{"id":"ec8035e1-89d7-552c-9afb-24a49d6e1586","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-deprivation-lutein-repletion","predicate":"restores_protection_against","statement":"Lutein or zeaxanthin supplementation restored foveal protection after deprivation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"01d0cf15-c452-519b-a385-c0ab16a6f613","mechanism_event_label":"Supplying a missing pigment improved this animal endpoint.","subject":{"id":"5dd84367-3f8e-5a3f-b952-a96174ea51fa","slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"},"object":{"id":"5224fb30-b858-52e1-b2fb-25629a7d8836","slug":"rhesus-foveal-photodamage","display_name":"Rhesus foveal laser-induced blue-light damage susceptibility","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"01d0cf15-c452-519b-a385-c0ab16a6f613","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-deprivation-lutein-repletion-event","event_type":"biochemical_relationship","label":"Supplying a missing pigment improved this animal endpoint.","description":"Lutein or zeaxanthin supplementation restored foveal protection after deprivation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5dd84367-3f8e-5a3f-b952-a96174ea51fa","slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5224fb30-b858-52e1-b2fb-25629a7d8836","slug":"rhesus-foveal-photodamage","display_name":"Rhesus foveal laser-induced blue-light damage susceptibility","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lutein-research/21245404.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b\", \"start_char\": 0, \"end_char\": 1712, \"text_sha256\": \"74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dietary deprivation/repletion and controlled laser challenge","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Eight lifelong xanthophyll-deprived animals, n-3 intake strata; 22–28 weeks L or Z; 476-nm exposures","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Extreme animal depletion and laser injury are not a defined human deficiency syndrome or ordinary screen exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lutein research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rhesus macaque","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Supplying a missing pigment improved this animal endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lutein-p21245404] Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage. (2011). https://pubmed.ncbi.nlm.nih.gov/21245404/ DOI: 10.1167/iovs.10-5898","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Foveal and parafoveal retina","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"bdfc3e42-c389-59fa-a49e-51337127e02b","evidence_kind":"source_excerpt","locator":"Lines 450-461","start_line":450,"end_line":461,"excerpt":"### lutein-deprivation-lutein-repletion\nLutein or zeaxanthin supplementation restored foveal protection after deprivation.\nCondition category: nutrient_deficiency\nnutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Supplying a missing pigment improved this animal endpoint.\norganism: Rhesus macaque\ntissue_or_cell_type: Foveal and parafoveal retina\nexperimental_model: Dietary deprivation/repletion and controlled laser challenge\nlimitations: Extreme animal depletion and laser injury are not a defined human deficiency syndrome or ordinary screen exposure.\nexposure: Eight lifelong xanthophyll-deprived animals, n-3 intake strata; 22–28 weeks L or Z; 476-nm exposures\nevidence_span: {\"source_cache\": \"artifacts/lutein-research/21245404.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b\", \"start_char\": 0, \"end_char\": 1712, \"text_sha256\": \"74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b\"}\n[lutein-p21245404] Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage. (2011). https://pubmed.ncbi.nlm.nih.gov/21245404/ DOI: 10.1167/iovs.10-5898","model_system":"Dietary deprivation/repletion and controlled laser challenge","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [lutein-p21245404] Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage. (2011). https://pubmed.ncbi.nlm.nih.gov/21245404/ DOI: 10.1167/iovs.10-5898","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"beef4241-6ebd-5b36-864c-6ef3ed7e61b8","stable_key":"import-cfa4bd86-d88d-555a-975c-68877bf00e0f","title":"Lutein: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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