{"id":"e93131d6-b6e1-55e9-9556-4209c78d1fb4","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:icu-mg-repletion-improves-potassium-balance","predicate":"treatment-improves","statement":"Randomized additional Mg sulfate improved 48-hour potassium input-minus-urine balance in hypokalemic ICU adults despite similar serum K; between-group total potassium replacement was not significantly different.","claim_class":"correction","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"4cf9da71-20fd-54a7-ade2-0a29f96f7656","mechanism_event_label":"The Mg group retained more of the potassium supplied even though blood potassium looked similar. 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This supports retention, not a directly proven human ROMK mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[hamill-ruth-1996-potassium-balance] Magnesium repletion and its effect on potassium homeostasis in critically ill adults: results of a double-blind, randomized, controlled trial. (1996). https://pubmed.ncbi.nlm.nih.gov/8565536/ DOI: 10.1097/00003246-199601000-00009","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood and timed urine collections","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"1efed43e-7643-5f70-b03b-a5dfe5ca4434","evidence_kind":"source_excerpt","locator":"Lines 241-251","start_line":241,"end_line":251,"excerpt":"### icu-mg-repletion-improves-potassium-balance\nRandomized additional Mg sulfate improved 48-hour potassium input-minus-urine balance in hypokalemic ICU adults despite similar serum K; between-group total potassium replacement was not significantly different.\nCondition category: biomarker_context\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The Mg group retained more of the potassium supplied even though blood potassium looked similar. This supports retention, not a directly proven human ROMK mechanism.\norganism: Homo sapiens\ntissue_or_cell_type: Blood and timed urine collections\nexperimental_model: Double-blind placebo-controlled randomized surgical-ICU trial\nlimitations: Usual K/Mg treatment continued in both groups; 30 completers; hypokalemia enrollment did not establish intracellular Mg depletion in every patient.\ncross_nutrient: magnesium -> potassium\n[hamill-ruth-1996-potassium-balance] Magnesium repletion and its effect on potassium homeostasis in critically ill adults: results of a double-blind, randomized, controlled trial. (1996). https://pubmed.ncbi.nlm.nih.gov/8565536/ DOI: 10.1097/00003246-199601000-00009","model_system":"Double-blind placebo-controlled randomized surgical-ICU trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [hamill-ruth-1996-potassium-balance] Magnesium repletion and its effect on potassium homeostasis in critically ill adults: results of a double-blind, randomized, controlled trial. (1996). https://pubmed.ncbi.nlm.nih.gov/8565536/ DOI: 10.1097/00003246-199601000-00009","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}