Component
Preeclampsia incidence
Process or measured study endpoint, not a chemical species; outcome definition is retained in claim context.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The 500-mg calcium regimen met the prespecified noninferiority criterion versus 1500 mg for preeclampsia in both 2024 trials.
Experimental context and source evidence
- experimental_model
- Independent India and Tanzania trials; 11,000 nulliparous women each.
- exposure
- 500 versus 1500 mg elemental calcium/day; preeclampsia RR noninferiority margin 1.54.
- limitations
- No placebo arm: this cannot establish benefit versus no supplement. Noninferiority is not exact equality or a dosing recommendation.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens
- plain_language
- The lower tested dose performed within the trial margin relative to the higher dose.
- primary_references
- [cal-clin-dwarkanath2024] Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy (2024). https://www.nejm.org/doi/full/10.1056/NEJMoa2307212 DOI: 10.1056/NEJMoa2307212
- tissue_or_cell_type
- Human clinical or absorption endpoint
Calcium: mechanism-first literature curation (2026-09-17) · lines 1353–1363
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Independent India and Tanzania trials; 11,000 nulliparous women each. · source_derived_draft · unverified_draft
### cal-pregnancy-dose-noninferiority The 500-mg calcium regimen met the prespecified noninferiority criterion versus 1500 mg for preeclampsia in both 2024 trials. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The lower tested dose performed within the trial margin relative to the higher dose. organism: Homo sapiens tissue_or_cell_type: Human clinical or absorption endpoint experimental_model: Independent India and Tanzania trials; 11,000 nulliparous women each. limitations: No placebo arm: this cannot establish benefit versus no supplement. Noninferiority is not exact equality or a dosing recommendation. exposure: 500 versus 1500 mg elemental calcium/day; preeclampsia RR noninferiority margin 1.54. [cal-clin-dwarkanath2024] Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy (2024). https://www.nejm.org/doi/full/10.1056/NEJMoa2307212 DOI: 10.1056/NEJMoa2307212
Complete structured claim and evidenceIn the WHO low-intake pregnancy trial, calcium did not significantly reduce overall preeclampsia incidence.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- experimental_model
- 8325 nulliparous women; blinded placebo comparison.
- exposure
- 1.5 g calcium/day starting before 20 weeks; preeclampsia 4.1% versus 4.5%.
- limitations
- Preeclampsia was primary; reported benefits on severe outcomes were secondary.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens
- plain_language
- Low baseline intake did not guarantee a benefit on the primary pregnancy outcome.
- primary_references
- [cal-clin-villar2006] World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant women (2006). https://pubmed.ncbi.nlm.nih.gov/16522392/ DOI: 10.1016/j.ajog.2006.01.068
- tissue_or_cell_type
- Human clinical or absorption endpoint
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Calcium: mechanism-first literature curation (2026-09-17) · lines 1329–1339
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 8325 nulliparous women; blinded placebo comparison. · source_derived_draft · unverified_draft
### cal-who-preeclampsia In the WHO low-intake pregnancy trial, calcium did not significantly reduce overall preeclampsia incidence. Condition category: nutrient_deficiency nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Low baseline intake did not guarantee a benefit on the primary pregnancy outcome. organism: Homo sapiens tissue_or_cell_type: Human clinical or absorption endpoint experimental_model: 8325 nulliparous women; blinded placebo comparison. limitations: Preeclampsia was primary; reported benefits on severe outcomes were secondary. exposure: 1.5 g calcium/day starting before 20 weeks; preeclampsia 4.1% versus 4.5%. [cal-clin-villar2006] World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant women (2006). https://pubmed.ncbi.nlm.nih.gov/16522392/ DOI: 10.1016/j.ajog.2006.01.068
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.