Component

Magnesium sulfate

Clinical salt administered in the cited trial; magnesium ion remains a separate shared entity.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Median lactate normalized across overall treatment groups, but not in the low-magnesium subgroup receiving the thiamine-containing preparation alone.

    Magnesium sulfate → Plasma lactate concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    Magnesium status -> response during thiamine-containing treatment.
    experimental_model
    Low-Mg thiamine-only subgroup n=22; two-hour measurement.
    exposure
    Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations.
    limitations
    Subgroup finding; no direct PDH flux or universal magnesium gate demonstrated. Pabrinex is multivitamins.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Homo sapiens
    plain_language
    Low magnesium identified a subgroup whose lactate did not normalize with the vitamin infusion alone.
    primary_references
    [b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x
    tissue_or_cell_type
    Plasma
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1611–1622

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Low-Mg thiamine-only subgroup n=22; two-hour measurement. · source_derived_draft · unverified_draft

    ### b1-aws-low-mg-lactate-response Median lactate normalized across overall treatment groups, but not in the low-magnesium subgroup receiving the thiamine-containing preparation alone. Condition category: nutrient_deficiency nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Low magnesium identified a subgroup whose lactate did not normalize with the vitamin infusion alone. organism: Homo sapiens tissue_or_cell_type: Plasma experimental_model: Low-Mg thiamine-only subgroup n=22; two-hour measurement. limitations: Subgroup finding; no direct PDH flux or universal magnesium gate demonstrated. Pabrinex is multivitamins. cross_nutrient: Magnesium status -> response during thiamine-containing treatment. exposure: Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations. [b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x
    Complete structured claim and evidence

  2. The trial found no significant between-group effect on its primary endpoint of change in erythrocyte transketolase activity.

    Magnesium sulfate → Blood transketolase activity source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    115 analyzed; biochemical measurement two hours after treatment.
    exposure
    Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations.
    limitations
    Does not refute molecular Mg requirements or prove no effect in deficient tissues; almost all participants lacked low erythrocyte ThDP.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Homo sapiens
    plain_language
    The enzyme endpoint did not improve significantly across treatment groups.
    primary_references
    [b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x
    tissue_or_cell_type
    Erythrocytes

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1599–1609

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 115 analyzed; biochemical measurement two hours after treatment. · source_derived_draft · unverified_draft

    ### b1-aws-mg-transketolase-null The trial found no significant between-group effect on its primary endpoint of change in erythrocyte transketolase activity. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The enzyme endpoint did not improve significantly across treatment groups. organism: Homo sapiens tissue_or_cell_type: Erythrocytes experimental_model: 115 analyzed; biochemical measurement two hours after treatment. limitations: Does not refute molecular Mg requirements or prove no effect in deficient tissues; almost all participants lacked low erythrocyte ThDP. exposure: Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations. [b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x
    Complete structured claim and evidence

  3. Median time to initial GMAWS zero was 10 hours with thiamine-containing treatment, 5.5 with combined treatment and 6 with initial magnesium.

    Magnesium sulfate → Alcohol withdrawal symptom score source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Randomized treatment plus routine withdrawal care.
    exposure
    Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations.
    limitations
    The magnesium-only arm received thiamine after its two-hour sample; this is not magnesium monotherapy throughout follow-up or proof of total withdrawal cure.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Homo sapiens
    plain_language
    Initial withdrawal scores reached zero sooner in the magnesium arms.
    primary_references
    [b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x
    tissue_or_cell_type
    Clinical symptom score

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1624–1634

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized treatment plus routine withdrawal care. · source_derived_draft · unverified_draft

    ### b1-aws-resolution-time Median time to initial GMAWS zero was 10 hours with thiamine-containing treatment, 5.5 with combined treatment and 6 with initial magnesium. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Initial withdrawal scores reached zero sooner in the magnesium arms. organism: Homo sapiens tissue_or_cell_type: Clinical symptom score experimental_model: Randomized treatment plus routine withdrawal care. limitations: The magnesium-only arm received thiamine after its two-hour sample; this is not magnesium monotherapy throughout follow-up or proof of total withdrawal cure. exposure: Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations. [b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards