Component

Red yeast rice preparation in the 2005 ICR mouse experiment

Context-specific entity; species, compartment and exposure are stated on each claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. The same acute mouse study reported lower cardiac CoQ10 after red yeast rice gavage, with greater suppression at the higher dose.

    Red yeast rice preparation in the 2005 ICR mouse experiment → Mouse heart CoQ10 after acute red yeast rice gavage source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Male ICR mice, 1 or 5 g/kg oral gavage.
    limitations
    The abstract repeats the heart label in its time-course description; precise tissue-specific onset is not reconstructed from that ambiguous wording.
    nutrient_topic
    Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
    plain_language
    A second tissue showed a measured change.
    primary_references
    [15705235] Acute administration of red yeast rice (Monascus purpureus) depletes tissue coenzyme Q(10) levels in ICR mice. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15705235/ · DOI 10.1079/bjn20041285
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 100–106

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Male ICR mice, 1 or 5 g/kg oral gavage. · source_derived_draft · unverified_draft

    ## red-yeast-rice-mouse-ryr-heart-coq A second tissue showed a measured change. The same acute mouse study reported lower cardiac CoQ10 after red yeast rice gavage, with greater suppression at the higher dose. Model: Male ICR mice, 1 or 5 g/kg oral gavage. Limitations: The abstract repeats the heart label in its time-course description; precise tissue-specific onset is not reconstructed from that ambiguous wording. Evidence access: Primary abstract [15705235] Acute administration of red yeast rice (Monascus purpureus) depletes tissue coenzyme Q(10) levels in ICR mice. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15705235/ · DOI 10.1079/bjn20041285
    Complete structured claim and evidence

  2. Acute red yeast rice gavage at 1 or 5 g/kg reduced hepatic CoQ10 in male ICR mice, with suppression still reported at 24 hours.

    Red yeast rice preparation in the 2005 ICR mouse experiment → Mouse liver CoQ10 after acute red yeast rice gavage source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Soybean-oil preparation; eight mice per experimental subgroup, sampled from 0.5 to 24 hours.
    limitations
    High-dose rodent exposure; the abstract describes controls killed immediately, so time and feeding controls limit interpretation. No human dose equivalence is inferred.
    nutrient_topic
    Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
    plain_language
    The mixture itself was tested in mice at high doses.
    primary_references
    [15705235] Acute administration of red yeast rice (Monascus purpureus) depletes tissue coenzyme Q(10) levels in ICR mice. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15705235/ · DOI 10.1079/bjn20041285
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 92–98

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Soybean-oil preparation; eight mice per experimental subgroup, sampled from 0.5 to 24 hours. · source_derived_draft · unverified_draft

    ## red-yeast-rice-mouse-ryr-liver-coq The mixture itself was tested in mice at high doses. Acute red yeast rice gavage at 1 or 5 g/kg reduced hepatic CoQ10 in male ICR mice, with suppression still reported at 24 hours. Model: Soybean-oil preparation; eight mice per experimental subgroup, sampled from 0.5 to 24 hours. Limitations: High-dose rodent exposure; the abstract describes controls killed immediately, so time and feeding controls limit interpretation. No human dose equivalence is inferred. Evidence access: Primary abstract [15705235] Acute administration of red yeast rice (Monascus purpureus) depletes tissue coenzyme Q(10) levels in ICR mice. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15705235/ · DOI 10.1079/bjn20041285
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards