{"id":"a3c43c52-7622-59ab-8f28-a5bbfa637e2c","stable_key":"31b1baa4-4113-5541-b9e7-fe44a5253a07:sebum-salicylic-acid-patch-2026","predicate":"decreases_in_recorded_experiment","statement":"Skin sebum decreased over 48 hours with the salicylic-acid-patch-2026 intervention.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"07448460-c93a-501f-9126-73117aedc707","mechanism_event_label":"Skin sebum decreased over 48 hours with the salicylic-acid-patch-2026 intervention.","subject":{"id":"6afa4116-3725-58d8-b4e2-34c2d5d2891c","slug":"salicylic-acid-patch-2026","display_name":"2026 comparator salicylic-acid acne patch","entity_type_key":"chemical_species"},"object":{"id":"e5e1b50f-4adb-5bcc-a219-fc205b1f137d","slug":"human-patch-sebum","display_name":"Human skin sebum during the 2026 patch study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"07448460-c93a-501f-9126-73117aedc707","stable_key":"31b1baa4-4113-5541-b9e7-fe44a5253a07:sebum-salicylic-acid-patch-2026-event","event_type":"experimental_observation","label":"Skin sebum decreased over 48 hours with the salicylic-acid-patch-2026 intervention.","description":"**A mixed patch does not isolate shikimic acid efficacy.** The same report studied patches containing 0.5% shikimic acid and 0.5% P. mume extract plus additional formulation constituents in 15 volunteers aged 18–28. It was open-label, nonrandomized and split-body, over 48 h. Sebum decreased with both this patch and a 0.5% salicylic-acid comparator; the between-patch difference was not significant (p=0.12). No adverse skin effects were reported in this small short study. It does not establish isolated shikimic acid efficacy, long-term safety, oral antiandrogen action or synergy. [Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment](https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6afa4116-3725-58d8-b4e2-34c2d5d2891c","slug":"salicylic-acid-patch-2026","display_name":"2026 comparator salicylic-acid acne patch","entity_type_key":"chemical_species"},"role":"tested factor","stoichiometry":null,"state_label":"Specified patch","sequence_order":0,"notes":""},{"entity":{"id":"e5e1b50f-4adb-5bcc-a219-fc205b1f137d","slug":"human-patch-sebum","display_name":"Human skin sebum during the 2026 patch study","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"decrease","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full-text methods/results reviewed. Published January 2026 despite 2025 in DOI.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Specified patch\", \"comparator\": \"Same treated site before patch\", \"endpoint\": \"Skin sebum decreased over 48 hours with the salicylic-acid-patch-2026 intervention.\", \"effect_direction\": \"decrease\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"15 volunteers, open-label nonrandomized split-body comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mixed formulation or active comparator; no placebo isolation or isolated SA clinical efficacy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Skin sebum decreased over 48 hours with the salicylic-acid-patch-2026 intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment | 2026 | DOI 10.3389/fntpr.2025.1737986 | https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 83-83; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"40196d1f-6533-5b70-9ca3-0efef7df6375","evidence_kind":"source_excerpt","locator":"Lines 83-83","start_line":83,"end_line":83,"excerpt":"**A mixed patch does not isolate shikimic acid efficacy.** The same report studied patches containing 0.5% shikimic acid and 0.5% P. mume extract plus additional formulation constituents in 15 volunteers aged 18–28. It was open-label, nonrandomized and split-body, over 48 h. Sebum decreased with both this patch and a 0.5% salicylic-acid comparator; the between-patch difference was not significant (p=0.12). No adverse skin effects were reported in this small short study. It does not establish isolated shikimic acid efficacy, long-term safety, oral antiandrogen action or synergy. [Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment](https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full)","model_system":"15 volunteers, open-label nonrandomized split-body comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e6ae59de-0369-5c2f-8262-57d91302671c","stable_key":"import-31b1baa4-4113-5541-b9e7-fe44a5253a07","title":"Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"95b1f9e9577661312d67f36e156d2e49326b207f296c1c0e801a5b007fd8e283","revision_id":"cd3237f1-131a-557d-84b5-7543259807b0","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}