Component
Rabbit renal brush-border pantothenate uptake
Rabbit renal brush-border pantothenate uptake. Experimental context and limitations are specified in the linked claims.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
An inside-negative membrane potential drove uphill pantothenate accumulation in rabbit renal brush-border vesicles when sodium was present even without a sodium concentration gradient.
Experimental context and source evidence
- cross_nutrient
- true
- experimental_model
- Isolated rabbit renal brush-border membrane vesicles with controlled ion gradients and membrane potentials
- exposure
- Inside-negative membrane potential imposed with sodium present but no transmembrane sodium gradient.
- limitations
- Rabbit isolated-membrane experiment; this predates molecular identification of SMVT and does not independently assign the effect to human SLC5A6 or establish a human renal clearance threshold.
- nutrient_topic
- Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
- organism
- Oryctolagus cuniculus
- plain_language
- Electrical potential also helps power renal pantothenate uptake.
- primary_references
- [b5-trans-renal1986] Pantothenate-sodium cotransport in renal brush-border membranes. (1986). https://pubmed.ncbi.nlm.nih.gov/3771539/ DOI: 10.1016/s0021-9258(18)66891-7
- tissue_or_cell_type
- Renal brush-border membrane vesicles
Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 249–260
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Isolated rabbit renal brush-border membrane vesicles with controlled ion gradients and membrane potentials · source_derived_draft · unverified_draft
### b5-trans-renal-membrane-potential An inside-negative membrane potential drove uphill pantothenate accumulation in rabbit renal brush-border vesicles when sodium was present even without a sodium concentration gradient. Condition category: normal nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Electrical potential also helps power renal pantothenate uptake. organism: Oryctolagus cuniculus tissue_or_cell_type: Renal brush-border membrane vesicles experimental_model: Isolated rabbit renal brush-border membrane vesicles with controlled ion gradients and membrane potentials limitations: Rabbit isolated-membrane experiment; this predates molecular identification of SMVT and does not independently assign the effect to human SLC5A6 or establish a human renal clearance threshold. exposure: Inside-negative membrane potential imposed with sodium present but no transmembrane sodium gradient. cross_nutrient: true [b5-trans-renal1986] Pantothenate-sodium cotransport in renal brush-border membranes. (1986). https://pubmed.ncbi.nlm.nih.gov/3771539/ DOI: 10.1016/s0021-9258(18)66891-7
Complete structured claim and evidenceAn inward sodium gradient drove transient pantothenate accumulation against its concentration gradient in voltage-clamped rabbit renal brush-border vesicles.
Experimental context and source evidence
- cross_nutrient
- true
- experimental_model
- Isolated rabbit renal brush-border membrane vesicles with controlled ion gradients and membrane potentials
- exposure
- Inward NaCl gradient under voltage clamp; potassium, rubidium, lithium, ammonium and choline could not substitute for sodium.
- limitations
- Rabbit isolated-membrane experiment; this predates molecular identification of SMVT and does not independently assign the effect to human SLC5A6 or establish a human renal clearance threshold.
- nutrient_topic
- Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
- organism
- Oryctolagus cuniculus
- plain_language
- Sodium provides energy for pantothenate uptake at the rabbit kidney brush border.
- primary_references
- [b5-trans-renal1986] Pantothenate-sodium cotransport in renal brush-border membranes. (1986). https://pubmed.ncbi.nlm.nih.gov/3771539/ DOI: 10.1016/s0021-9258(18)66891-7
- tissue_or_cell_type
- Renal brush-border membrane vesicles
Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 236–247
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Isolated rabbit renal brush-border membrane vesicles with controlled ion gradients and membrane potentials · source_derived_draft · unverified_draft
### b5-trans-renal-sodium-gradient An inward sodium gradient drove transient pantothenate accumulation against its concentration gradient in voltage-clamped rabbit renal brush-border vesicles. Condition category: normal nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Sodium provides energy for pantothenate uptake at the rabbit kidney brush border. organism: Oryctolagus cuniculus tissue_or_cell_type: Renal brush-border membrane vesicles experimental_model: Isolated rabbit renal brush-border membrane vesicles with controlled ion gradients and membrane potentials limitations: Rabbit isolated-membrane experiment; this predates molecular identification of SMVT and does not independently assign the effect to human SLC5A6 or establish a human renal clearance threshold. exposure: Inward NaCl gradient under voltage clamp; potassium, rubidium, lithium, ammonium and choline could not substitute for sodium. cross_nutrient: true [b5-trans-renal1986] Pantothenate-sodium cotransport in renal brush-border membranes. (1986). https://pubmed.ncbi.nlm.nih.gov/3771539/ DOI: 10.1016/s0021-9258(18)66891-7
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.