Component
Potassium balance
Measured potassium input minus output over a stated interval; methods and included output routes must be specified.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Randomized additional Mg sulfate improved 48-hour potassium input-minus-urine balance in hypokalemic ICU adults despite similar serum K; between-group total potassium replacement was not significantly different.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- cross_nutrient
- magnesium -> potassium
- experimental_model
- Double-blind placebo-controlled randomized surgical-ICU trial
- limitations
- Usual K/Mg treatment continued in both groups; 30 completers; hypokalemia enrollment did not establish intracellular Mg depletion in every patient.
- nutrient_topic
- Magnesium research collection; topical membership is not evidence of a direct dietary effect. · Magnesium
- organism
- Homo sapiens
- plain_language
- The Mg group retained more of the potassium supplied even though blood potassium looked similar. This supports retention, not a directly proven human ROMK mechanism.
- primary_references
- [hamill-ruth-1996-potassium-balance] Magnesium repletion and its effect on potassium homeostasis in critically ill adults: results of a double-blind, randomized, controlled trial. (1996). https://pubmed.ncbi.nlm.nih.gov/8565536/ DOI: 10.1097/00003246-199601000-00009
- tissue_or_cell_type
- Blood and timed urine collections
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 241–251
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind placebo-controlled randomized surgical-ICU trial · source_derived_draft · unverified_draft
### icu-mg-repletion-improves-potassium-balance Randomized additional Mg sulfate improved 48-hour potassium input-minus-urine balance in hypokalemic ICU adults despite similar serum K; between-group total potassium replacement was not significantly different. Condition category: biomarker_context nutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The Mg group retained more of the potassium supplied even though blood potassium looked similar. This supports retention, not a directly proven human ROMK mechanism. organism: Homo sapiens tissue_or_cell_type: Blood and timed urine collections experimental_model: Double-blind placebo-controlled randomized surgical-ICU trial limitations: Usual K/Mg treatment continued in both groups; 30 completers; hypokalemia enrollment did not establish intracellular Mg depletion in every patient. cross_nutrient: magnesium -> potassium [hamill-ruth-1996-potassium-balance] Magnesium repletion and its effect on potassium homeostasis in critically ill adults: results of a double-blind, randomized, controlled trial. (1996). https://pubmed.ncbi.nlm.nih.gov/8565536/ DOI: 10.1097/00003246-199601000-00009
Complete structured claim and evidence
Where it participates (unsigned role)
Prolonged experimental Mg depletion caused hypokalemia requiring substantial extra potassium intake to maintain serum K, alongside decreased exchangeable potassium.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- magnesium -> potassium
- experimental_model
- Within-person dietary depletion and repletion
- limitations
- Two elderly men; no native human channel assay and no causal localization of potassium loss to ROMK.
- nutrient_topic
- Magnesium research collection; topical membership is not evidence of a direct dietary effect. · Magnesium
- organism
- Homo sapiens
- plain_language
- Supplying potassium became less effective at maintaining potassium status as Mg depletion progressed.
- primary_references
- [shils-1964-human-depletion] Experimental Human Magnesium Depletion. I. Clinical Observations and Blood Chemistry Alterations (1964). https://pubmed.ncbi.nlm.nih.gov/14212747/ DOI: 10.1093/ajcn/15.3.133
- tissue_or_cell_type
- Blood and whole-body potassium pool
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 217–227
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Within-person dietary depletion and repletion · source_derived_draft · unverified_draft
### human-mg-depletion-increases-k-replacement-needs Prolonged experimental Mg depletion caused hypokalemia requiring substantial extra potassium intake to maintain serum K, alongside decreased exchangeable potassium. Condition category: nutrient_deficiency nutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Supplying potassium became less effective at maintaining potassium status as Mg depletion progressed. organism: Homo sapiens tissue_or_cell_type: Blood and whole-body potassium pool experimental_model: Within-person dietary depletion and repletion limitations: Two elderly men; no native human channel assay and no causal localization of potassium loss to ROMK. cross_nutrient: magnesium -> potassium [shils-1964-human-depletion] Experimental Human Magnesium Depletion. I. Clinical Observations and Blood Chemistry Alterations (1964). https://pubmed.ncbi.nlm.nih.gov/14212747/ DOI: 10.1093/ajcn/15.3.133
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.