{"id":"35fda3a9-94a8-50cf-9565-61c43499e8a7","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-aws-low-mg-lactate-response","predicate":"modifies_observed_response","statement":"Median lactate normalized across overall treatment groups, but not in the low-magnesium subgroup receiving the thiamine-containing preparation alone.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"34c25466-26bc-5c56-b8f7-632409aa8ccf","mechanism_event_label":"Low magnesium identified a subgroup whose lactate did not normalize with the vitamin infusion alone.","subject":{"id":"a95e39a4-11bb-5519-a308-8a034b2addcc","slug":"magnesium-sulfate","display_name":"Magnesium sulfate","entity_type_key":"chemical_species"},"object":{"id":"c5d7cf62-96f0-5039-9f29-cfb6d22de143","slug":"plasma-lactate-concentration","display_name":"Plasma lactate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"34c25466-26bc-5c56-b8f7-632409aa8ccf","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-aws-low-mg-lactate-response-event","event_type":"observed_intervention","label":"Low magnesium identified a subgroup whose lactate did not normalize with the vitamin infusion alone.","description":"Median lactate normalized across overall treatment groups, but not in the low-magnesium subgroup receiving the thiamine-containing preparation alone.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"nutrient_ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5ebd9a7c-b151-5b70-b70d-7d33067d4ebf","slug":"lactate","display_name":"L-Lactate","entity_type_key":"small_molecule"},"role":"measured_species","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a95e39a4-11bb-5519-a308-8a034b2addcc","slug":"magnesium-sulfate","display_name":"Magnesium sulfate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"c5d7cf62-96f0-5039-9f29-cfb6d22de143","slug":"plasma-lactate-concentration","display_name":"Plasma lactate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Magnesium status -> response during thiamine-containing treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Low-Mg thiamine-only subgroup n=22; two-hour measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Subgroup finding; no direct PDH flux or universal magnesium gate demonstrated. Pabrinex is multivitamins.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Low magnesium identified a subgroup whose lactate did not normalize with the vitamin infusion alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"ce4ec70b-01b8-5d43-9d0c-6d08affae11a","evidence_kind":"source_excerpt","locator":"Lines 1611-1622","start_line":1611,"end_line":1622,"excerpt":"### b1-aws-low-mg-lactate-response\nMedian lactate normalized across overall treatment groups, but not in the low-magnesium subgroup receiving the thiamine-containing preparation alone.\nCondition category: nutrient_deficiency\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Low magnesium identified a subgroup whose lactate did not normalize with the vitamin infusion alone.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma\nexperimental_model: Low-Mg thiamine-only subgroup n=22; two-hour measurement.\nlimitations: Subgroup finding; no direct PDH flux or universal magnesium gate demonstrated. Pabrinex is multivitamins.\ncross_nutrient: Magnesium status -> response during thiamine-containing treatment.\nexposure: Thiamine 250 mg as Pabrinex, magnesium sulfate 2 g, or both; biochemical samples at two hours. Initial magnesium-only group then received thiamine. Study regimens, not recommendations.\n[b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x","model_system":"Low-Mg thiamine-only subgroup n=22; two-hour measurement.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b1-maguire2022] Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores (2022). https://pubmed.ncbi.nlm.nih.gov/35484175/ DOI: 10.1038/s41598-022-10970-x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}