Component
Hydroxy-DHA-PC 38:6
Hydroxylated DHA-containing PC signal measured in zebrafish brains; exact oxidation position not asserted.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Vitamin E-depleted zebrafish brains contained more hydroxy-DHA-PC 38:6 than supplemented-diet controls, consistent with increased oxidation of DHA-containing phosphatidylcholine.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- true
- evidence_location
- Primary abstract
- experimental_model
- Defined-diet comparison and brain lipidomics
- exposure
- 9 months; no added E versus 500 mg RRR-alpha-tocopheryl acetate/kg.
- limitations
- Adult zebrafish dietary comparison; lipid abundance and oxidation product measurements do not by themselves prove causal remodeling flux or human neuroprotection.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Danio rerio
- plain_language
- An oxidized DHA-containing lipid accumulated in the vitamin E-depleted brains.
- primary_references
- [ver-choi2015] Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics. (2015). https://pubmed.ncbi.nlm.nih.gov/25855633/ DOI: 10.1194/jlr.m058941
- tissue_or_cell_type
- Adult brain
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 746–758
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Defined-diet comparison and brain lipidomics · source_derived_draft · unverified_draft
### ver-dha-pc-oxidation Vitamin E-depleted zebrafish brains contained more hydroxy-DHA-PC 38:6 than supplemented-diet controls, consistent with increased oxidation of DHA-containing phosphatidylcholine. Condition category: nutrient_deficiency nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: An oxidized DHA-containing lipid accumulated in the vitamin E-depleted brains. organism: Danio rerio tissue_or_cell_type: Adult brain experimental_model: Defined-diet comparison and brain lipidomics limitations: Adult zebrafish dietary comparison; lipid abundance and oxidation product measurements do not by themselves prove causal remodeling flux or human neuroprotection. exposure: 9 months; no added E versus 500 mg RRR-alpha-tocopheryl acetate/kg. cross_nutrient: true evidence_location: Primary abstract [ver-choi2015] Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics. (2015). https://pubmed.ncbi.nlm.nih.gov/25855633/ DOI: 10.1194/jlr.m058941
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.