Component

RRR-alpha-tocopheryl acetate

Acetate ester of RRR-alpha-tocopherol; oral tracer vehicle in Traber 1990. Acetate ester of RRR-alpha-tocopherol used in defined zebrafish diets.

5 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. After equal oral labeled RRR- and SRR-alpha-tocopheryl acetate, the human chylomicron fraction contained similar concentrations of the two tocopherol stereoisomers.

    RRR-alpha-tocopherol → Chylomicron alpha-tocopherol stereoisomer delivery source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    experimental_model
    Human stable-isotope oral study with lipoprotein fractionation
    exposure
    Four subjects received equal paired doses of labeled RRR and SRR acetate ester with breakfast: 40, 50, 75 or 75 mg of each ester; samples through 76 hours.
    limitations
    Small tracer study; fraction enrichment alone does not prove the molecular sorting step or clinical benefit.
    nutrient_topic
    Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
    organism
    Homo sapiens
    plain_language
    Early chylomicron delivery did not strongly distinguish the two tested stereoisomers.
    primary_references
    [traber1990] RRR- and SRR-alpha-tocopherols are secreted without discrimination in human chylomicrons, but RRR-alpha-tocopherol is preferentially secreted in very low density lipoproteins. (1990). https://pubmed.ncbi.nlm.nih.gov/2351872/ DOI: 10.1016/s0022-2275(20)42836-6
    tissue_or_cell_type
    Plasma chylomicron or VLDL fractions

    Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 298–309

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human stable-isotope oral study with lipoprotein fractionation · source_derived_draft · unverified_draft

    ### ve-transport-chylomicron-stereoisomers After equal oral labeled RRR- and SRR-alpha-tocopheryl acetate, the human chylomicron fraction contained similar concentrations of the two tocopherol stereoisomers. Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: Early chylomicron delivery did not strongly distinguish the two tested stereoisomers. organism: Homo sapiens tissue_or_cell_type: Plasma chylomicron or VLDL fractions experimental_model: Human stable-isotope oral study with lipoprotein fractionation limitations: Small tracer study; fraction enrichment alone does not prove the molecular sorting step or clinical benefit. exposure: Four subjects received equal paired doses of labeled RRR and SRR acetate ester with breakfast: 40, 50, 75 or 75 mg of each ester; samples through 76 hours. cross_nutrient: false [traber1990] RRR- and SRR-alpha-tocopherols are secreted without discrimination in human chylomicrons, but RRR-alpha-tocopherol is preferentially secreted in very low density lipoproteins. (1990). https://pubmed.ncbi.nlm.nih.gov/2351872/ DOI: 10.1016/s0022-2275(20)42836-6
    Complete structured claim and evidence

  2. After equal oral labeled RRR- and SRR-alpha-tocopheryl acetate, human VLDL became enriched in RRR-alpha-tocopherol relative to SRR-alpha-tocopherol by 11 hours.

    RRR-alpha-tocopherol → VLDL alpha-tocopherol stereoisomer enrichment source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    experimental_model
    Human stable-isotope oral study with lipoprotein fractionation
    exposure
    Four subjects received equal paired doses of labeled RRR and SRR acetate ester with breakfast: 40, 50, 75 or 75 mg of each ester; samples through 76 hours.
    limitations
    Small tracer study; fraction enrichment alone does not prove the molecular sorting step or clinical benefit.
    nutrient_topic
    Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
    organism
    Homo sapiens
    plain_language
    A later lipoprotein fraction favored the RRR form.
    primary_references
    [traber1990] RRR- and SRR-alpha-tocopherols are secreted without discrimination in human chylomicrons, but RRR-alpha-tocopherol is preferentially secreted in very low density lipoproteins. (1990). https://pubmed.ncbi.nlm.nih.gov/2351872/ DOI: 10.1016/s0022-2275(20)42836-6
    tissue_or_cell_type
    Plasma chylomicron or VLDL fractions

    Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 311–322

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human stable-isotope oral study with lipoprotein fractionation · source_derived_draft · unverified_draft

    ### ve-transport-vldl-stereoisomers After equal oral labeled RRR- and SRR-alpha-tocopheryl acetate, human VLDL became enriched in RRR-alpha-tocopherol relative to SRR-alpha-tocopherol by 11 hours. Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: A later lipoprotein fraction favored the RRR form. organism: Homo sapiens tissue_or_cell_type: Plasma chylomicron or VLDL fractions experimental_model: Human stable-isotope oral study with lipoprotein fractionation limitations: Small tracer study; fraction enrichment alone does not prove the molecular sorting step or clinical benefit. exposure: Four subjects received equal paired doses of labeled RRR and SRR acetate ester with breakfast: 40, 50, 75 or 75 mg of each ester; samples through 76 hours. cross_nutrient: false [traber1990] RRR- and SRR-alpha-tocopherols are secreted without discrimination in human chylomicrons, but RRR-alpha-tocopherol is preferentially secreted in very low density lipoproteins. (1990). https://pubmed.ncbi.nlm.nih.gov/2351872/ DOI: 10.1016/s0022-2275(20)42836-6
    Complete structured claim and evidence

  3. After nine months on a diet without added vitamin E, zebrafish brain PC(16:0/22:6) was about one-third lower than in fish receiving 500 mg RRR-alpha-tocopheryl acetate/kg diet (4.3 versus 6.5 mg/g).

    Alpha-tocopherol → PC(16:0/22:6) source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    true
    evidence_location
    Primary abstract
    experimental_model
    Defined-diet comparison and brain lipidomics
    exposure
    9 months; no added E versus 500 mg RRR-alpha-tocopheryl acetate/kg.
    limitations
    Adult zebrafish dietary comparison; lipid abundance and oxidation product measurements do not by themselves prove causal remodeling flux or human neuroprotection.
    nutrient_topic
    Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
    organism
    Danio rerio
    plain_language
    Vitamin E depletion was associated with loss of a DHA-containing membrane lipid.
    primary_references
    [ver-choi2015] Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics. (2015). https://pubmed.ncbi.nlm.nih.gov/25855633/ DOI: 10.1194/jlr.m058941
    tissue_or_cell_type
    Adult brain
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 732–744

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Defined-diet comparison and brain lipidomics · source_derived_draft · unverified_draft

    ### ver-dha-pc-depletion After nine months on a diet without added vitamin E, zebrafish brain PC(16:0/22:6) was about one-third lower than in fish receiving 500 mg RRR-alpha-tocopheryl acetate/kg diet (4.3 versus 6.5 mg/g). Condition category: nutrient_deficiency nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: Vitamin E depletion was associated with loss of a DHA-containing membrane lipid. organism: Danio rerio tissue_or_cell_type: Adult brain experimental_model: Defined-diet comparison and brain lipidomics limitations: Adult zebrafish dietary comparison; lipid abundance and oxidation product measurements do not by themselves prove causal remodeling flux or human neuroprotection. exposure: 9 months; no added E versus 500 mg RRR-alpha-tocopheryl acetate/kg. cross_nutrient: true evidence_location: Primary abstract [ver-choi2015] Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics. (2015). https://pubmed.ncbi.nlm.nih.gov/25855633/ DOI: 10.1194/jlr.m058941
    Complete structured claim and evidence

  4. Vitamin E-depleted zebrafish brains contained more hydroxy-DHA-PC 38:6 than supplemented-diet controls, consistent with increased oxidation of DHA-containing phosphatidylcholine.

    Alpha-tocopherol → Hydroxy-DHA-PC 38:6 source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    true
    evidence_location
    Primary abstract
    experimental_model
    Defined-diet comparison and brain lipidomics
    exposure
    9 months; no added E versus 500 mg RRR-alpha-tocopheryl acetate/kg.
    limitations
    Adult zebrafish dietary comparison; lipid abundance and oxidation product measurements do not by themselves prove causal remodeling flux or human neuroprotection.
    nutrient_topic
    Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
    organism
    Danio rerio
    plain_language
    An oxidized DHA-containing lipid accumulated in the vitamin E-depleted brains.
    primary_references
    [ver-choi2015] Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics. (2015). https://pubmed.ncbi.nlm.nih.gov/25855633/ DOI: 10.1194/jlr.m058941
    tissue_or_cell_type
    Adult brain
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 746–758

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Defined-diet comparison and brain lipidomics · source_derived_draft · unverified_draft

    ### ver-dha-pc-oxidation Vitamin E-depleted zebrafish brains contained more hydroxy-DHA-PC 38:6 than supplemented-diet controls, consistent with increased oxidation of DHA-containing phosphatidylcholine. Condition category: nutrient_deficiency nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: An oxidized DHA-containing lipid accumulated in the vitamin E-depleted brains. organism: Danio rerio tissue_or_cell_type: Adult brain experimental_model: Defined-diet comparison and brain lipidomics limitations: Adult zebrafish dietary comparison; lipid abundance and oxidation product measurements do not by themselves prove causal remodeling flux or human neuroprotection. exposure: 9 months; no added E versus 500 mg RRR-alpha-tocopheryl acetate/kg. cross_nutrient: true evidence_location: Primary abstract [ver-choi2015] Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics. (2015). https://pubmed.ncbi.nlm.nih.gov/25855633/ DOI: 10.1194/jlr.m058941
    Complete structured claim and evidence

  5. Embryos from vitamin E-depleted zebrafish parents incorporated more water-18O label into LPC 22:6 and three DHA-containing phosphatidylcholines during 48–72 hours post-fertilization than vitamin E-sufficient controls, supporting increased acyl turnover.

    Alpha-tocopherol → DHA phospholipid remodeling source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    true
    evidence_location
    Figure 7; isotope-labeling Methods
    experimental_model
    Parental diet manipulation and stable-isotope lipidomics
    exposure
    Parents fed no added E or 500 mg RRR-alpha-tocopheryl acetate/kg for ≥80 days; embryos incubated in 40% H2(18)O from 48 to 72 hpf.
    limitations
    Embryos rely on maternally deposited nutrients; whole-embryo tracing does not directly measure brain delivery or prove a particular repair enzyme.
    nutrient_topic
    Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
    organism
    Danio rerio
    plain_language
    Labeled-water tracing showed faster turnover of selected DHA lipids during vitamin E depletion.
    primary_references
    [ver-mcdougall2016] Lipidomics and H2(18)O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos. (2016). https://pubmed.ncbi.nlm.nih.gov/26774753/ DOI: 10.1016/j.redox.2016.01.004
    tissue_or_cell_type
    Whole embryos
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 760–772

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Parental diet manipulation and stable-isotope lipidomics · source_derived_draft · unverified_draft

    ### ver-dha-remodeling-flux Embryos from vitamin E-depleted zebrafish parents incorporated more water-18O label into LPC 22:6 and three DHA-containing phosphatidylcholines during 48–72 hours post-fertilization than vitamin E-sufficient controls, supporting increased acyl turnover. Condition category: nutrient_deficiency nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: Labeled-water tracing showed faster turnover of selected DHA lipids during vitamin E depletion. organism: Danio rerio tissue_or_cell_type: Whole embryos experimental_model: Parental diet manipulation and stable-isotope lipidomics limitations: Embryos rely on maternally deposited nutrients; whole-embryo tracing does not directly measure brain delivery or prove a particular repair enzyme. exposure: Parents fed no added E or 500 mg RRR-alpha-tocopheryl acetate/kg for ≥80 days; embryos incubated in 40% H2(18)O from 48 to 72 hpf. cross_nutrient: true evidence_location: Figure 7; isotope-labeling Methods [ver-mcdougall2016] Lipidomics and H2(18)O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos. (2016). https://pubmed.ncbi.nlm.nih.gov/26774753/ DOI: 10.1016/j.redox.2016.01.004
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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