{"id":"a55c42a9-002b-5ef6-b72c-c23b21eba965","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-mouse-ryr-heart-coq","predicate":"reduces_tested","statement":"The same acute mouse study reported lower cardiac CoQ10 after red yeast rice gavage, with greater suppression at the higher dose.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"e245e46d-5be7-54ac-8060-6483b30d11f0","mechanism_event_label":"A second tissue showed a measured change.","subject":{"id":"34dfc4e7-fe01-57e7-ad40-a13564ee6507","slug":"ryr-icr-mouse-2005-preparation","display_name":"Red yeast rice preparation in the 2005 ICR mouse experiment","entity_type_key":"chemical_species"},"object":{"id":"e5101c60-e798-5b31-97b5-123e5a05879f","slug":"mouse-ryr-heart-coq10","display_name":"Mouse heart CoQ10 after acute red yeast rice gavage","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e245e46d-5be7-54ac-8060-6483b30d11f0","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-mouse-ryr-heart-coq-event","event_type":"observed_relationship","label":"A second tissue showed a measured change.","description":"The same acute mouse study reported lower cardiac CoQ10 after red yeast rice gavage, with greater suppression at the higher dose.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"34dfc4e7-fe01-57e7-ad40-a13564ee6507","slug":"ryr-icr-mouse-2005-preparation","display_name":"Red yeast rice preparation in the 2005 ICR mouse experiment","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e5101c60-e798-5b31-97b5-123e5a05879f","slug":"mouse-ryr-heart-coq10","display_name":"Mouse heart CoQ10 after acute red yeast rice gavage","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Male ICR mice, 1 or 5 g/kg oral gavage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The abstract repeats the heart label in its time-course description; precise tissue-specific onset is not reconstructed from that ambiguous wording.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A second tissue showed a measured change.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[15705235] Acute administration of red yeast rice (Monascus purpureus) depletes tissue coenzyme Q(10) levels in ICR mice. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15705235/ · DOI 10.1079/bjn20041285","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"6301d529-1626-592f-ba27-3846aa6c763f","evidence_kind":"source_excerpt","locator":"Lines 100-106","start_line":100,"end_line":106,"excerpt":"## red-yeast-rice-mouse-ryr-heart-coq\nA second tissue showed a measured change.\nThe same acute mouse study reported lower cardiac CoQ10 after red yeast rice gavage, with greater suppression at the higher dose.\nModel: Male ICR mice, 1 or 5 g/kg oral gavage.\nLimitations: The abstract repeats the heart label in its time-course description; precise tissue-specific onset is not reconstructed from that ambiguous wording.\nEvidence access: Primary abstract\n[15705235] Acute administration of red yeast rice (Monascus purpureus) depletes tissue coenzyme Q(10) levels in ICR mice. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15705235/ · DOI 10.1079/bjn20041285","model_system":"Male ICR mice, 1 or 5 g/kg oral gavage.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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