{"id":"44b72c83-1588-57f1-8b8d-372892fe7661","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:human-mg-depletion-increases-k-replacement-needs","predicate":"depletion-impairs-maintenance-of","statement":"Prolonged experimental Mg depletion caused hypokalemia requiring substantial extra potassium intake to maintain serum K, alongside decreased exchangeable potassium.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"73f7f88c-2348-50bc-bdfe-22c0d39d66f3","mechanism_event_label":"Supplying potassium became less effective at maintaining potassium status as Mg depletion progressed.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"evidence_count":1,"mechanism_event":{"id":"73f7f88c-2348-50bc-bdfe-22c0d39d66f3","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:human-mg-depletion-increases-k-replacement-needs-event","event_type":"biochemical_relationship","label":"Supplying potassium became less effective at maintaining potassium status as Mg depletion progressed.","description":"Prolonged experimental Mg depletion caused hypokalemia requiring substantial extra potassium intake to maintain serum K, alongside decreased exchangeable potassium.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"91de6063-d0ae-5f4c-9935-75bcec18c7b5","slug":"serum-potassium-concentration","display_name":"Serum or plasma potassium concentration","entity_type_key":"cellular_process"},"role":"circulating endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1318398b-2085-5237-a14a-b443e1b47fdd","slug":"potassium-balance","display_name":"Potassium balance","entity_type_key":"cellular_process"},"role":"body-pool context","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"magnesium -> potassium","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Within-person dietary depletion and repletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Two elderly men; no native human channel assay and no causal localization of potassium loss to ROMK.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Supplying potassium became less effective at maintaining potassium status as Mg depletion progressed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[shils-1964-human-depletion] Experimental Human Magnesium Depletion. I. Clinical Observations and Blood Chemistry Alterations (1964). https://pubmed.ncbi.nlm.nih.gov/14212747/ DOI: 10.1093/ajcn/15.3.133","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood and whole-body potassium pool","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"712bb146-64df-5e29-baaf-306b83ea20f1","evidence_kind":"source_excerpt","locator":"Lines 217-227","start_line":217,"end_line":227,"excerpt":"### human-mg-depletion-increases-k-replacement-needs\nProlonged experimental Mg depletion caused hypokalemia requiring substantial extra potassium intake to maintain serum K, alongside decreased exchangeable potassium.\nCondition category: nutrient_deficiency\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Supplying potassium became less effective at maintaining potassium status as Mg depletion progressed.\norganism: Homo sapiens\ntissue_or_cell_type: Blood and whole-body potassium pool\nexperimental_model: Within-person dietary depletion and repletion\nlimitations: Two elderly men; no native human channel assay and no causal localization of potassium loss to ROMK.\ncross_nutrient: magnesium -> potassium\n[shils-1964-human-depletion] Experimental Human Magnesium Depletion. I. Clinical Observations and Blood Chemistry Alterations (1964). https://pubmed.ncbi.nlm.nih.gov/14212747/ DOI: 10.1093/ajcn/15.3.133","model_system":"Within-person dietary depletion and repletion","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [shils-1964-human-depletion] Experimental Human Magnesium Depletion. I. Clinical Observations and Blood Chemistry Alterations (1964). https://pubmed.ncbi.nlm.nih.gov/14212747/ DOI: 10.1093/ajcn/15.3.133","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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