{"id":"f5318b14-37ff-52a8-97bd-6e9b253e7842","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-mevalonate-bypass","predicate":"does_not_block_tested_downstream_use_of","statement":"Monacolin K inhibited lipid labeling from acetate or HMG-CoA, but did not inhibit incorporation from supplied mevalonate at concentrations up to 10 mM.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"2c19db69-7cd5-5c45-8e53-857eed458201","mechanism_event_label":"Supplying the downstream intermediate bypassed the inhibited step in this assay.","subject":{"id":"5d0ea9bb-cce8-5e13-aa3d-37db2215386e","slug":"lovastatin","display_name":"Lovastatin / monacolin K lactone","entity_type_key":"drug"},"object":{"id":"3df322fd-ac21-5bd1-aa46-4af1ec708b57","slug":"mevalonate","display_name":"Mevalonate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"2c19db69-7cd5-5c45-8e53-857eed458201","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-mevalonate-bypass-event","event_type":"observed_relationship","label":"Supplying the downstream intermediate bypassed the inhibited step in this assay.","description":"Monacolin K inhibited lipid labeling from acetate or HMG-CoA, but did not inhibit incorporation from supplied mevalonate at concentrations up to 10 mM.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5d0ea9bb-cce8-5e13-aa3d-37db2215386e","slug":"lovastatin","display_name":"Lovastatin / monacolin K lactone","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3df322fd-ac21-5bd1-aa46-4af1ec708b57","slug":"mevalonate","display_name":"Mevalonate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bd3bb602-9a12-5d58-8130-538236270e6f","slug":"lovastatin-acid","display_name":"Lovastatin hydroxy acid / monacolin KA","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"49a9fd79-4ebe-5c77-ad3a-a026d354b753","slug":"rat-hmgcr","display_name":"Rat HMG-CoA reductase / Hmgcr","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary PDF, p335 visually inspected","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat liver cell-free nonsaponifiable-lipid synthesis; lactone and acid preparations tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A biochemical bypass is not a clinical repletion strategy; the 10 mM figure applies to tested monacolin concentrations, not human exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Supplying the downstream intermediate bypassed the inhibited step in this assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[7380744] Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. · 1980 · https://pubmed.ncbi.nlm.nih.gov/7380744/ · DOI 10.7164/antibiotics.33.334","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"57cce37d-6ee9-5a09-8c9b-852c611a14f1","evidence_kind":"source_excerpt","locator":"Lines 68-74","start_line":68,"end_line":74,"excerpt":"## red-yeast-rice-mevalonate-bypass\nSupplying the downstream intermediate bypassed the inhibited step in this assay.\nMonacolin K inhibited lipid labeling from acetate or HMG-CoA, but did not inhibit incorporation from supplied mevalonate at concentrations up to 10 mM.\nModel: Rat liver cell-free nonsaponifiable-lipid synthesis; lactone and acid preparations tested.\nLimitations: A biochemical bypass is not a clinical repletion strategy; the 10 mM figure applies to tested monacolin concentrations, not human exposure.\nEvidence access: Primary PDF, p335 visually inspected\n[7380744] Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. · 1980 · https://pubmed.ncbi.nlm.nih.gov/7380744/ · DOI 10.7164/antibiotics.33.334","model_system":"Rat liver cell-free nonsaponifiable-lipid synthesis; lactone and acid preparations tested.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"271bbcecaaacc76ad4d06718ae592dc6a1b33e3e459adfdd36cbd0ac5f09c0f6","revision_id":"9c30956c-206c-5c49-ae42-81b070088e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}