{"id":"68e49a4f-b46f-561f-b49a-1675c226600e","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:cal-who-preeclampsia","predicate":"has_reported_effect_on","statement":"In the WHO low-intake pregnancy trial, calcium did not significantly reduce overall preeclampsia incidence.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"95ad259a-c267-5432-816b-ffcd943ee1c7","mechanism_event_label":"Low baseline intake did not guarantee a benefit on the primary pregnancy outcome.","subject":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"object":{"id":"8d47d94b-348c-5f12-a72b-3eb3e986dcbc","slug":"preeclampsia-incidence","display_name":"Preeclampsia incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"95ad259a-c267-5432-816b-ffcd943ee1c7","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:cal-who-preeclampsia-event","event_type":"observed_intervention","label":"Low baseline intake did not guarantee a benefit on the primary pregnancy outcome.","description":"In the WHO low-intake pregnancy trial, calcium did not significantly reduce overall preeclampsia incidence.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"tested_input","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8d47d94b-348c-5f12-a72b-3eb3e986dcbc","slug":"preeclampsia-incidence","display_name":"Preeclampsia incidence","entity_type_key":"cellular_process"},"role":"measured_outcome","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"8325 nulliparous women; blinded placebo comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"1.5 g calcium/day starting before 20 weeks; preeclampsia 4.1% versus 4.5%.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preeclampsia was primary; reported benefits on severe outcomes were secondary.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Low baseline intake did not guarantee a benefit on the primary pregnancy outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cal-clin-villar2006] World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant women (2006). https://pubmed.ncbi.nlm.nih.gov/16522392/ DOI: 10.1016/j.ajog.2006.01.068","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human clinical or absorption endpoint","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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blinded placebo comparison.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cal-clin-villar2006] World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant women (2006). https://pubmed.ncbi.nlm.nih.gov/16522392/ DOI: 10.1016/j.ajog.2006.01.068","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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Reporting only the secondary result would overstate the trial conclusion.","resolution":"Unresolved; needs review.","created_at":"2026-09-17 08:08:54","record_type":"conflict","display_label":"Recorded conflict","record_url":"/conflicts/e6e92509-dbee-5e9e-88f4-fc2b38bcb63f","sides":[{"conflict_id":"e6e92509-dbee-5e9e-88f4-fc2b38bcb63f","ordinal":0,"label":"Low baseline intake did not guarantee a benefit on the primary pregnancy outcome.","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","start_line":1329,"end_line":1339,"quote":"### cal-who-preeclampsia\nIn the WHO low-intake pregnancy trial, calcium did not significantly reduce overall preeclampsia incidence.\nCondition category: nutrient_deficiency\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Low baseline intake did not guarantee a benefit on the primary pregnancy outcome.\norganism: Homo sapiens\ntissue_or_cell_type: Human clinical or absorption endpoint\nexperimental_model: 8325 nulliparous women; blinded placebo comparison.\nlimitations: Preeclampsia was primary; reported benefits on severe outcomes were secondary.\nexposure: 1.5 g calcium/day starting before 20 weeks; preeclampsia 4.1% versus 4.5%.\n[cal-clin-villar2006] World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant women (2006). https://pubmed.ncbi.nlm.nih.gov/16522392/ DOI: 10.1016/j.ajog.2006.01.068","source_key":"import-434e1e27-eb90-583a-956b-62472726ffba","source_title":"Calcium: mechanism-first literature curation (2026-09-17)","claim_ids":["68e49a4f-b46f-561f-b49a-1675c226600e"]},{"conflict_id":"e6e92509-dbee-5e9e-88f4-fc2b38bcb63f","ordinal":1,"label":"A severe secondary outcome improved despite the null primary result.","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","start_line":1341,"end_line":1351,"quote":"### cal-who-eclampsia\nEclampsia was less frequent with calcium in a secondary analysis of the same WHO trial.\nCondition category: nutrient_deficiency\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A severe secondary outcome improved despite the null primary result.\norganism: Homo sapiens\ntissue_or_cell_type: Human clinical or absorption endpoint\nexperimental_model: Same randomized pregnancy trial.\nlimitations: Secondary endpoint; distinct from preeclampsia incidence and not proof of an identified molecular mediator.\nexposure: Eclampsia RR 0.68, 95% CI 0.48-0.97.\n[cal-clin-villar2006] World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant women (2006). https://pubmed.ncbi.nlm.nih.gov/16522392/ DOI: 10.1016/j.ajog.2006.01.068","source_key":"import-434e1e27-eb90-583a-956b-62472726ffba","source_title":"Calcium: mechanism-first literature curation (2026-09-17)","claim_ids":["61967c3b-c7c6-5c62-8c54-dff4cfeaa961"]}]}],"corrections":[],"research":null}