Component

Human skin sebum during the 2026 patch study

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The between-patch sebum difference did not reach significance (p=0.12).

    2026 mixed shikimic-acid/Prunus-mume acne patch → Human skin sebum during the 2026 patch study source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full-text methods/results reviewed. Published January 2026 despite 2025 in DOI.
    experimental_contrast
    {"intervention": "Mixed SA/P. mume patch", "comparator": "0.5% salicylic-acid patch", "endpoint": "The between-patch sebum difference did not reach significance (p=0.12).", "effect_direction": "no_detected_change", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Same 15-person 48-hour study.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Nonsignificance does not establish equivalence or synergy.
    plain_language
    The between-patch sebum difference did not reach significance (p=0.12).
    primary_references
    Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment | 2026 | DOI 10.3389/fntpr.2025.1737986 | https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full
    source_locator
    Reviewed reference lines 83-83; exact primary location described in quoted passage where extracted.

    Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 83–83

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Same 15-person 48-hour study. · source_derived_draft · unverified_draft

    **A mixed patch does not isolate shikimic acid efficacy.** The same report studied patches containing 0.5% shikimic acid and 0.5% P. mume extract plus additional formulation constituents in 15 volunteers aged 18–28. It was open-label, nonrandomized and split-body, over 48 h. Sebum decreased with both this patch and a 0.5% salicylic-acid comparator; the between-patch difference was not significant (p=0.12). No adverse skin effects were reported in this small short study. It does not establish isolated shikimic acid efficacy, long-term safety, oral antiandrogen action or synergy. [Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment](https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full)
    Complete structured claim and evidence

  2. Skin sebum decreased over 48 hours with the salicylic-acid-patch-2026 intervention.

    2026 comparator salicylic-acid acne patch → Human skin sebum during the 2026 patch study source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full-text methods/results reviewed. Published January 2026 despite 2025 in DOI.
    experimental_contrast
    {"intervention": "Specified patch", "comparator": "Same treated site before patch", "endpoint": "Skin sebum decreased over 48 hours with the salicylic-acid-patch-2026 intervention.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    15 volunteers, open-label nonrandomized split-body comparison.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Mixed formulation or active comparator; no placebo isolation or isolated SA clinical efficacy.
    plain_language
    Skin sebum decreased over 48 hours with the salicylic-acid-patch-2026 intervention.
    primary_references
    Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment | 2026 | DOI 10.3389/fntpr.2025.1737986 | https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full
    source_locator
    Reviewed reference lines 83-83; exact primary location described in quoted passage where extracted.

    Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 83–83

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · 15 volunteers, open-label nonrandomized split-body comparison. · source_derived_draft · unverified_draft

    **A mixed patch does not isolate shikimic acid efficacy.** The same report studied patches containing 0.5% shikimic acid and 0.5% P. mume extract plus additional formulation constituents in 15 volunteers aged 18–28. It was open-label, nonrandomized and split-body, over 48 h. Sebum decreased with both this patch and a 0.5% salicylic-acid comparator; the between-patch difference was not significant (p=0.12). No adverse skin effects were reported in this small short study. It does not establish isolated shikimic acid efficacy, long-term safety, oral antiandrogen action or synergy. [Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment](https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full)
    Complete structured claim and evidence

  3. Skin sebum decreased over 48 hours with the shikimic-acid-prunus-patch-2026 intervention.

    2026 mixed shikimic-acid/Prunus-mume acne patch → Human skin sebum during the 2026 patch study source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full-text methods/results reviewed. Published January 2026 despite 2025 in DOI.
    experimental_contrast
    {"intervention": "Specified patch", "comparator": "Same treated site before patch", "endpoint": "Skin sebum decreased over 48 hours with the shikimic-acid-prunus-patch-2026 intervention.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    15 volunteers, open-label nonrandomized split-body comparison.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Mixed formulation or active comparator; no placebo isolation or isolated SA clinical efficacy.
    plain_language
    Skin sebum decreased over 48 hours with the shikimic-acid-prunus-patch-2026 intervention.
    primary_references
    Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment | 2026 | DOI 10.3389/fntpr.2025.1737986 | https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full
    source_locator
    Reviewed reference lines 83-83; exact primary location described in quoted passage where extracted.

    Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 83–83

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · 15 volunteers, open-label nonrandomized split-body comparison. · source_derived_draft · unverified_draft

    **A mixed patch does not isolate shikimic acid efficacy.** The same report studied patches containing 0.5% shikimic acid and 0.5% P. mume extract plus additional formulation constituents in 15 volunteers aged 18–28. It was open-label, nonrandomized and split-body, over 48 h. Sebum decreased with both this patch and a 0.5% salicylic-acid comparator; the between-patch difference was not significant (p=0.12). No adverse skin effects were reported in this small short study. It does not establish isolated shikimic acid efficacy, long-term safety, oral antiandrogen action or synergy. [Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment](https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full)
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.