
- {"intervention": "Specified patch", "comparator": "Same treated site before patch", "endpoint": "Skin sebum decreased over 48 hours with the salicylic-acid-patch-2026 intervention.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- 15 volunteers, open-label nonrandomized split-body comparison.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Mixed formulation or active comparator; no placebo isolation or isolated SA clinical efficacy.
- plain_language
- Skin sebum decreased over 48 hours with the salicylic-acid-patch-2026 intervention.
- primary_references
- Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment | 2026 | DOI 10.3389/fntpr.2025.1737986 | https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full
- source_locator
- Reviewed reference lines 83-83; exact primary location described in quoted passage where extracted.
Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 83–83
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · 15 volunteers, open-label nonrandomized split-body comparison. · source_derived_draft · unverified_draft
**A mixed patch does not isolate shikimic acid efficacy.** The same report studied patches containing 0.5% shikimic acid and 0.5% P. mume extract plus additional formulation constituents in 15 volunteers aged 18–28. It was open-label, nonrandomized and split-body, over 48 h. Sebum decreased with both this patch and a 0.5% salicylic-acid comparator; the between-patch difference was not significant (p=0.12). No adverse skin effects were reported in this small short study. It does not establish isolated shikimic acid efficacy, long-term safety, oral antiandrogen action or synergy. [Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment](https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full)
Complete structured claim and evidence
Where it participates (unsigned role)
The between-patch sebum difference did not reach significance (p=0.12).
Experimental context and source evidence
- evidence_access
- Primary full-text methods/results reviewed. Published January 2026 despite 2025 in DOI.
- experimental_contrast
- {"intervention": "Mixed SA/P. mume patch", "comparator": "0.5% salicylic-acid patch", "endpoint": "The between-patch sebum difference did not reach significance (p=0.12).", "effect_direction": "no_detected_change", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Same 15-person 48-hour study.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Nonsignificance does not establish equivalence or synergy.
- plain_language
- The between-patch sebum difference did not reach significance (p=0.12).
- primary_references
- Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment | 2026 | DOI 10.3389/fntpr.2025.1737986 | https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full
- source_locator
- Reviewed reference lines 83-83; exact primary location described in quoted passage where extracted.
Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 83–83
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Same 15-person 48-hour study. · source_derived_draft · unverified_draft
**A mixed patch does not isolate shikimic acid efficacy.** The same report studied patches containing 0.5% shikimic acid and 0.5% P. mume extract plus additional formulation constituents in 15 volunteers aged 18–28. It was open-label, nonrandomized and split-body, over 48 h. Sebum decreased with both this patch and a 0.5% salicylic-acid comparator; the between-patch difference was not significant (p=0.12). No adverse skin effects were reported in this small short study. It does not establish isolated shikimic acid efficacy, long-term safety, oral antiandrogen action or synergy. [Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment](https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.