Component

Plasma lactate concentration

Independent biological entity. Read linked claims for experimental scope and context.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Median lactate normalized across overall treatment groups, but not in the low-magnesium subgroup receiving the thiamine-containing preparation alone.

    Magnesium sulfate → Plasma lactate concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    Magnesium status -> response during thiamine-containing treatment.
    experimental_model
    Low-Mg thiamine-only subgroup n=22; two-hour measurement.
    exposure
    Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations.
    limitations
    Subgroup finding; no direct PDH flux or universal magnesium gate demonstrated. Pabrinex is multivitamins.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Homo sapiens
    plain_language
    Low magnesium identified a subgroup whose lactate did not normalize with the vitamin infusion alone.
    primary_references
    [b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x
    tissue_or_cell_type
    Plasma
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1611–1622

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Low-Mg thiamine-only subgroup n=22; two-hour measurement. · source_derived_draft · unverified_draft

    ### b1-aws-low-mg-lactate-response Median lactate normalized across overall treatment groups, but not in the low-magnesium subgroup receiving the thiamine-containing preparation alone. Condition category: nutrient_deficiency nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Low magnesium identified a subgroup whose lactate did not normalize with the vitamin infusion alone. organism: Homo sapiens tissue_or_cell_type: Plasma experimental_model: Low-Mg thiamine-only subgroup n=22; two-hour measurement. limitations: Subgroup finding; no direct PDH flux or universal magnesium gate demonstrated. Pabrinex is multivitamins. cross_nutrient: Magnesium status -> response during thiamine-containing treatment. exposure: Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations. [b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x
    Complete structured claim and evidence

  2. Among the 35% classified deficient at baseline, the prespecified subgroup had lower 24-hour lactate with thiamine than placebo.

    Thiamine (vitamin B1) → Plasma lactate concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    experimental_model
    Prespecified subgroup within pilot trial.
    exposure
    Intravenous thiamine 200 mg twice daily versus placebo for up to seven days or hospital discharge; trial exposure only.
    limitations
    Small subgroup; treatment did not improve overall-cohort outcomes and the exact mediator was not measured.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Homo sapiens
    plain_language
    Baseline status may help explain why some patients responded differently.
    primary_references
    [b1-donnino2016] Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study (2016). https://pubmed.ncbi.nlm.nih.gov/26771781/ DOI: 10.1097/ccm.0000000000001572
    tissue_or_cell_type
    Plasma
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1648–1658

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Prespecified subgroup within pilot trial. · source_derived_draft · unverified_draft

    ### b1-sepsis-deficient-subgroup Among the 35% classified deficient at baseline, the prespecified subgroup had lower 24-hour lactate with thiamine than placebo. Condition category: nutrient_deficiency nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Baseline status may help explain why some patients responded differently. organism: Homo sapiens tissue_or_cell_type: Plasma experimental_model: Prespecified subgroup within pilot trial. limitations: Small subgroup; treatment did not improve overall-cohort outcomes and the exact mediator was not measured. exposure: Intravenous thiamine 200 mg twice daily versus placebo for up to seven days or hospital discharge; trial exposure only. [b1-donnino2016] Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study (2016). https://pubmed.ncbi.nlm.nih.gov/26771781/ DOI: 10.1097/ccm.0000000000001572
    Complete structured claim and evidence

  3. Thiamine did not significantly lower the 24-hour lactate primary outcome in the overall septic-shock pilot cohort.

    Thiamine (vitamin B1) → Plasma lactate concentration source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    88 patients; placebo comparison.
    exposure
    Intravenous thiamine 200 mg twice daily versus placebo for up to seven days or hospital discharge; trial exposure only.
    limitations
    The study was small; overall null results do not rule out deficiency-specific effects.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Homo sapiens
    plain_language
    An essential metabolic cofactor did not improve this endpoint for the whole trial population.
    primary_references
    [b1-donnino2016] Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study (2016). https://pubmed.ncbi.nlm.nih.gov/26771781/ DOI: 10.1097/ccm.0000000000001572
    tissue_or_cell_type
    Plasma

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1636–1646

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 88 patients; placebo comparison. · source_derived_draft · unverified_draft

    ### b1-sepsis-overall-lactate-null Thiamine did not significantly lower the 24-hour lactate primary outcome in the overall septic-shock pilot cohort. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: An essential metabolic cofactor did not improve this endpoint for the whole trial population. organism: Homo sapiens tissue_or_cell_type: Plasma experimental_model: 88 patients; placebo comparison. limitations: The study was small; overall null results do not rule out deficiency-specific effects. exposure: Intravenous thiamine 200 mg twice daily versus placebo for up to seven days or hospital discharge; trial exposure only. [b1-donnino2016] Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study (2016). https://pubmed.ncbi.nlm.nih.gov/26771781/ DOI: 10.1097/ccm.0000000000001572
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards