{"id":"e1bcfda4-c026-53fc-b797-28799df9b412","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-mouse-ryr-liver-coq","predicate":"reduces_tested","statement":"Acute red yeast rice gavage at 1 or 5 g/kg reduced hepatic CoQ10 in male ICR mice, with suppression still reported at 24 hours.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"721a43bf-4c95-592e-ae3a-302ce66fdef4","mechanism_event_label":"The mixture itself was tested in mice at high doses.","subject":{"id":"34dfc4e7-fe01-57e7-ad40-a13564ee6507","slug":"ryr-icr-mouse-2005-preparation","display_name":"Red yeast rice preparation in the 2005 ICR mouse experiment","entity_type_key":"chemical_species"},"object":{"id":"4a1ff50a-b6ba-57fe-a7ec-1887fa789562","slug":"mouse-ryr-liver-coq10","display_name":"Mouse liver CoQ10 after acute red yeast rice gavage","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"721a43bf-4c95-592e-ae3a-302ce66fdef4","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-mouse-ryr-liver-coq-event","event_type":"observed_relationship","label":"The mixture itself was tested in mice at high doses.","description":"Acute red yeast rice gavage at 1 or 5 g/kg reduced hepatic CoQ10 in male ICR mice, with suppression still reported at 24 hours.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"34dfc4e7-fe01-57e7-ad40-a13564ee6507","slug":"ryr-icr-mouse-2005-preparation","display_name":"Red yeast rice preparation in the 2005 ICR mouse experiment","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4a1ff50a-b6ba-57fe-a7ec-1887fa789562","slug":"mouse-ryr-liver-coq10","display_name":"Mouse liver CoQ10 after acute red yeast rice gavage","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Soybean-oil preparation; eight mice per experimental subgroup, sampled from 0.5 to 24 hours.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High-dose rodent exposure; the abstract describes controls killed immediately, so time and feeding controls limit interpretation. No human dose equivalence is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"The mixture itself was tested in mice at high doses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[15705235] Acute administration of red yeast rice (Monascus purpureus) depletes tissue coenzyme Q(10) levels in ICR mice. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15705235/ · DOI 10.1079/bjn20041285","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"46a744b4-c408-5832-b27a-588b6e4b6464","evidence_kind":"source_excerpt","locator":"Lines 92-98","start_line":92,"end_line":98,"excerpt":"## red-yeast-rice-mouse-ryr-liver-coq\nThe mixture itself was tested in mice at high doses.\nAcute red yeast rice gavage at 1 or 5 g/kg reduced hepatic CoQ10 in male ICR mice, with suppression still reported at 24 hours.\nModel: Soybean-oil preparation; eight mice per experimental subgroup, sampled from 0.5 to 24 hours.\nLimitations: High-dose rodent exposure; the abstract describes controls killed immediately, so time and feeding controls limit interpretation. No human dose equivalence is inferred.\nEvidence access: Primary abstract\n[15705235] Acute administration of red yeast rice (Monascus purpureus) depletes tissue coenzyme Q(10) levels in ICR mice. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15705235/ · DOI 10.1079/bjn20041285","model_system":"Soybean-oil preparation; eight mice per experimental subgroup, sampled from 0.5 to 24 hours.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"271bbcecaaacc76ad4d06718ae592dc6a1b33e3e459adfdd36cbd0ac5f09c0f6","revision_id":"9c30956c-206c-5c49-ae42-81b070088e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}