{"id":"29c5e405-aac5-5a28-ab75-58f6060aedeb","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:cal-pregnancy-dose-noninferiority","predicate":"has_reported_effect_on","statement":"The 500-mg calcium regimen met the prespecified noninferiority criterion versus 1500 mg for preeclampsia in both 2024 trials.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"afcfa5e8-0451-5584-bae6-ef0e76c94217","mechanism_event_label":"The lower tested dose performed within the trial margin relative to the higher dose.","subject":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"object":{"id":"8d47d94b-348c-5f12-a72b-3eb3e986dcbc","slug":"preeclampsia-incidence","display_name":"Preeclampsia incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"afcfa5e8-0451-5584-bae6-ef0e76c94217","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:cal-pregnancy-dose-noninferiority-event","event_type":"observed_intervention","label":"The lower tested dose performed within the trial margin relative to the higher dose.","description":"The 500-mg calcium regimen met the prespecified noninferiority criterion versus 1500 mg for preeclampsia in both 2024 trials.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"tested_input","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8d47d94b-348c-5f12-a72b-3eb3e986dcbc","slug":"preeclampsia-incidence","display_name":"Preeclampsia incidence","entity_type_key":"cellular_process"},"role":"measured_outcome","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Independent India and Tanzania trials; 11,000 nulliparous women each.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"500 versus 1500 mg elemental calcium/day; preeclampsia RR noninferiority margin 1.54.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No placebo arm: this cannot establish benefit versus no supplement. Noninferiority is not exact equality or a dosing recommendation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The lower tested dose performed within the trial margin relative to the higher dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cal-clin-dwarkanath2024] Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy (2024). https://www.nejm.org/doi/full/10.1056/NEJMoa2307212 DOI: 10.1056/NEJMoa2307212","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human clinical or absorption endpoint","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"026f14b5-58be-5e03-8d94-fb62c5821486","evidence_kind":"source_excerpt","locator":"Lines 1353-1363","start_line":1353,"end_line":1363,"excerpt":"### cal-pregnancy-dose-noninferiority\nThe 500-mg calcium regimen met the prespecified noninferiority criterion versus 1500 mg for preeclampsia in both 2024 trials.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The lower tested dose performed within the trial margin relative to the higher dose.\norganism: Homo sapiens\ntissue_or_cell_type: Human clinical or absorption endpoint\nexperimental_model: Independent India and Tanzania trials; 11,000 nulliparous women each.\nlimitations: No placebo arm: this cannot establish benefit versus no supplement. Noninferiority is not exact equality or a dosing recommendation.\nexposure: 500 versus 1500 mg elemental calcium/day; preeclampsia RR noninferiority margin 1.54.\n[cal-clin-dwarkanath2024] Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy (2024). https://www.nejm.org/doi/full/10.1056/NEJMoa2307212 DOI: 10.1056/NEJMoa2307212","model_system":"Independent India and Tanzania trials; 11,000 nulliparous women each.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cal-clin-dwarkanath2024] Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy (2024). https://www.nejm.org/doi/full/10.1056/NEJMoa2307212 DOI: 10.1056/NEJMoa2307212","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}