Component

Rat HMG-CoA reductase / Hmgcr

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Monacolin K acid sodium salt competitively inhibited rat liver HMG-CoA reductase with respect to HMG-CoA; the reported Ki was 0.49 nM.

    Monacolin K hydroxy-acid sodium salt → Rat HMG-CoA reductase / Hmgcr source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary PDF, p335 and Figure 3 visually inspected
    experimental_model
    Partially purified rat liver microsomal reductase; radiolabeled product assay.
    limitations
    Assay-specific inhibition constant, not a human plasma threshold or potency of an entire rice product.
    nutrient_topic
    Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
    plain_language
    The active preparation competed with the enzyme substrate.
    primary_references
    [7380744] Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. · 1980 · https://pubmed.ncbi.nlm.nih.gov/7380744/ · DOI 10.7164/antibiotics.33.334

    Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 52–58

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Partially purified rat liver microsomal reductase; radiolabeled product assay. · source_derived_draft · unverified_draft

    ## red-yeast-rice-hmgcr-binding The active preparation competed with the enzyme substrate. Monacolin K acid sodium salt competitively inhibited rat liver HMG-CoA reductase with respect to HMG-CoA; the reported Ki was 0.49 nM. Model: Partially purified rat liver microsomal reductase; radiolabeled product assay. Limitations: Assay-specific inhibition constant, not a human plasma threshold or potency of an entire rice product. Evidence access: Primary PDF, p335 and Figure 3 visually inspected [7380744] Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. · 1980 · https://pubmed.ncbi.nlm.nih.gov/7380744/ · DOI 10.7164/antibiotics.33.334
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Monacolin K inhibited lipid labeling from acetate or HMG-CoA, but did not inhibit incorporation from supplied mevalonate at concentrations up to 10 mM.

    Lovastatin / monacolin K lactone → Mevalonate source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary PDF, p335 visually inspected
    experimental_model
    Rat liver cell-free nonsaponifiable-lipid synthesis; lactone and acid preparations tested.
    limitations
    A biochemical bypass is not a clinical repletion strategy; the 10 mM figure applies to tested monacolin concentrations, not human exposure.
    nutrient_topic
    Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
    plain_language
    Supplying the downstream intermediate bypassed the inhibited step in this assay.
    primary_references
    [7380744] Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. · 1980 · https://pubmed.ncbi.nlm.nih.gov/7380744/ · DOI 10.7164/antibiotics.33.334

    Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 68–74

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat liver cell-free nonsaponifiable-lipid synthesis; lactone and acid preparations tested. · source_derived_draft · unverified_draft

    ## red-yeast-rice-mevalonate-bypass Supplying the downstream intermediate bypassed the inhibited step in this assay. Monacolin K inhibited lipid labeling from acetate or HMG-CoA, but did not inhibit incorporation from supplied mevalonate at concentrations up to 10 mM. Model: Rat liver cell-free nonsaponifiable-lipid synthesis; lactone and acid preparations tested. Limitations: A biochemical bypass is not a clinical repletion strategy; the 10 mM figure applies to tested monacolin concentrations, not human exposure. Evidence access: Primary PDF, p335 visually inspected [7380744] Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. · 1980 · https://pubmed.ncbi.nlm.nih.gov/7380744/ · DOI 10.7164/antibiotics.33.334
    Complete structured claim and evidence

  2. The same monacolin K inhibition was noncompetitive with respect to NADPH.

    Monacolin K hydroxy-acid sodium salt → NADPH source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary PDF, p335 visually inspected
    experimental_model
    Rat liver reductase kinetics in the 1980 study.
    limitations
    Not evidence of NADPH depletion, niacin deficiency or reversal by niacin supplementation.
    nutrient_topic
    Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
    plain_language
    The reducing cofactor and the competing substrate have different roles.
    primary_references
    [7380744] Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. · 1980 · https://pubmed.ncbi.nlm.nih.gov/7380744/ · DOI 10.7164/antibiotics.33.334

    Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 60–66

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat liver reductase kinetics in the 1980 study. · source_derived_draft · unverified_draft

    ## red-yeast-rice-nadph-noncompetition The reducing cofactor and the competing substrate have different roles. The same monacolin K inhibition was noncompetitive with respect to NADPH. Model: Rat liver reductase kinetics in the 1980 study. Limitations: Not evidence of NADPH depletion, niacin deficiency or reversal by niacin supplementation. Evidence access: Primary PDF, p335 visually inspected [7380744] Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. · 1980 · https://pubmed.ncbi.nlm.nih.gov/7380744/ · DOI 10.7164/antibiotics.33.334
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards