Component

Chloride-dependent glycine response in rat Kupffer cells

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

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What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Chloride-free buffer abolished the reported glycine effect, and 1 micromolar strychnine reversed it; glycine hyperpolarized the tested Kupffer cells.

    Chloride ion → Chloride-dependent glycine response in rat Kupffer cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Rat immune-cell ion substitution and antagonist experiments.
    limitations
    Pharmacology does not uniquely identify a receptor-subunit combination; high-dose strychnine behaved differently.
    nutrient_topic
    Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Glycine
    plain_language
    The ionic environment was required for the observed response.
    primary_references
    Kupffer cells contain a glycine-gated chloride channel. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9227496/ · DOI 10.1152/ajpgi.1997.272.6.G1581

    Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19) · lines 338–344

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat immune-cell ion substitution and antagonist experiments. · source_derived_draft · unverified_draft

    ## glycine-kupffer-chloride-dependence The ionic environment was required for the observed response. Chloride-free buffer abolished the reported glycine effect, and 1 micromolar strychnine reversed it; glycine hyperpolarized the tested Kupffer cells. Model: Rat immune-cell ion substitution and antagonist experiments. Limitations: Pharmacology does not uniquely identify a receptor-subunit combination; high-dose strychnine behaved differently. Evidence access: Primary abstract Kupffer cells contain a glycine-gated chloride channel. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9227496/ · DOI 10.1152/ajpgi.1997.272.6.G1581
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Glycine at 1 mM nearly prevented the calcium rise elicited by 10 micrograms/mL LPS in cultured rat Kupffer cells.

    Glycine → LPS-evoked calcium rise in rat Kupffer cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Rat Kupffer-cell culture with glycine, LPS and receptor pharmacology.
    limitations
    High in-vitro exposure; not a demonstrated systemic anti-inflammatory effect in humans.
    nutrient_topic
    Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Glycine
    plain_language
    Glycine changed a calcium signal in liver immune cells.
    primary_references
    Kupffer cells contain a glycine-gated chloride channel. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9227496/ · DOI 10.1152/ajpgi.1997.272.6.G1581

    Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19) · lines 330–336

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat Kupffer-cell culture with glycine, LPS and receptor pharmacology. · source_derived_draft · unverified_draft

    ## glycine-kupffer-calcium Glycine changed a calcium signal in liver immune cells. Glycine at 1 mM nearly prevented the calcium rise elicited by 10 micrograms/mL LPS in cultured rat Kupffer cells. Model: Rat Kupffer-cell culture with glycine, LPS and receptor pharmacology. Limitations: High in-vitro exposure; not a demonstrated systemic anti-inflammatory effect in humans. Evidence access: Primary abstract Kupffer cells contain a glycine-gated chloride channel. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9227496/ · DOI 10.1152/ajpgi.1997.272.6.G1581
    Complete structured claim and evidence

  2. Glycine reduced LPS-associated TNF-alpha production in cultured rat Kupffer cells.

    Glycine → TNF-alpha output from LPS-stimulated rat Kupffer cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Rat cell-culture LPS challenge.
    limitations
    The cell assay does not establish a clinical effect or prove all intermediary steps.
    nutrient_topic
    Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Glycine
    plain_language
    A signaling change accompanied lower inflammatory-mediator output.
    primary_references
    Kupffer cells contain a glycine-gated chloride channel. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9227496/ · DOI 10.1152/ajpgi.1997.272.6.G1581

    Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19) · lines 346–352

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat cell-culture LPS challenge. · source_derived_draft · unverified_draft

    ## glycine-kupffer-tnf A signaling change accompanied lower inflammatory-mediator output. Glycine reduced LPS-associated TNF-alpha production in cultured rat Kupffer cells. Model: Rat cell-culture LPS challenge. Limitations: The cell assay does not establish a clinical effect or prove all intermediary steps. Evidence access: Primary abstract Kupffer cells contain a glycine-gated chloride channel. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9227496/ · DOI 10.1152/ajpgi.1997.272.6.G1581
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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