{"id":"07b5dda6-ca48-5931-a71f-487983118adf","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-aws-resolution-time","predicate":"is_associated_with_shorter","statement":"Median time to initial GMAWS zero was 10 hours with thiamine-containing treatment, 5.5 with combined treatment and 6 with initial magnesium.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7c97a74c-f604-5059-ab6f-00f801cf64dd","mechanism_event_label":"Initial withdrawal scores reached zero sooner in the magnesium arms.","subject":{"id":"a95e39a4-11bb-5519-a308-8a034b2addcc","slug":"magnesium-sulfate","display_name":"Magnesium sulfate","entity_type_key":"chemical_species"},"object":{"id":"175b3256-eef6-56cc-a4cc-e5a44b4f41a3","slug":"alcohol-withdrawal-symptoms","display_name":"Alcohol withdrawal symptom score","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7c97a74c-f604-5059-ab6f-00f801cf64dd","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-aws-resolution-time-event","event_type":"observed_intervention","label":"Initial withdrawal scores reached zero sooner in the magnesium arms.","description":"Median time to initial GMAWS zero was 10 hours with thiamine-containing treatment, 5.5 with combined treatment and 6 with initial magnesium.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"subsequent_or_combined_intervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a95e39a4-11bb-5519-a308-8a034b2addcc","slug":"magnesium-sulfate","display_name":"Magnesium sulfate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"175b3256-eef6-56cc-a4cc-e5a44b4f41a3","slug":"alcohol-withdrawal-symptoms","display_name":"Alcohol withdrawal symptom score","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Randomized treatment plus routine withdrawal care.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The magnesium-only arm received thiamine after its two-hour sample; this is not magnesium monotherapy throughout follow-up or proof of total withdrawal cure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Initial withdrawal scores reached zero sooner in the magnesium arms.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Clinical symptom score","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b0009fca-1a6a-5926-b782-1a05aeba5cae","evidence_kind":"source_excerpt","locator":"Lines 1624-1634","start_line":1624,"end_line":1634,"excerpt":"### b1-aws-resolution-time\nMedian time to initial GMAWS zero was 10 hours with thiamine-containing treatment, 5.5 with combined treatment and 6 with initial magnesium.\nCondition category: normal\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Initial withdrawal scores reached zero sooner in the magnesium arms.\norganism: Homo sapiens\ntissue_or_cell_type: Clinical symptom score\nexperimental_model: Randomized treatment plus routine withdrawal care.\nlimitations: The magnesium-only arm received thiamine after its two-hour sample; this is not magnesium monotherapy throughout follow-up or proof of total withdrawal cure.\nexposure: Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations.\n[b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x","model_system":"Randomized treatment plus routine withdrawal care.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}