{"id":"c4195184-1ac8-55b2-b754-960100f97456","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-sepsis-overall-lactate-null","predicate":"does_not_significantly_reduce","statement":"Thiamine did not significantly lower the 24-hour lactate primary outcome in the overall septic-shock pilot cohort.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"35e539f1-e2b2-5e96-841a-ef635dfc8762","mechanism_event_label":"An essential metabolic cofactor did not improve this endpoint for the whole trial population.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"c5d7cf62-96f0-5039-9f29-cfb6d22de143","slug":"plasma-lactate-concentration","display_name":"Plasma lactate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"35e539f1-e2b2-5e96-841a-ef635dfc8762","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-sepsis-overall-lactate-null-event","event_type":"observed_intervention","label":"An essential metabolic cofactor did not improve this endpoint for the whole trial population.","description":"Thiamine did not significantly lower the 24-hour lactate primary outcome in the overall septic-shock pilot cohort.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5ebd9a7c-b151-5b70-b70d-7d33067d4ebf","slug":"lactate","display_name":"L-Lactate","entity_type_key":"small_molecule"},"role":"endpoint_species","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c5d7cf62-96f0-5039-9f29-cfb6d22de143","slug":"plasma-lactate-concentration","display_name":"Plasma lactate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"88 patients; placebo comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Intravenous thiamine 200 mg twice daily versus placebo for up to seven days or hospital discharge; trial exposure only.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The study was small; overall null results do not rule out deficiency-specific effects.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"An essential metabolic cofactor did not improve this endpoint for the whole trial population.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b1-donnino2016] Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study (2016). https://pubmed.ncbi.nlm.nih.gov/26771781/ DOI: 10.1097/ccm.0000000000001572","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9c09fa4e-940e-5dfa-ae5d-d09769ff315e","evidence_kind":"source_excerpt","locator":"Lines 1636-1646","start_line":1636,"end_line":1646,"excerpt":"### b1-sepsis-overall-lactate-null\nThiamine did not significantly lower the 24-hour lactate primary outcome in the overall septic-shock pilot cohort.\nCondition category: normal\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An essential metabolic cofactor did not improve this endpoint for the whole trial population.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma\nexperimental_model: 88 patients; placebo comparison.\nlimitations: The study was small; overall null results do not rule out deficiency-specific effects.\nexposure: Intravenous thiamine 200 mg twice daily versus placebo for up to seven days or hospital discharge; trial exposure only.\n[b1-donnino2016] Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study (2016). https://pubmed.ncbi.nlm.nih.gov/26771781/ DOI: 10.1097/ccm.0000000000001572","model_system":"88 patients; placebo comparison.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b1-donnino2016] Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study (2016). https://pubmed.ncbi.nlm.nih.gov/26771781/ DOI: 10.1097/ccm.0000000000001572","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}