Component

Rhesus foveal laser-induced blue-light damage susceptibility

Rhesus foveal laser-induced blue-light damage susceptibility. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Lutein or zeaxanthin supplementation restored foveal protection after deprivation.

    Lutein → Rhesus foveal laser-induced blue-light damage susceptibility source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/lutein-research/21245404.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b", "start_char": 0, "end_char": 1712, "text_sha256": "74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b"}
    experimental_model
    Dietary deprivation/repletion and controlled laser challenge
    exposure
    Eight lifelong xanthophyll-deprived animals, n-3 intake strata; 22–28 weeks L or Z; 476-nm exposures
    limitations
    Extreme animal depletion and laser injury are not a defined human deficiency syndrome or ordinary screen exposure.
    nutrient_topic
    Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
    organism
    Rhesus macaque
    plain_language
    Supplying a missing pigment improved this animal endpoint.
    primary_references
    [lutein-p21245404] Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage. (2011). https://pubmed.ncbi.nlm.nih.gov/21245404/ DOI: 10.1167/iovs.10-5898
    tissue_or_cell_type
    Foveal and parafoveal retina
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 450–461

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dietary deprivation/repletion and controlled laser challenge · source_derived_draft · unverified_draft

    ### lutein-deprivation-lutein-repletion Lutein or zeaxanthin supplementation restored foveal protection after deprivation. Condition category: nutrient_deficiency nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: Supplying a missing pigment improved this animal endpoint. organism: Rhesus macaque tissue_or_cell_type: Foveal and parafoveal retina experimental_model: Dietary deprivation/repletion and controlled laser challenge limitations: Extreme animal depletion and laser injury are not a defined human deficiency syndrome or ordinary screen exposure. exposure: Eight lifelong xanthophyll-deprived animals, n-3 intake strata; 22–28 weeks L or Z; 476-nm exposures evidence_span: {"source_cache": "artifacts/lutein-research/21245404.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b", "start_char": 0, "end_char": 1712, "text_sha256": "74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b"} [lutein-p21245404] Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage. (2011). https://pubmed.ncbi.nlm.nih.gov/21245404/ DOI: 10.1167/iovs.10-5898
    Complete structured claim and evidence

  2. The foveal protection observed in controls was absent in xanthophyll-free animals.

    Lifelong xanthophyll-free diet in rhesus monkeys → Rhesus foveal laser-induced blue-light damage susceptibility source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/lutein-research/21245404.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b", "start_char": 0, "end_char": 1712, "text_sha256": "74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b"}
    experimental_model
    Dietary deprivation/repletion and controlled laser challenge
    exposure
    Eight lifelong xanthophyll-deprived animals, n-3 intake strata; 22–28 weeks L or Z; 476-nm exposures
    limitations
    Extreme animal depletion and laser injury are not a defined human deficiency syndrome or ordinary screen exposure.
    nutrient_topic
    Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
    organism
    Rhesus macaque
    plain_language
    The central retina lost its relative protection in the challenge.
    primary_references
    [lutein-p21245404] Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage. (2011). https://pubmed.ncbi.nlm.nih.gov/21245404/ DOI: 10.1167/iovs.10-5898
    tissue_or_cell_type
    Foveal and parafoveal retina
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 437–448

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dietary deprivation/repletion and controlled laser challenge · source_derived_draft · unverified_draft

    ### lutein-deprivation-protection The foveal protection observed in controls was absent in xanthophyll-free animals. Condition category: nutrient_deficiency nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: The central retina lost its relative protection in the challenge. organism: Rhesus macaque tissue_or_cell_type: Foveal and parafoveal retina experimental_model: Dietary deprivation/repletion and controlled laser challenge limitations: Extreme animal depletion and laser injury are not a defined human deficiency syndrome or ordinary screen exposure. exposure: Eight lifelong xanthophyll-deprived animals, n-3 intake strata; 22–28 weeks L or Z; 476-nm exposures evidence_span: {"source_cache": "artifacts/lutein-research/21245404.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b", "start_char": 0, "end_char": 1712, "text_sha256": "74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b"} [lutein-p21245404] Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage. (2011). https://pubmed.ncbi.nlm.nih.gov/21245404/ DOI: 10.1167/iovs.10-5898
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards