{"id":"12b87d42-9ba3-5a21-9f44-500777772b07","stable_key":"31b1baa4-4113-5541-b9e7-fe44a5253a07:sebum-between-null","predicate":"no_detected_change_in_recorded_experiment","statement":"The between-patch sebum difference did not reach significance (p=0.12).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"a7e60379-bfcb-5d5f-a014-722c99495cef","mechanism_event_label":"The between-patch sebum difference did not reach significance (p=0.12).","subject":{"id":"efeb7652-8fe6-5ac9-a77f-ec49c8e6bf24","slug":"shikimic-acid-prunus-patch-2026","display_name":"2026 mixed shikimic-acid/Prunus-mume acne patch","entity_type_key":"chemical_species"},"object":{"id":"e5e1b50f-4adb-5bcc-a219-fc205b1f137d","slug":"human-patch-sebum","display_name":"Human skin sebum during the 2026 patch study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a7e60379-bfcb-5d5f-a014-722c99495cef","stable_key":"31b1baa4-4113-5541-b9e7-fe44a5253a07:sebum-between-null-event","event_type":"experimental_observation","label":"The between-patch sebum difference did not reach significance (p=0.12).","description":"**A mixed patch does not isolate shikimic acid efficacy.** The same report studied patches containing 0.5% shikimic acid and 0.5% P. mume extract plus additional formulation constituents in 15 volunteers aged 18–28. It was open-label, nonrandomized and split-body, over 48 h. Sebum decreased with both this patch and a 0.5% salicylic-acid comparator; the between-patch difference was not significant (p=0.12). No adverse skin effects were reported in this small short study. It does not establish isolated shikimic acid efficacy, long-term safety, oral antiandrogen action or synergy. [Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment](https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"efeb7652-8fe6-5ac9-a77f-ec49c8e6bf24","slug":"shikimic-acid-prunus-patch-2026","display_name":"2026 mixed shikimic-acid/Prunus-mume acne patch","entity_type_key":"chemical_species"},"role":"tested factor","stoichiometry":null,"state_label":"Mixed SA/P. mume patch","sequence_order":0,"notes":""},{"entity":{"id":"e5e1b50f-4adb-5bcc-a219-fc205b1f137d","slug":"human-patch-sebum","display_name":"Human skin sebum during the 2026 patch study","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"no_detected_change","sequence_order":1,"notes":""},{"entity":{"id":"6afa4116-3725-58d8-b4e2-34c2d5d2891c","slug":"salicylic-acid-patch-2026","display_name":"2026 comparator salicylic-acid acne patch","entity_type_key":"chemical_species"},"role":"active comparator","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full-text methods/results reviewed. Published January 2026 despite 2025 in DOI.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Mixed SA/P. mume patch\", \"comparator\": \"0.5% salicylic-acid patch\", \"endpoint\": \"The between-patch sebum difference did not reach significance (p=0.12).\", \"effect_direction\": \"no_detected_change\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Same 15-person 48-hour study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Nonsignificance does not establish equivalence or synergy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The between-patch sebum difference did not reach significance (p=0.12).","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment | 2026 | DOI 10.3389/fntpr.2025.1737986 | https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 83-83; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5bde4a2d-4e75-56b6-a4bf-87db449bdf74","evidence_kind":"source_excerpt","locator":"Lines 83-83","start_line":83,"end_line":83,"excerpt":"**A mixed patch does not isolate shikimic acid efficacy.** The same report studied patches containing 0.5% shikimic acid and 0.5% P. mume extract plus additional formulation constituents in 15 volunteers aged 18–28. It was open-label, nonrandomized and split-body, over 48 h. Sebum decreased with both this patch and a 0.5% salicylic-acid comparator; the between-patch difference was not significant (p=0.12). No adverse skin effects were reported in this small short study. It does not establish isolated shikimic acid efficacy, long-term safety, oral antiandrogen action or synergy. [Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment](https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full)","model_system":"Same 15-person 48-hour study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e6ae59de-0369-5c2f-8262-57d91302671c","stable_key":"import-31b1baa4-4113-5541-b9e7-fe44a5253a07","title":"Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"95b1f9e9577661312d67f36e156d2e49326b207f296c1c0e801a5b007fd8e283","revision_id":"cd3237f1-131a-557d-84b5-7543259807b0","review_status":"unverified_draft","notes":""}}],"relations":[{"id":"901ce363-9b3f-5aa8-b320-681f4f9779a1","relation_type":"limits_scope_of","notes":"Within-site change does not prove superiority over the active comparator.","source_claim_id":"12b87d42-9ba3-5a21-9f44-500777772b07","source_claim_key":"31b1baa4-4113-5541-b9e7-fe44a5253a07:sebum-between-null","source_statement":"The between-patch sebum difference did not reach significance (p=0.12).","target_claim_id":"3caed4e7-7e27-5fda-8f92-12435d460c9b","target_claim_key":"31b1baa4-4113-5541-b9e7-fe44a5253a07:sebum-shikimic-acid-prunus-patch-2026","target_statement":"Skin sebum decreased over 48 hours with the shikimic-acid-prunus-patch-2026 intervention."}],"conflicts":[],"corrections":[],"research":null}